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Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018)

Expert opinion on therapeutic patents, 2019-04, Vol.29 (4), p.243-259

McElroy, William T.

2019

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Formal Syntheses of Naturally Occurring Welwitindolinones

Organic letters, 2012-08, Vol.14 (15), p.3834-3837

2012

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Studies toward welwitindolinones: formal syntheses of N-methylwelwitindolinone C isothiocyanate and related natural products

Tetrahedron, 2013-07, Vol.69 (27-28), p.5588-5603

2013

Volltextzugriff (PDF)

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.235-239

2012

Volltextzugriff (PDF)

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4250-4255

2016

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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1836-1841

2015

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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.677-682

2015

Volltextzugriff (PDF)

Synthesis of the CD-ring of the anticancer agent streptonigrin: studies of aryl–aryl coupling methodologies

Tetrahedron, 2006-07, Vol.62 (29), p.6945-6954

2006

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Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3203-3207

2015

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High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes

SLAS discovery, 2021-10, Vol.26 (9), p.1225-1237

2021

Volltextzugriff (PDF)

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.942-947

2015

Volltextzugriff (PDF)

Live Cell Membranome cDNA Screen: A Novel Homogenous Live Cell Binding Assay to Study Membrane Protein-Ligand Interaction

SLAS discovery, 2019-12, Vol.24 (10), p.978-986

2019

Volltextzugriff (PDF)

Siloxane-Based Cross-Coupling of Bromopyridine Derivatives: Studies for the Synthesis of Streptonigrin and Lavendamycin

Organic letters, 2003-12, Vol.5 (25), p.4779-4782

2003

Volltextzugriff (PDF)

Application of Palladium-Catalyzed Allylic Arylation to the Synthesis of a (±)-7-Deoxypancratistatin Analogue

Organic letters, 2006-09, Vol.8 (19), p.4183-4186

2006

Volltextzugriff (PDF)

Pyrazoloquinolines as PDE10A inhibitors: Discovery of a tool compound

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1335-1339

2012

Volltextzugriff (PDF)

Recent advances in siloxane-based aryl–aryl coupling reactions: focus on heteroaromatic systems

Tetrahedron, 2005-12, Vol.61 (52), p.12201-12225

2005

Volltextzugriff (PDF)

ChemInform Abstract: Pyrazoloquinolines as PDE10A Inhibitors: Discovery of a Tool Compound

ChemInform, 2012-07, Vol.43 (27), p.no-no

2012

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Mobilization of free fatty acids in dogs during respiratory acidosis

Journal of applied physiology (1948), 1961-03, Vol.16, p.339-341

1961

Volltextzugriff (PDF)

Synthesis of the CD-Ring of the Anticancer Agent Streptonigrin: Studies of Aryl-Aryl Coupling Methodologies

ChemInform, 2006-10, Vol.37 (44), p.no-no

2006

Volltextzugriff (PDF)

Effects of adrenergic blocking agents on plasma free fatty acid concentrations

The American journal of physiology, 1961-02, Vol.200 (2), p.318-322

1961

Volltextzugriff (PDF)

Some hormonal effects on uptake of free fatty acids by the liver

The American journal of physiology, 1960-11, Vol.199 (5), p.876-878

1960

Volltextzugriff (PDF)

Epinephrine-insulin antagonism on free fatty acid release

The American journal of physiology, 1961-11, Vol.201 (5), p.815-818

1961

Volltextzugriff (PDF)

Recent Advances in Siloxane-Based Aryl-Aryl Coupling Reactions: Focus on Heteroaromatic Systems

ChemInform, 2006-04, Vol.37 (16), p.no-no

2006

Volltextzugriff (PDF)

Effects of CO 2 , Bicarbonate and pH on the Performance of Isolated Perfused Guinea Pig Hearts

The American journal of physiology, 1958-10, Vol.195 (2), p.412-416

1958

Volltextzugriff (PDF)

Relationship of Hepatic Uptake of Free Fatty Acids to Plasma Concentration.

Proceedings of the Society for Experimental Biology and Medicine, 1960-05, Vol.104 (1), p.20-23

1960

Volltextzugriff (PDF)

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Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018)

Formal Syntheses of Naturally Occurring Welwitindolinones

Studies toward welwitindolinones: formal syntheses of N-methylwelwitindolinone C isothiocyanate and related natural products

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Synthesis of the CD-ring of the anticancer agent streptonigrin: studies of aryl–aryl coupling methodologies

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Live Cell Membranome cDNA Screen: A Novel Homogenous Live Cell Binding Assay to Study Membrane Protein-Ligand Interaction

Siloxane-Based Cross-Coupling of Bromopyridine Derivatives: Studies for the Synthesis of Streptonigrin and Lavendamycin

Application of Palladium-Catalyzed Allylic Arylation to the Synthesis of a (±)-7-Deoxypancratistatin Analogue

Pyrazoloquinolines as PDE10A inhibitors: Discovery of a tool compound

Recent advances in siloxane-based aryl–aryl coupling reactions: focus on heteroaromatic systems

ChemInform Abstract: Pyrazoloquinolines as PDE10A Inhibitors: Discovery of a Tool Compound

Mobilization of free fatty acids in dogs during respiratory acidosis

Synthesis of the CD-Ring of the Anticancer Agent Streptonigrin: Studies of Aryl-Aryl Coupling Methodologies

Effects of adrenergic blocking agents on plasma free fatty acid concentrations

Some hormonal effects on uptake of free fatty acids by the liver

Epinephrine-insulin antagonism on free fatty acid release

Recent Advances in Siloxane-Based Aryl-Aryl Coupling Reactions: Focus on Heteroaromatic Systems

Effects of CO 2 , Bicarbonate and pH on the Performance of Isolated Perfused Guinea Pig Hearts

Relationship of Hepatic Uptake of Free Fatty Acids to Plasma Concentration.

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