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Drosophila as an In Vivo Model for Human Neurodegenerative Disease

Genetics (Austin), 2015-10, Vol.201 (2), p.377-402

2015

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Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

Molecular cell, 2018-09, Vol.71 (5), p.703-717.e9

2018

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Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

The Journal of neuroscience, 2021-02, Vol.41 (5), p.834-844

2021

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Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Nature communications, 2020-03, Vol.11 (1), p.1580-13, Article 1580

2020

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Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

Biochemistry (Easton), 2018-12, Vol.57 (51), p.6923-6926

2018

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Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology

Scientific reports, 2022-05, Vol.12 (1), p.8140-14, Article 8140

2022

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First person – Leeanne McGurk

Journal of cell science, 2020-06, Vol.133 (12)

2020

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Editing independent effects of ADARs on the miRNA/siRNA pathways

The EMBO journal, 2009-10, Vol.28 (20), p.3145-3156

2009

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Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BMC biology, 2020-02, Vol.18 (1), p.15-15, Article 15

2020

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Three-dimensional imaging of Drosophila melanogaster

PloS one, 2007-09, Vol.2 (9), p.e834-e834

2007

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Poly(ADP-Ribosylation) in Age-Related Neurological Disease

Trends in genetics, 2019-08, Vol.35 (8), p.601-613

2019

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Nature genetics, 2014-02, Vol.46 (2), p.152-160

2014

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TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2

Journal of cell science, 2020-01

2020

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Editing independent effects of ADARs on the miRNA/siRNA pathways

The EMBO journal, 2009-10, Vol.28 (20), p.3145-3156

2009

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Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence

Human molecular genetics, 2021-09, Vol.30 (19), p.1797-1810

2021

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Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila

Human molecular genetics, 2012-01, Vol.21 (1), p.76-84

2012

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Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72

Journal of neuropathology and experimental neurology, 2014-09, Vol.73 (9), p.837-845

2014

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Yeast Informs Alzheimer's Disease

Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6060), p.1212-1213

2011

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Poly-A binding protein-1 localization to a subset of TAR DNA-binding protein of 43 kDa inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

Journal of neuropathology and experimental neurology, 2014-09, Vol.73 (9), p.837-845

2014

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Therapeutic modulation of eIF2[alpha] phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Nature genetics, 2014-02, Vol.46 (2), p.152

2014

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Cell biology. Yeast informs Alzheimer's disease

Science (American Association for the Advancement of Science), 2011-12, Vol.334 (6060), p.1212-1213

2011

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The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

Gene Expression Patterns, 2006-10, Vol.6 (8), p.900-907

2006

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The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster

BMC developmental biology, 2008-04, Vol.8 (1), p.37-37, Article 37

2008

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Ecdysteroid Action in Insect Reproduction

Encyclopedia of Hormones, 2003, Vol.1, p.451-459

2003

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Ecdysteroid Action in Insect Reproduction

Encyclopedia of Hormones, p.451-459

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Drosophila as an In Vivo Model for Human Neurodegenerative Disease

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology

First person – Leeanne McGurk

Editing independent effects of ADARs on the miRNA/siRNA pathways

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

Three-dimensional imaging of Drosophila melanogaster

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2

Editing independent effects of ADARs on the miRNA/siRNA pathways

Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence

Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila

Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion in C9orf72

Yeast Informs Alzheimer's Disease

Poly-A binding protein-1 localization to a subset of TAR DNA-binding protein of 43 kDa inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

Therapeutic modulation of eIF2[alpha] phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Cell biology. Yeast informs Alzheimer's disease

The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster

Ecdysteroid Action in Insect Reproduction

Ecdysteroid Action in Insect Reproduction

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