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Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Beilstein journal of organic chemistry, 2013-01, Vol.9 (1), p.15-25

2013

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Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages

世界胃肠病学杂志：英文版（电子版）, 2014 (48), p.18390-18396

Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla

2014

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Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways

PLoS pathogens, 2013-08, Vol.9 (8), p.e1003505-e1003505

2013

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Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent

Antimicrobial agents and chemotherapy, 2017-01, Vol.61 (1)

2017

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Current and Future Chemotherapy for Chagas Disease

Current medicinal chemistry, 2015-01, Vol.22 (37), p.4293-4312

2015

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The Trypanosoma cruzi protease cruzain mediates immune evasion

PLoS pathogens, 2011-09, Vol.7 (9), p.e1002139-e1002139

2011

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Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

PloS one, 2018-03, Vol.13 (3), p.e0193982-e0193982

2018

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Genetic analysis of basophil function in vivo

Nature immunology, 2011-06, Vol.12 (6), p.527-535

2011

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Nature medicine, 2012-06, Vol.18 (6), p.956-960

2012

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Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

PLoS neglected tropical diseases, 2020-09, Vol.14 (9), p.e0008726

2020

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Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice

PLoS pathogens, 2012-08, Vol.8 (8), p.e1002883-e1002883

2012

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The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

Antimicrobial agents and chemotherapy, 2020-04, Vol.64 (5)

2020

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Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

PLoS neglected tropical diseases, 2020-05, Vol.14 (5), p.e0007980-e0007980

2020

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Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis

PLoS neglected tropical diseases, 2015-02, Vol.9 (2), p.e0003534-e0003534

2015

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X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action

Journal of structural biology, 2016-05, Vol.194 (2), p.180-190

2016

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CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

PLoS neglected tropical diseases, 2017-12, Vol.11 (12), p.e0006104

2017

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Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole

PLoS neglected tropical diseases, 2010-04, Vol.4 (4), p.e651

2010

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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni

PLoS neglected tropical diseases, 2016-01, Vol.10 (1), p.e0004356-e0004356

2016

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Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003588

2015

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4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

PLoS neglected tropical diseases, 2017-12, Vol.11 (12), p.e0006132

2017

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Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms

PLoS neglected tropical diseases, 2018-10, Vol.12 (10), p.e0006923-e0006923

2018

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A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni

PloS one, 2009-02, Vol.4 (2), p.e4413-e4413

2009

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A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3932-3939

2007

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Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria

PLoS neglected tropical diseases, 2016-08, Vol.10 (8), p.e0004893-e0004893

2016

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IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient

Science translational medicine, 2010-12, Vol.2 (60), p.60ra88

2010

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Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways

Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent

Current and Future Chemotherapy for Chagas Disease

The Trypanosoma cruzi protease cruzain mediates immune evasion

Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

Genetic analysis of basophil function in vivo

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni

A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria

IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient

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