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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

International journal of radiation oncology, biology, physics, 2018-03, Vol.100 (4), p.1034-1043

2018

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Notch activation inhibits AML growth and survival: a potential therapeutic approach

The Journal of experimental medicine, 2013-02, Vol.210 (2), p.321-337

2013

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Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

Journal of medicinal chemistry, 2011-05, Vol.54 (10), p.3549-3563

2011

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Binding modes of peptidomimetics designed to inhibit STAT3

PloS one, 2012-12, Vol.7 (12), p.e51603

2012

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Structural Bases of Unphosphorylated STAT1 Association and Receptor Binding

Molecular cell, 2005-03, Vol.17 (6), p.761-771

2005

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The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer

PloS one, 2013-08, Vol.8 (8), p.e71508

2013

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A novel C2H2 transcription factor that regulates gliA expression interdependently with GliZ in Aspergillus fumigatus

PLoS genetics, 2014-05, Vol.10 (5), p.e1004336

2014

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Crystal structure of unphosphorylated STAT3 core fragment

Biochemical and biophysical research communications, 2008-09, Vol.374 (1), p.1-5

2008

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Long-Acting Beta Agonists Enhance Allergic Airway Disease

PloS one, 2015-11, Vol.10 (11), p.e0142212-e0142212

2015

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Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.40057-40066

2003

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Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4

Cancer, 2010-06, Vol.116 (S11), p.2806-2814

2010

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Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

ACS medicinal chemistry letters, 2014-01, Vol.5 (1), p.69-72

2014

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Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Journal of medicinal chemistry, 2005-10, Vol.48 (21), p.6661-6670

2005

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Batf is important for IL-4 expression in T follicular helper cells

Nature communications, 2015-08, Vol.6 (1), p.7997-7997, Article 7997

2015

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Pd−C-Induced Catalytic Transfer Hydrogenation with Triethylsilane

Journal of organic chemistry, 2007-08, Vol.72 (17), p.6599-6601

2007

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Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.633-636

2003

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Targeting SH2 domains in breast cancer

Future medicinal chemistry, 2014-01, Vol.6 (17), p.1909-1926

2014

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Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease

The Journal of biological chemistry, 2018-06, Vol.293 (26), p.10026-10040

2018

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STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

Nature communications, 2014-12, Vol.5 (1), p.5798-5798, Article 5798

2014

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DINC: a new AutoDock-based protocol for docking large ligands

BMC structural biology, 2013, Vol.13 Suppl 1 (S1), p.S11-S11, Article S11

2013

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Hydrodehalogenation of Alkyl Iodides with Base-Mediated Hydrogenation and Catalytic Transfer Hydrogenation: Application to the Asymmetric Synthesis of N‑Protected α‑Methylamines

Journal of organic chemistry, 2014-09, Vol.79 (17), p.8422-8427

2014

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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8970-8984

2015

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Structural basis for the binding of high affinity phosphopeptides to Stat3

Biopolymers, 2008, Vol.90 (1), p.69-79

McMurray, John S.

2008

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Pragmatic Trials

The New England journal of medicine, 2016-08, Vol.375 (5), p.454-463

2016

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Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

The New England journal of medicine, 2017-07, Vol.377 (1), p.62-70

2017

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Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

Notch activation inhibits AML growth and survival: a potential therapeutic approach

Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

Binding modes of peptidomimetics designed to inhibit STAT3

Structural Bases of Unphosphorylated STAT1 Association and Receptor Binding

The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer

A novel C2H2 transcription factor that regulates gliA expression interdependently with GliZ in Aspergillus fumigatus

Crystal structure of unphosphorylated STAT3 core fragment

Long-Acting Beta Agonists Enhance Allergic Airway Disease

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades

Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Batf is important for IL-4 expression in T follicular helper cells

Pd−C-Induced Catalytic Transfer Hydrogenation with Triethylsilane

Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3

Targeting SH2 domains in breast cancer

Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease

STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13

DINC: a new AutoDock-based protocol for docking large ligands

Hydrodehalogenation of Alkyl Iodides with Base-Mediated Hydrogenation and Catalytic Transfer Hydrogenation: Application to the Asymmetric Synthesis of N‑Protected α‑Methylamines

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

Structural basis for the binding of high affinity phosphopeptides to Stat3

Pragmatic Trials

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

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