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Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors

PloS one, 2011-09, Vol.6 (9), p.e24949

2011

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Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery

The Journal of pharmacology and experimental therapeutics, 2009-02, Vol.328 (2), p.504

2009

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Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development

Molecular pharmacology, 2007-05, Vol.71 (5), p.1288-1297

2007

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Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities

Journal of natural products (Washington, D.C.), 2013-02, Vol.76 (2), p.243-249

2013

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Structure–activity studies with ring E analogues of methyllycaconitine on bovine adrenal α3β4 nicotinic receptors

Neuroscience research, 2002, Vol.42 (1), p.57-63

2002

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Structure–Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8681-8692

2011

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Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure–activity relationship studies

Bioorganic & medicinal chemistry, 2013-08, Vol.21 (15), p.4730-4743

2013

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3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human alpha 4 beta 2 neuronal nicotinic acetylcholine receptors

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1797-1813

2012

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3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1797-1813

2012

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Pharmacological and immunological identification of native alpha 7 nicotinic receptors: Evidence for homomeric and heteromeric alpha 7 receptors

Life sciences (1973), 2007-09, Vol.81 (16), p.1317-1322

2007

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Evidence for the involvement of adenomatous polyposis coli (APC) protein in maintaining cellular distributions of α3β4 nicotinic receptors

Neuroscience letters, 2011-02, Vol.489 (2), p.105-109

2011

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The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.3816-3824

2008

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Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening

ACS medicinal chemistry letters, 2011-11, Vol.2 (11), p.855-860

2011

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Defining the Putative Inhibitory Site for a Selective Negative Allosteric Modulator of Human α4β2 Neuronal Nicotinic Receptors

ACS chemical neuroscience, 2012-09, Vol.3 (9), p.682-692

2012

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Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4 nicotinic acetylcholine receptors through modifications to the ester

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (14), p.3739-3742

2004

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β1 - and β2 -Adrenergic Signaling in Heart Failure and Cardiac Resynchronization Therapy (CRT) with Recovery of Tissue Energetics after CRT: A Large Animal Model

Journal of cardiac failure, 2008-08, Vol.14 (6), p.S43-S43

2008

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Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors

Gene Expression Patterns, 2003-12, Vol.3 (6), p.747-754

2003

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Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native α3β4 nicotinic receptors

Neuroscience letters, 2006, Vol.392 (1), p.135-139

2006

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Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (15), p.2263-2266

1999

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Surface and intracellular nicotinic receptors expressed in intact adrenal chromaffin cells: direct measurements using [ 3H]epibatidine

Brain research, 2003-06, Vol.974 (1), p.60-69

2003

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[ 3H]Epibatidine binding to bovine adrenal medulla: evidence for α3β4 nicotinic receptors

Neuroscience letters, 2002, Vol.318 (2), p.98-102

2002

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Pharmacological characterization of recombinant bovine α3β4 neuronal nicotinic receptors stably expressed in HEK 293 cells

Neuroscience letters, 2003-06, Vol.343 (3), p.180-184

2003

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Receptor protection studies to characterize neuronal nicotinic receptors: tubocurarine prevents alkylation of adrenal nicotinic receptors

Brain research, 2001-02, Vol.891 (1), p.176-184

2001

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Characterization of [3H]Epibatidine Binding to Nicotinic Receptors from Bovine Adrenal Medulla

Annals of the New York Academy of Sciences, 2002-10, Vol.971 (1), p.162-164

2002

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Pharmacological and immunological identification of native α7 nicotinic receptors: Evidence for homomeric and heteromeric α7 receptors

Life sciences (1973), 2007-09, Vol.81 (16), p.1317-1322

2007

Volltextzugriff (PDF)

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Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors

Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery

Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development

Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities

Structure–activity studies with ring E analogues of methyllycaconitine on bovine adrenal α3β4 nicotinic receptors

Structure–Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors

Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure–activity relationship studies

3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human alpha 4 beta 2 neuronal nicotinic acetylcholine receptors

3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors

Pharmacological and immunological identification of native alpha 7 nicotinic receptors: Evidence for homomeric and heteromeric alpha 7 receptors

Evidence for the involvement of adenomatous polyposis coli (APC) protein in maintaining cellular distributions of α3β4 nicotinic receptors

The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction

Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening

Defining the Putative Inhibitory Site for a Selective Negative Allosteric Modulator of Human α4β2 Neuronal Nicotinic Receptors

Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4 nicotinic acetylcholine receptors through modifications to the ester

β1 - and β2 -Adrenergic Signaling in Heart Failure and Cardiac Resynchronization Therapy (CRT) with Recovery of Tissue Energetics after CRT: A Large Animal Model

Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors

Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native α3β4 nicotinic receptors

Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists

Surface and intracellular nicotinic receptors expressed in intact adrenal chromaffin cells: direct measurements using [ 3H]epibatidine

[ 3H]Epibatidine binding to bovine adrenal medulla: evidence for α3β4 nicotinic receptors

Pharmacological characterization of recombinant bovine α3β4 neuronal nicotinic receptors stably expressed in HEK 293 cells

Receptor protection studies to characterize neuronal nicotinic receptors: tubocurarine prevents alkylation of adrenal nicotinic receptors

Characterization of [3H]Epibatidine Binding to Nicotinic Receptors from Bovine Adrenal Medulla

Pharmacological and immunological identification of native α7 nicotinic receptors: Evidence for homomeric and heteromeric α7 receptors

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