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Utilizing a Dual Human Transporter MDCKII-MDR1-BCRP Cell Line to Assess Efflux at the Blood Brain Barrier

Drug metabolism and disposition, 2024-02, Vol.52 (2), p.95-105

2024

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The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities

Drug metabolism and disposition, 2023-07, Vol.51 (7), p.892-901

2023

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A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models

The AAPS journal, 2023-06, Vol.25 (4), p.66-66, Article 66

2023

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Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles

PloS one, 2023-05, Vol.18 (5), p.e0285798-e0285798

2023

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Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective

Clinical pharmacology and therapeutics, 2022-10, Vol.112 (4), p.770-781

2022

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Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters

Clinical pharmacology and therapeutics, 2022-09, Vol.112 (3), p.562-572

2022

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Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes

Molecular pharmaceutics, 2022-01, Vol.19 (1), p.172-187

2022

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

Cancer chemotherapy and pharmacology, 2021-09, Vol.88 (3), p.451-464

2021

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Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14530-14559

2020

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Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1137-1146

2020

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Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective

Drug discovery today, 2020-10, Vol.25 (10), p.1793-1800

2020

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Abstract 1042: Preclinical pharmacokinetic and metabolic characterization of the next generation oral SERD AZD9833

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.1042-1042

2020

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Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

Trends in pharmacological sciences (Regular ed.), 2020-06, Vol.41 (6), p.390-408

2020

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Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

Current drug metabolism, 2020-01, Vol.21 (2), p.145-162

2020

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Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Drug discovery today, 2019-05, Vol.24 (5), p.1067-1073

2019

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Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics

Molecular pharmaceutics, 2013-04, Vol.10 (4), p.1191-1206

2013

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Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption

Drug metabolism and disposition, 2011-06, Vol.39 (6), p.1008-1013

2011

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Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1259-1268

2009

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Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1126-1134

2008

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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.6013-6018

2007

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Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs

Current drug metabolism, 2007-06, Vol.8 (5), p.463-479

2007

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The pivotal role of hepatocytes in drug discovery

Chemico-biological interactions, 2007-05, Vol.168 (1), p.2-15

2007

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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (21), p.6013-6018

2007

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Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes

Drug metabolism and disposition, 2006-08, Vol.34 (8), p.1291-1300

2006

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Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes

Drug metabolism and disposition, 2005-11, Vol.33 (11), p.1700-1707

2005

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Utilizing a Dual Human Transporter MDCKII-MDR1-BCRP Cell Line to Assess Efflux at the Blood Brain Barrier

The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities

A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models

Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles

Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective

Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters

Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance

Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective

Abstract 1042: Preclinical pharmacokinetic and metabolic characterization of the next generation oral SERD AZD9833

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades

Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption

Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells

Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs

The pivotal role of hepatocytes in drug discovery

From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis

Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes

Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes

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