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Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin

Life sciences (1973), 1993, Vol.53 (14), p.1113-1120

1993

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Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models

Clinical cancer research, 1998-03, Vol.4 (3), p.743-753

1998

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Cytotoxicity and antitumor activity of carzelesin, a prodrug cyclopropylpyrroloindole analogue

Cancer research (Chicago, Ill.), 1992-09, Vol.52 (18), p.4904

1992

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Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

Journal of medicinal chemistry, 1988-03, Vol.31 (3), p.590-603

1988

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Preclinical antitumor activity of bizelesin in mice

Clinical cancer research, 1996-07, Vol.2 (7), p.1143-1149

1996

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Molecular basis for sequence-specific DNA alkylation by CC-1065

Biochemistry (Easton), 1988-05, Vol.27 (10), p.3886-3892

1988

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Lethality, DNA alkylation, and cell cycle effects of adozelesin (U-73975) on rodent and human cells

Cancer research (Chicago, Ill.), 1992-10, Vol.52 (20), p.5687-5692

1992

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Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065

Investigational new drugs, 1991-05, Vol.9 (2), p.137-148

1991

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THE CHEMISTRY, MECHANISM OF ACTION AND BIOLOGICAL PROPERTIES OF CC-1065, A POTENT ANTITUMOR ANTIBIOTIC

The Journal of Antibiotics, 1986, Vol.39(3), pp.319-334

1986

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Interspecies comparison of acivicin pharmacokinetics

Drug metabolism and disposition, 1988-01, Vol.16 (1), p.18

1988

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12,13-Isotaxanes: Synthesis of New Potent Analogs and X-ray Crystallographic Confirmation of Structure

Journal of medicinal chemistry, 1997-08, Vol.40 (18), p.2810-2812

1997

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PRELIMINARY TOXICITY STUDIES WITH THE DNA-BINDING ANTIBIOTIC, CC-1065

The Journal of Antibiotics, 1984, Vol.37(1), pp.63-70

1984

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Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogs

Journal of the American Chemical Society, 1990-06, Vol.112 (12), p.4633-4649

1990

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Relationship of Baseline Serum Bilirubin to Efficacy and Toxicity of Single-Agent Irinotecan in Patients With Metastatic Colorectal Cancer

Journal of clinical oncology, 2004-04, Vol.22 (8), p.1439-1446

2004

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Pharmacokinetics and systemic bioavailability of menogaril, and anthracycline antitumor agent, in the mouse, dog, and monkey

Cancer research (Chicago, Ill.), 1989-11, Vol.49 (22), p.6328-6336

1989

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Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection

Analytical chemistry (Washington), 1984-08, Vol.56 (9), p.1587-1590

1984

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Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate

Science (American Association for the Advancement of Science), 1981-05, Vol.212 (4497), p.933-935

1981

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Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin

The Journal of pharmacology and experimental therapeutics, 1981-03, Vol.216 (3), p.433

1981

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Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry

Analytical chemistry (Washington), 1985-09, Vol.57 (11), p.2046-2049

1985

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Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors

Cancer chemotherapy and pharmacology, 2006-08, Vol.58 (2), p.173-182

2006

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Biologically active peptides and their mass spectra

Pure and applied chemistry, 1982-01, Vol.54 (12), p.2409-2424

1982

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Activity of the anthracycline agent, 7-con-O-methylnogarol (7-OMEN), administered orally to mice bearing P388 or L1210 leukemia

Cancer treatment reports, 1980-04, Vol.64 (4-5), p.727

McGovren, J P

1980

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Bioavailability and single‐dose pharmacokinetics of intramuscular phenytoin

Clinical pharmacology and therapeutics, 1975-10, Vol.18 (4), p.449-456

1975

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Uptake and metabolism of nicotine by the isolated perfused rabbit lung

The Journal of pharmacology and experimental therapeutics, 1976-10, Vol.199 (1), p.198

1976

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Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture

Cancer research (Chicago, Ill.), 1990-09, Vol.50 (17), p.5475

1990

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Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin

Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models

Cytotoxicity and antitumor activity of carzelesin, a prodrug cyclopropylpyrroloindole analogue

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

Preclinical antitumor activity of bizelesin in mice

Molecular basis for sequence-specific DNA alkylation by CC-1065

Lethality, DNA alkylation, and cell cycle effects of adozelesin (U-73975) on rodent and human cells

Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065

THE CHEMISTRY, MECHANISM OF ACTION AND BIOLOGICAL PROPERTIES OF CC-1065, A POTENT ANTITUMOR ANTIBIOTIC

Interspecies comparison of acivicin pharmacokinetics

12,13-Isotaxanes: Synthesis of New Potent Analogs and X-ray Crystallographic Confirmation of Structure

PRELIMINARY TOXICITY STUDIES WITH THE DNA-BINDING ANTIBIOTIC, CC-1065

Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogs

Relationship of Baseline Serum Bilirubin to Efficacy and Toxicity of Single-Agent Irinotecan in Patients With Metastatic Colorectal Cancer

Pharmacokinetics and systemic bioavailability of menogaril, and anthracycline antitumor agent, in the mouse, dog, and monkey

Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection

Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate

Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin

Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry

Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors

Biologically active peptides and their mass spectra

Activity of the anthracycline agent, 7-con-O-methylnogarol (7-OMEN), administered orally to mice bearing P388 or L1210 leukemia

Bioavailability and single‐dose pharmacokinetics of intramuscular phenytoin

Uptake and metabolism of nicotine by the isolated perfused rabbit lung

Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture

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