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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4417-4426

2004

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Nature (London), 2000-12, Vol.408 (6815), p.1004-1008

2000

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Discovering High-Affinity Ligands for Proteins: SAR by NMR

Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5292), p.1531-1534

1996

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Nature (London), 1999-10, Vol.401 (6755), p.818-822

1999

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NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

Nature (London), 1998-04, Vol.392 (6679), p.941-945

1998

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Discovering High-Affinity Ligands for Proteins

Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5337), p.497-499

1997

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Nature (London), 1995-12, Vol.378 (6557), p.584-592

1995

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NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

Cell, 1998-10, Vol.95 (2), p.269-277

1998

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Solution structure of a pleckstrin-homology domain

Nature (London), 1994-06, Vol.369 (6482), p.672-675

1994

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Structure of Bcl-x-Bak peptide complex: recognition between regulators of apoptosis

Science (American Association for the Advancement of Science), 1997-02, Vol.275 (5302), p.983

1997

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NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP

The Journal of biological chemistry, 2000-10, Vol.275 (43), p.33777-33781

2000

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NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Nature (London), 1996-12, Vol.384 (6610), p.638-641

1996

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Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator

Biochemistry (Easton), 1994-04, Vol.33 (16), p.4847-4864

1994

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1709-1718

2004

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Non-peptidic small molecule inhibitors of XIAP

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.771-775

2005

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NMR-Based Modification of Matrix Metalloproteinase Inhibitors with Improved Bioavailability

Journal of medicinal chemistry, 2002-12, Vol.45 (26), p.5628-5639

2002

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Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex

Biochemistry (Easton), 1993-03, Vol.32 (10), p.2473-2480

1993

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A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures

Journal of biomolecular NMR, 1998-10, Vol.12 (3), p.443

1998

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Two-dimensional NMR and structure determination of salmon calcitonin in methanol

Biochemistry (Easton), 1991-02, Vol.30 (5), p.1247-1254

1991

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On the evaluation of interproton distances for three-dimensional structure determination by NMR using a relaxation rate matrix analysis

Journal of the American Chemical Society, 1990-09, Vol.112 (19), p.6796-6803

1990

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Solution structure of the ets domain of Fli-1 when bound to DNA

Nature structural & molecular biology, 1994-12, Vol.1 (12), p.871-876

1994

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Improved NMR Structures of Protein/Ligand Complexes Using Residual Dipolar Couplings

Journal of the American Chemical Society, 1999-10, Vol.121 (39), p.9249-9250

1999

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Solution Structure of the Cytohesin-1 (B2-1) Sec7 Domain and Its Interaction with the GTPase ADP Ribosylation Factor 1

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.7909-7914

1998

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Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain

Nature structural & molecular biology, 1996-04, Vol.3 (4), p.388-393

1996

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Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7784-7788

1995

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Discovering High-Affinity Ligands for Proteins: SAR by NMR

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

Discovering High-Affinity Ligands for Proteins

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

Solution structure of a pleckstrin-homology domain

Structure of Bcl-x-Bak peptide complex: recognition between regulators of apoptosis

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator

Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Non-peptidic small molecule inhibitors of XIAP

NMR-Based Modification of Matrix Metalloproteinase Inhibitors with Improved Bioavailability

Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex

A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures

Two-dimensional NMR and structure determination of salmon calcitonin in methanol

On the evaluation of interproton distances for three-dimensional structure determination by NMR using a relaxation rate matrix analysis

Solution structure of the ets domain of Fli-1 when bound to DNA

Improved NMR Structures of Protein/Ligand Complexes Using Residual Dipolar Couplings

Solution Structure of the Cytohesin-1 (B2-1) Sec7 Domain and Its Interaction with the GTPase ADP Ribosylation Factor 1

Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain

Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor

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