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Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation

Endocrine reviews, 2012-04, Vol.33 (2), p.271-299

2012

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An androgen receptor N-terminal domain antagonist for treating prostate cancer

The Journal of clinical investigation, 2013-07, Vol.123 (7), p.2948-2960

2013

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Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

Cancer cell, 2010-06, Vol.17 (6), p.535-546

2010

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Tissue control of androgen action: The ups and downs of androgen receptor expression

Molecular and cellular endocrinology, 2018-04, Vol.465, p.27-35

2018

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A sting in the tail： the N-terminal domain of the androgen receptor as a drug target

Asian journal of andrology, 2016-09, Vol.18 (5), p.687-694

2016

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Eighty Years of Targeting Androgen Receptor Activity in Prostate Cancer: The Fight Goes on

Cancers, 2021-01, Vol.13 (3), p.509

2021

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Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Cancer research (Chicago, Ill.), 2017-11, Vol.77 (22), p.6282-6298

2017

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Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations

Biochemical journal, 2005-11, Vol.391 (Pt 3), p.449-464

2005

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The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity

PloS one, 2012-03, Vol.7 (3), p.e32514-e32514

2012

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Regulation of the androgen receptor by SET9-mediated methylation

Nucleic acids research, 2011-03, Vol.39 (4), p.1266

2011

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An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

PloS one, 2015-10, Vol.10 (10), p.e0139990-e0139990

2015

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What lies beneath: natural products from marine organisms as nuclear receptor modulators

Biochemical journal, 2012-08, Vol.446 (1), p.e1-e3

McEwan, Iain J

2012

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Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure

Molecular endocrinology (Baltimore, Md.), 2010-10, Vol.24 (10), p.1935-1948

2010

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Mutation of Histidine 874 in the Androgen Receptor Ligand-Binding Domain Leads to Promiscuous Ligand Activation and Altered p160 Coactivator Interactions

Molecular endocrinology (Baltimore, Md.), 2005-12, Vol.19 (12), p.2943-2954

2005

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The Nuclear Receptor Superfamily at Thirty

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1443, p.3

McEwan, Iain J

2016

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Nuclear receptors: one big family

Methods in molecular biology (Clifton, N.J.), 2009, Vol.505, p.3

McEwan, Iain J

2009

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Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

Molecular bioSystems, 2012-01, Vol.8 (1), p.82-90

McEwan, Iain J

2012

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New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.491-511

2019

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Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer

Clinical cancer research, 2016-09, Vol.22 (17), p.4466-4477

2016

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Interactions of Abiraterone, Eplerenone, and Prednisolone with Wild-type and Mutant Androgen Receptor: A Rationale for Increasing Abiraterone Exposure or Combining with MDV3100

Cancer research (Chicago, Ill.), 2012-05, Vol.72 (9), p.2176-2182

2012

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Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

Journal of molecular endocrinology, 2008-11, Vol.41 (5), p.301-314

2008

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Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer

Clinical cancer research, 2019-11, Vol.25 (22), p.6764-6780

2019

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Intra-domain communication between the N-terminal and DNA-binding domains of the androgen receptor: modulation of androgen response element DNA binding

Journal of molecular endocrinology, 2005-06, Vol.34 (3), p.603-615

2005

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Topological dynamics of an intrinsically disordered N‐terminal domain of the human androgen receptor

Protein science, 2022-06, Vol.31 (6), p.e4334-n/a

2022

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Current and emerging approaches to noncompetitive AR inhibition

Medicinal research reviews, 2023-09, Vol.43 (5), p.1701-1747

2023

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Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation

An androgen receptor N-terminal domain antagonist for treating prostate cancer

Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

Tissue control of androgen action: The ups and downs of androgen receptor expression

A sting in the tail： the N-terminal domain of the androgen receptor as a drug target

Eighty Years of Targeting Androgen Receptor Activity in Prostate Cancer: The Fight Goes on

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations

The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity

Regulation of the androgen receptor by SET9-mediated methylation

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells

What lies beneath: natural products from marine organisms as nuclear receptor modulators

Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure

Mutation of Histidine 874 in the Androgen Receptor Ligand-Binding Domain Leads to Promiscuous Ligand Activation and Altered p160 Coactivator Interactions

The Nuclear Receptor Superfamily at Thirty

Nuclear receptors: one big family

Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer

Interactions of Abiraterone, Eplerenone, and Prednisolone with Wild-type and Mutant Androgen Receptor: A Rationale for Increasing Abiraterone Exposure or Combining with MDV3100

Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer

Intra-domain communication between the N-terminal and DNA-binding domains of the androgen receptor: modulation of androgen response element DNA binding

Topological dynamics of an intrinsically disordered N‐terminal domain of the human androgen receptor

Current and emerging approaches to noncompetitive AR inhibition

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