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Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

Pharmacology & therapeutics (Oxford), 2017-12, Vol.180, p.62-76

2017

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Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.1856-1872

2021

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Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections

Frontiers in physiology, 2021-04, Vol.12, p.663869

2021

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Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8841

2024

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The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Journal of translational medicine, 2023-02, Vol.21 (1), p.71-71, Article 71

2023

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Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Frontiers in pharmacology, 2019-05, Vol.10, p.533-533

2019

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Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development

Molecules (Basel, Switzerland), 2021-08, Vol.26 (16), p.5034

2021

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In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Frontiers in pharmacology, 2019-05, Vol.10, p.464-464

2019

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Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers

Clinical and translational science, 2024-09, Vol.17 (9), p.e70033-n/a

2024

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sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (13), p.e2120691119-e2120691119

2022

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Determining hyperbolic 3-manifolds by their surfaces

Proceedings of the American Mathematical Society, 2019-01, Vol.147 (1), p.443-450

2019

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Development of Improved Double-Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detection in Peripheral Blood Mononuclear Cells of Diabetic Patients and the Prefrontal Cortex of Multiple Sclerosis Patients

Analytical chemistry (Washington), 2020-05, Vol.92 (10), p.7334-7342

2020

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A low-cost method for carrying loads during human walking

Journal of experimental biology, 2020-12, Vol.223 (Pt 23)

2020

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Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain

Neurotherapeutics, 2020-07, Vol.17 (3), p.900-916

2020

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Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer

Analytical methods, 2022-05, Vol.14 (18), p.181-1819

2022

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Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets

Toxicology and applied pharmacology, 2019-11, Vol.382, p.114749-114749, Article 114749

2019

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Milestones Next Steps: Results of a Feedback Questionnaire

Journal of graduate medical education, 2023-04, Vol.15 (2), p.268-271

2023

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Integral Gassman equivalence of algebraic and hyperbolic manifolds

Mathematische Zeitschrift, 2019-02, Vol.291 (1-2), p.179-194

2019

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Zariski closures and subgroup separability

Selecta mathematica (Basel, Switzerland), 2017-07, Vol.23 (3), p.2019-2027

2017

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Collisions at infinity in hyperbolic manifolds

Mathematical proceedings of the Cambridge Philosophical Society, 2013-11, Vol.155 (3), p.459-463

2013

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Absolute profinite rigidity and hyperbolic geometry

Annals of mathematics, 2020-11, Vol.192 (3), p.679-719

2020

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Isospectral Locally Symmetric Manifolds

Indiana University mathematics journal, 2014-01, Vol.63 (2), p.533-549

McReynolds, D. B.

2014

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Cusps of Hilbert modular varieties

Mathematical proceedings of the Cambridge Philosophical Society, 2008-05, Vol.144 (3), p.749-759

McREYNOLDS, D. B.

2008

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Geometric Spectra and Commensurability

Canadian journal of mathematics, 2015-02, Vol.67 (1), p.184-197

McReynolds, D. B.

2015

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Counting and effective rigidity in algebra and geometry

Inventiones mathematicae, 2018-08, Vol.213 (2), p.697-758

2018

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Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections

Preclinical Evaluation of Soluble Epoxide Hydrolase Inhibitor AMHDU against Neuropathic Pain

The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development

In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers

sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury

Determining hyperbolic 3-manifolds by their surfaces

Development of Improved Double-Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detection in Peripheral Blood Mononuclear Cells of Diabetic Patients and the Prefrontal Cortex of Multiple Sclerosis Patients

A low-cost method for carrying loads during human walking

Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain

Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer

Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets

Milestones Next Steps: Results of a Feedback Questionnaire

Integral Gassman equivalence of algebraic and hyperbolic manifolds

Zariski closures and subgroup separability

Collisions at infinity in hyperbolic manifolds

Absolute profinite rigidity and hyperbolic geometry

Isospectral Locally Symmetric Manifolds

Cusps of Hilbert modular varieties

Geometric Spectra and Commensurability

Counting and effective rigidity in algebra and geometry

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