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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.305-311

2010

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Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Journal of the American Chemical Society, 2008-04, Vol.130 (14), p.4607-4609

2008

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Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6954-6957

2006

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Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease

Angewandte Chemie (International ed.), 2008-01, Vol.47 (47), p.9104-9107

2008

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Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.322

2008

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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Journal of medicinal chemistry, 2010-03, Vol.53 (6), p.2443-2463

2010

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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2493-2496

2010

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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7207-7213

2012

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Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7201-7206

2012

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Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

ACS medicinal chemistry letters, 2011-03, Vol.2 (3), p.207-212

2011

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Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5132-5135

2009

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In Vivo Cardiac Electrophysiologic and Antiarrhythmic Effects of an Isoquinoline IKur Blocker, ISQ-1, in Rat, Dog, and Nonhuman Primate

Journal of cardiovascular pharmacology, 2007-04, Vol.49 (4), p.236-245

2007

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In vitro characterization of novel NR2B selective NMDA receptor antagonists

Neurochemistry international, 2005-05, Vol.46 (6), p.453-464

2005

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Pyridazine based inhibitors of p38 MAPK

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.689-692

2002

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Atrial Antifibrillatory Effects of Structurally Distinct I Kur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2 H )-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure

The Journal of pharmacology and experimental therapeutics, 2008-01, Vol.324 (1), p.322-330

2008

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Nonpeptide glycoprotein IIb/IIIa inhibitors. 15. Antithrombotic efficacy of L-738,167, a long-acting GPIIb/IIIa antagonist, correlates with inhibition of adenosine diphosphate-induced platelet aggregation but not with bleeding time prolongation

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.677

1997

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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2aP4 linkers

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7207-7213

2012

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Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease

Angewandte Chemie, 2008-11, Vol.120 (47), p.9244-9247

2008

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Acceptance by others and its relation to acceptance of self and others

Journal of abnormal and social psychology, 1952-07, Vol.47 (3), p.624-625

MCINTYRE, C J

1952

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Propeller Geometric Parameter Extraction From Inspection Data Clouds

Journal of ship production, 2005-11, Vol.21 (4), p.203-208

2005

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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Design and Synthesis of Novel Isoquinoline-3-nitriles as Orally Bioavailable Kv1.5 Antagonists for the Treatment of Atrial Fibrillation

Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease

Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease

Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation HepatitisC Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists

In Vivo Cardiac Electrophysiologic and Antiarrhythmic Effects of an Isoquinoline IKur Blocker, ISQ-1, in Rat, Dog, and Nonhuman Primate

In vitro characterization of novel NR2B selective NMDA receptor antagonists

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Pyridazine based inhibitors of p38 MAPK

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Atrial Antifibrillatory Effects of Structurally Distinct I Kur Blockers 3-[(Dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2 H )-one and 2-Phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in Dogs with Underlying Heart Failure

Nonpeptide glycoprotein IIb/IIIa inhibitors. 15. Antithrombotic efficacy of L-738,167, a long-acting GPIIb/IIIa antagonist, correlates with inhibition of adenosine diphosphate-induced platelet aggregation but not with bleeding time prolongation

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2aP4 linkers

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Bismacrocyclic Inhibitors of Hepatitis C NS3/4a Protease

Acceptance by others and its relation to acceptance of self and others

Propeller Geometric Parameter Extraction From Inspection Data Clouds

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