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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (13)

2021

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The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

Current rheumatology reports, 2014-10, Vol.16 (10), p.451-451, Article 451

2014

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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.E5114-E5122

2014

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TRPV4 as a therapeutic target for joint diseases

Naunyn-Schmiedeberg's archives of pharmacology, 2015-04, Vol.388 (4), p.437-450

2015

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Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis

Scientific reports, 2016-07, Vol.6 (1), p.29053-29053, Article 29053

2016

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Relationship between T1rho Magnetic Resonance Imaging, Synovial Fluid Biomarkers, and the Biochemical and Biomechanical Properties of Cartilage

Journal of biomechanics, 2017-04, Vol.55, p.18-26

2017

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Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries

Arthritis research & therapy, 2021-11, Vol.23 (1), p.1-280, Article 280

2021

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Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

Pain (Amsterdam), 2013-08, Vol.154 (8), p.1295-1304

2013

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CXCL10 is upregulated in synovium and cartilage following articular fracture

Journal of orthopaedic research, 2018-04, Vol.36 (4), p.1220-1227

2018

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Mechanobiology of the meniscus

Journal of biomechanics, 2015-06, Vol.48 (8), p.1469-1478

2015

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Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration

Arthritis research & therapy, 2011-01, Vol.13 (6), p.R187-R187

2011

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Analytical validation and quality control/quality assurance practices for improved rigor and reproducibility of biochemical assays in orthopaedic research

Journal of orthopaedic research, 2023-07, Vol.41 (7), p.1618-1623

2023

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The Effects of Adipokines on Cartilage and Meniscus Catabolism

Connective tissue research, 2011-12, Vol.52 (6), p.523-533

2011

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A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading

Frontiers in bioengineering and biotechnology, 2022-03, Vol.10, p.837619-837619

2022

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The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis

Osteoarthritis and cartilage open, 2023-09, Vol.5 (3), p.100376, Article 100376

2023

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Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

Journal of orthopaedic research, 2013-07, Vol.31 (7), p.1039-1045

2013

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Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism

Osteoarthritis and cartilage, 2024-08, Vol.32 (8), p.938-949

2024

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Combination of Lidocaine and IL-1Ra Is Effective at Reducing Degradation of Porcine Cartilage Explants

The American journal of sports medicine, 2022-06, Vol.50 (7), p.1997-2006

2022

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Meniscus beyond mechanics: Using biology to advance our understanding of meniscus injury and treatment

Connective tissue research, 2017-05, Vol.58 (3-4), p.221-224

2017

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Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping

Journal of biomechanics, 2021-12, Vol.129, p.110771-110771, Article 110771

2021

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Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding

Journal of orthopaedic research, 2021-10, Vol.39 (10), p.2177-2186

2021

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Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias

Rare diseases (Austin, Tex.), 2014-01, Vol.2 (1), p.e962971-e962971

2014

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In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity

Journal of biomechanics, 2015-06, Vol.48 (8), p.1461-1468

2015

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Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects

Scientific reports, 2019-06, Vol.9 (1), p.8719-13, Article 8719

2019

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The Interplay of Biomechanical and Biological Changes Following Meniscus Injury

Current rheumatology reports, 2023-02, Vol.25 (2), p.35-46

2023

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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

TRPV4 as a therapeutic target for joint diseases

Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis

Relationship between T1rho Magnetic Resonance Imaging, Synovial Fluid Biomarkers, and the Biochemical and Biomechanical Properties of Cartilage

Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries

Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

CXCL10 is upregulated in synovium and cartilage following articular fracture

Mechanobiology of the meniscus

Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration

Analytical validation and quality control/quality assurance practices for improved rigor and reproducibility of biochemical assays in orthopaedic research

The Effects of Adipokines on Cartilage and Meniscus Catabolism

A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading

The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

Shedding light on the effects of blood on meniscus tissue: the role of mononuclear leukocytes in mediating meniscus catabolism

Combination of Lidocaine and IL-1Ra Is Effective at Reducing Degradation of Porcine Cartilage Explants

Meniscus beyond mechanics: Using biology to advance our understanding of meniscus injury and treatment

Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping

Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding

Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias

In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity

Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects

The Interplay of Biomechanical and Biological Changes Following Meniscus Injury

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