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Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Cell metabolism, 2012-08, Vol.16 (2), p.167-179

2012

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JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6173-6180

2012

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Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test: Effects of Neurokinin-1 Receptor Antagonists

Neuropsychopharmacology (New York, N.Y.), 2008-07, Vol.33 (8), p.1919-1928

2008

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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293

2004

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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3084-3092

2009

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The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Psychopharmacologia, 2002-12, Vol.165 (1), p.86-92

2002

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Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

Psychopharmacologia, 2005-04, Vol.178 (4), p.410-419

2005

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Adverse Effects of Gabapentin and Lack of Anti-Allodynic Efficacy of Amitriptyline in the Streptozotocin Model of Painful Diabetic Neuropathy

Experimental and clinical psychopharmacology, 2006-02, Vol.14 (1), p.42-51

2006

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The anxiolytic CRF1 antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

Psychopharmacologia, 2003-04, Vol.166 (4), p.408-415

2003

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Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of medicinal chemistry, 2004-11, Vol.47 (23), p.5783-5790

2004

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Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.767-770

2003

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Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4344-4361

1992

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Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats

Physiology & behavior, 1987, Vol.39 (3), p.361-365

1987

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Piperidinyltetralin .sigma. Ligands

Journal of medicinal chemistry, 1994-02, Vol.37 (3), p.364-370

1994

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Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test : Effects of Neurokinin-I Receptor Antagonists

Neuropsychopharmacology (New York, N.Y.), 2008, Vol.33 (8), p.1919-1928

2008

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Repetition, Contrariety, and Individualization in Edward II

Studies in English literature, 1500-1900, 1984-04, Vol.24 (2), p.205-224

McElroy, John F.

1984

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Effects of CRF sub(1) receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

Psychopharmacology, 2005-04, Vol.178 (4), p.410-419

2005

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The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

Psychopharmacology, 2003-04, Vol.166 (4), p.408-415

2003

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Discriminative stimulus properties of 7-OH-DPAT, a dopamine D 3-selective receptor ligand

Pharmacology, biochemistry and behavior, 1994-06, Vol.48 (2), p.531-533

McElroy, John F.

1994

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The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Psychopharmacology, 2002-12, Vol.165 (1), p.86-92

2002

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Middleton, Entertainer or Moralist? An Interpretation of the Family of Love and Your Five Gallants

Modern language quarterly (Seattle), 1976-03, Vol.37 (1), p.35-46

McElroy, John F.

1976

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Discriminative stimulus properties of 7-OH-DPAT, a dopamine D3-selective receptor ligand

Pharmacology, biochemistry and behavior, 1994-06, Vol.48 (2), p.531-533

MCELROY, J. F

1994

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Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1 H -pyrido[2,3- b ]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of medicinal chemistry, 2004-11, Vol.47 (23), p.5783-5790

2004

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Novel, highly potent, selective 5-HT 2A/D 2 receptor antagonists as potential atypical antipsychotics

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (4), p.767-770

2003

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Anxiolytic-Like Effects of the Corticotropin-Releasing Factor 1 (CRF 1 ) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5- a ]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF 1 Receptors in Rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293-302

2004

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Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities

Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test: Effects of Neurokinin-1 Receptor Antagonists

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

Adverse Effects of Gabapentin and Lack of Anti-Allodynic Efficacy of Amitriptyline in the Streptozotocin Model of Painful Diabetic Neuropathy

The anxiolytic CRF1 antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics

Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs

Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats

Piperidinyltetralin .sigma. Ligands

Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test : Effects of Neurokinin-I Receptor Antagonists

Repetition, Contrariety, and Individualization in Edward II

Effects of CRF sub(1) receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

Discriminative stimulus properties of 7-OH-DPAT, a dopamine D 3-selective receptor ligand

The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Middleton, Entertainer or Moralist? An Interpretation of the Family of Love and Your Five Gallants

Discriminative stimulus properties of 7-OH-DPAT, a dopamine D3-selective receptor ligand

Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1 H -pyrido[2,3- b ]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Novel, highly potent, selective 5-HT 2A/D 2 receptor antagonists as potential atypical antipsychotics

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor 1 (CRF 1 ) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5- a ]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF 1 Receptors in Rats

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