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Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

Medicinal research reviews, 2019-05, Vol.39 (3), p.775-830

2019

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Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

European journal of medicinal chemistry, 2018-10, Vol.158, p.167-183

2018

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New ligands of the tubulin colchicine site based on X-ray structures

Current topics in medicinal chemistry, 2014-01, Vol.14 (20), p.2231-2252

2014

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Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1907

2021

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New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.2025-2044

2021

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Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.1029-1047

2021

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New diarylsulfonamide inhibitors of Leishmania infantum amastigotes

International journal for parasitology -- drugs and drug resistance, 2021-08, Vol.16, p.45-64

2021

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Further Naphthylcombretastatins. An Investigation on the Role of the Naphthalene Moiety

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.556-568

2005

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Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation

Bioorganic & medicinal chemistry, 2008-10, Vol.16 (19), p.8999-9008

2008

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A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues

Molecules, 2000-01, Vol.5 (1), p.51-81

2000

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Biosynthesis of podophyllotoxin in Linum album cell cultures

Planta, 2002-10, Vol.215 (6), p.1031-1039

2002

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Inhibition of the intestinal absorption of bile acids using cationic derivatives: Mechanism and repercussions

Biochemical pharmacology, 2007-02, Vol.73 (3), p.394-404

2007

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Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

European journal of medicinal chemistry, 2021-01, Vol.209, p.112933, Article 112933

2021

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Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy

Bioorganic chemistry, 2023-02, Vol.131, p.106282-106282, Article 106282

2023

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A Fast and Simple GC MS Method for Lignan Profiling in Anthriscus sylvestris and Biosynthetically Related Plant Species

Planta medica, 2001-12, Vol.67 (9), p.858-862

2001

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Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3‑Substituted Indolephenstatins and Indoleisocombretastatins

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.2813-2827

2013

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Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines

Molecules (Basel, Switzerland), 2006-11, Vol.11 (11), p.929-939

2006

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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

Bioorganic chemistry, 2020-05, Vol.98, p.103755, Article 103755

2020

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The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors

Molecules (Basel, Switzerland), 2019-11, Vol.24 (23), p.4319

2019

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Anti-HIV activity of some synthetic lignanolides and intermediates

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4483-4486

2004

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Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

European journal of medicinal chemistry, 2015-07, Vol.100, p.210-222

2015

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Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

Bioorganic & medicinal chemistry, 2009-09, Vol.17 (17), p.6422-6431

2009

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Heterolignans

Heterocycles, 1999-06, Vol.51 (6), p.1443

1999

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p,p‑Dihydroxydihydrostilbenophanes Related to Antimitotic Combretastatins. Conformational Analysis and Its Relationship to Tubulin Inhibition

Journal of organic chemistry, 2014-08, Vol.79 (15), p.6840-6857

2014

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New dicyclopentadiene-based scaffolds

Tetrahedron, 2007-03, Vol.63 (10), p.2132-2141

2007

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Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

New ligands of the tubulin colchicine site based on X-ray structures

Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy

New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling

Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

New diarylsulfonamide inhibitors of Leishmania infantum amastigotes

Further Naphthylcombretastatins. An Investigation on the Role of the Naphthalene Moiety

Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation

A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues

Biosynthesis of podophyllotoxin in Linum album cell cultures

Inhibition of the intestinal absorption of bile acids using cationic derivatives: Mechanism and repercussions

Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy

A Fast and Simple GC MS Method for Lignan Profiling in Anthriscus sylvestris and Biosynthetically Related Plant Species

Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3‑Substituted Indolephenstatins and Indoleisocombretastatins

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines

Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors

Anti-HIV activity of some synthetic lignanolides and intermediates

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

Heterolignans

p,p‑Dihydroxydihydrostilbenophanes Related to Antimitotic Combretastatins. Conformational Analysis and Its Relationship to Tubulin Inhibition

New dicyclopentadiene-based scaffolds

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