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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

Pharmaceutics, 2023-08, Vol.15 (8), p.2170

2023

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Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators

Bioorganic & medicinal chemistry, 2011-03, Vol.19 (5), p.1658-1665

2011

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Dual repair modulation reverses Temozolomide resistance in vitro

Molecular cancer therapeutics, 2004-02, Vol.3 (2), p.123-127

2004

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Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)

Nucleic acids research, 2006-01, Vol.34 (6), p.1884-1891

2006

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Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution

Tetrahedron letters, 2009-11, Vol.50 (44), p.6022-6024

2009

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Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

Clinical cancer research, 2006-03, Vol.12 (5), p.1577-1584

2006

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Lomeguatrib, a Potent Inhibitor of O 6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

Clinical cancer research, 2006-03, Vol.12 (5), p.1577-1584

2006

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Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase

Molecular cancer therapeutics, 2004-10, Vol.3 (10), p.1215

2004

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Intermediates in the Ing-Manske reaction

ARKIVOC, 2003-05, Vol.2003 (7), p.180-189

2003

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Effect of O6‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

International journal of cancer, 2002-08, Vol.100 (5), p.615-617

2002

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Towards more specific O[super]6-methylguanine-DNA methyltransferase (MGMT) inactivators

Bioorganic & medicinal chemistry, 2011-03, Vol.19 (5), p.1658-1665

2011

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O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

International journal of cancer, 2000-01, Vol.85 (2), p.248

2000

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Effect of O 6 ‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

International journal of cancer, 2002-08, Vol.100 (5), p.615-617

2002

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Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O 6-alkylguanine-DNA alkyltransferase

Molecular cancer therapeutics, 2004-10, Vol.3 (10), p.1215-1220

2004

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Inactivation of O 6-Alkylguanine-DNA Alkyltransferase. 1. Novel O 6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain

Journal of medicinal chemistry, 1998-12, Vol.41 (26), p.5265-5271

1998

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N,N′-Transphthaloylation in a Monoprotected Diamine

Synthesis (Stuttgart), 2006-03, Vol.2006 (6), p.983-988

2006

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O6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

International journal of cancer, 2000-01, Vol.85 (2), p.248-252

2000

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O6‐(4‐bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

International journal of cancer, 2000-01, Vol.85 (2), p.248-252

2000

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Nitrosoureas from chemist to physician: Classification and recent approaches to drug design

European journal of cancer & clinical oncology, 1990-03, Vol.26 (3), p.207-221

1990

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Inactivation of O6-Alkylguanine-DNA Alkyltransferase. 1. Novel O6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain

Journal of medicinal chemistry, 1998-12, Vol.41 (26), p.5265-5271

1998

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Nucleoside Analogs. 14. The Synthesis and Antitumor Activity in Mice of Molecular Combinations of 5-Fluorouracil and N-(2-Chloroethyl)-N-nitrosourea Moieties Separated by a Three-Carbon Chain

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1403-1412

1996

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Synthesis of Potential Anticancer Agents. V. Azetidines1,2

Journal of organic chemistry, 1961-01, Vol.26 (1), p.138-144

1961

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Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue

Anti-cancer drug design, 1996-03, Vol.11 (2), p.117

1996

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Effect of Dithiocarbanilates on Some Biological and Biophysical Properties of Leukemia L1210 Cell Membranes

Molecular pharmacology, 1978-11, Vol.14 (6), p.1121-1129

1978

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Nucleoside analogues. Part 10. Synthesis of three unusual 5-fluorouracil seco-nucleosides incorporating N-(2-chloroethyl)-N-nitrosourea residues

Journal of the Chemical Society, Perkin Transactions 1, 1990 (3), p.795

1990

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QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators

Dual repair modulation reverses Temozolomide resistance in vitro

Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)

Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution

Lomeguatrib, a Potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

Lomeguatrib, a Potent Inhibitor of O 6-Alkylguanine-DNA-Alkyltransferase: Phase I Safety, Pharmacodynamic, and Pharmacokinetic Trial and Evaluation in Combination with Temozolomide in Patients with Advanced Solid Tumors

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase

Intermediates in the Ing-Manske reaction

Effect of O6‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

Towards more specific O[super]6-methylguanine-DNA methyltransferase (MGMT) inactivators

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

Effect of O 6 ‐(4‐bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O 6-alkylguanine-DNA alkyltransferase

Inactivation of O 6-Alkylguanine-DNA Alkyltransferase. 1. Novel O 6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain

N,N′-Transphthaloylation in a Monoprotected Diamine

O6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

O6‐(4‐bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

Nitrosoureas from chemist to physician: Classification and recent approaches to drug design

Inactivation of O6-Alkylguanine-DNA Alkyltransferase. 1. Novel O6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain

Nucleoside Analogs. 14. The Synthesis and Antitumor Activity in Mice of Molecular Combinations of 5-Fluorouracil and N-(2-Chloroethyl)-N-nitrosourea Moieties Separated by a Three-Carbon Chain

Synthesis of Potential Anticancer Agents. V. Azetidines1,2

Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue

Effect of Dithiocarbanilates on Some Biological and Biophysical Properties of Leukemia L1210 Cell Membranes

Nucleoside analogues. Part 10. Synthesis of three unusual 5-fluorouracil seco-nucleosides incorporating N-(2-chloroethyl)-N-nitrosourea residues

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