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One Remarkable Molecule: Filaggrin

Journal of investigative dermatology, 2012-03, Vol.132 (3), p.751-762

2012

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Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Allergy (Copenhagen), 2011-07, Vol.66 (7), p.934-940

2011

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Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Journal of allergy and clinical immunology, 2015-01, Vol.135 (1), p.164-170.e4

2015

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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

Journal of allergy and clinical immunology, 2016-01, Vol.137 (1), p.130-136

2016

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Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis

Infection and immunity, 2017-06, Vol.85 (6), p.e00994-16

2017

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Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

Journal of allergy and clinical immunology, 2017-01, Vol.139 (1), p.166-172

2017

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Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Journal of allergy and clinical immunology, 2014-10, Vol.134 (4), p.818-823

2014

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Atopic Dermatitis and Disease Severity Are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants

Journal of investigative dermatology, 2014-02, Vol.134 (2), p.345-350

2014

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Keratin disorders: from gene to therapy

Human molecular genetics, 2011-10, Vol.20 (2), p.R189-R197

2011

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The persistence of atopic dermatitis and filaggrin ( FLG ) mutations in a US longitudinal cohort

Journal of allergy and clinical immunology, 2012-10, Vol.130 (4), p.912-917

2012

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Filaggrin Mutations Associated with Skin and Allergic Diseases

The New England journal of medicine, 2011-10, Vol.365 (14), p.1315-1327

2011

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A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

PLoS biology, 2013-06, Vol.11 (6), p.e1001593-e1001593

2013

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Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Journal of allergy and clinical immunology, 2014-07, Vol.134 (1), p.82-91

2014

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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

Journal of allergy and clinical immunology, 2012-04, Vol.129 (4), p.1031-1039.e1

2012

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Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

Journal of allergy and clinical immunology, 2015-11, Vol.136 (5), p.1268-1276

2015

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Filaggrin in the frontline: role in skin barrier function and disease

Journal of cell science, 2009-05, Vol.122 (9), p.1285-1294

2009

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Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

Journal of allergy and clinical immunology, 2015-04, Vol.135 (4), p.930-935.e1

2015

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Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Journal of allergy and clinical immunology, 2011-03, Vol.127 (3), p.661-667

2011

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Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

Journal of allergy and clinical immunology, 2014-10, Vol.134 (4), p.867-875.e1

2014

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CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting

Gene therapy, 2016-01, Vol.23 (1), p.108-112

2016

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Skin barrier impairment at birth predicts food allergy at 2 years of age

Journal of allergy and clinical immunology, 2016-04, Vol.137 (4), p.1111-1116.e8

2016

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Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age

British journal of dermatology (1951), 2010-12, Vol.163 (6), p.1333-1336

2010

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Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

The American journal of pathology, 2011-05, Vol.178 (5), p.2252-2263

2011

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Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

Journal of investigative dermatology, 2012-01, Vol.132 (1), p.98-104

2012

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Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome

American journal of human genetics, 2014-09, Vol.95 (3), p.308-314

2014

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One Remarkable Molecule: Filaggrin

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Atopic Dermatitis and Disease Severity Are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants

Keratin disorders: from gene to therapy

The persistence of atopic dermatitis and filaggrin ( FLG ) mutations in a US longitudinal cohort

Filaggrin Mutations Associated with Skin and Allergic Diseases

A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

Filaggrin in the frontline: role in skin barrier function and disease

Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations

CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting

Skin barrier impairment at birth predicts food allergy at 2 years of age

Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome

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