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Structure and function of the cytochrome P450 peroxygenase enzymes

Biochemical Society transactions, 2018-02, Vol.46 (1), p.183

2018

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P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

ACS catalysis, 2018-04, Vol.8 (4), p.3395-3410

2018

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Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6535-6550

2014

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Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE

The Journal of biological chemistry, 2017-03, Vol.292 (12), p.5128-5143

2017

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Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

Natural product reports, 2007-06, Vol.24 (3), p.585-609

2007

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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

International journal of molecular sciences, 2021-10, Vol.22 (21), p.11380

2021

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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (9), p.2847-2852

2015

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Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes

Biochemical Society transactions, 2012-06, Vol.40 (3), p.587

2012

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Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121

Angewandte Chemie (International ed.), 2012-09, Vol.51 (37), p.9311-9316

2012

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Characterization of Active Site Structure in CYP121: A Cytochrome P450 Essential for Viability of Mycobacterium Tuberculosis H37Rv

The Journal of biological chemistry, 2008-11, Vol.283 (48), p.33406-33416

2008

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Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets

Biochemical Society transactions, 2012-06, Vol.40 (3), p.573

2012

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Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode

The Journal of biological chemistry, 2006-12, Vol.281 (51), p.39437-39443

2006

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Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3

Biochemical journal, 2014-06, Vol.460 (2), p.247-259

2014

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Electron transfer reactions, cyanide and O2 binding of truncated hemoglobin from Bacillus subtilis

Electrochimica acta, 2013-11, Vol.110, p.86-93

2013

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P450 BM3: the very model of a modern flavocytochrome

Trends in Biochemical Sciences, 2002-05, Vol.27 (5), p.250-257

2002

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FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I

The Journal of biological chemistry, 2011-01, Vol.286 (1), p.50-59

2011

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Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

ChemistryOpen (Weinheim), 2019-07, Vol.8 (7), p.995-1011

2019

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Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment

PloS one, 2010-11, Vol.5 (11), p.e14009-e14009

2010

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Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species

PloS one, 2013-02, Vol.8 (2), p.e55708-e55708

2013

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What makes a P450 tick?

Trends in biochemical sciences (Amsterdam. Regular ed.), 2013-03, Vol.38 (3), p.140-150

2013

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Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes

Microbiology (Society for General Microbiology), 2002-10, Vol.148 (Pt 10), p.2937

2002

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Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Ã Reveals Novel Features of Cytochrome P450

The Journal of biological chemistry, 2003-02, Vol.278 (7), p.5141-5147

2003

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Drug targeting of heme proteins in Mycobacterium tuberculosis

Drug discovery today, 2017-03, Vol.22 (3), p.566-575

2017

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Redox and Spectroscopic Properties of Human Indoleamine 2,3-Dioxygenase and A His303Ala Variant: Implications for Catalysis

Biochemistry (Easton), 2005-11, Vol.44 (43), p.14318-14328

2005

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Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

ACS omega, 2017-08, Vol.2 (8), p.4705-4724

2017

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Structure and function of the cytochrome P450 peroxygenase enzymes

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes

Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121

Characterization of Active Site Structure in CYP121: A Cytochrome P450 Essential for Viability of Mycobacterium Tuberculosis H37Rv

Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets

Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode

Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3

Electron transfer reactions, cyanide and O2 binding of truncated hemoglobin from Bacillus subtilis

P450 BM3: the very model of a modern flavocytochrome

FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment

Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species

What makes a P450 tick?

Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes

Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Ã Reveals Novel Features of Cytochrome P450

Drug targeting of heme proteins in Mycobacterium tuberculosis

Redox and Spectroscopic Properties of Human Indoleamine 2,3-Dioxygenase and A His303Ala Variant: Implications for Catalysis

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

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