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Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Nature communications, 2021-08, Vol.12 (1), p.5103-5103, Article 5103

2021

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Estrogen Receptor Signaling in the Immune System

Endocrine reviews, 2023-02, Vol.44 (1), p.117-141

2023

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Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer

Journal of medicinal chemistry, 2015-06, Vol.58 (12), p.4883-4887

2015

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27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6162), p.1094-1098

2013

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The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Nature communications, 2017-10, Vol.8 (1), p.864-11, Article 864

2017

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PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo

Cancer letters, 2022-10, Vol.545, p.215832-215832, Article 215832

2022

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Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer

Molecular oncology, 2015-06, Vol.9 (6), p.1155-1168

2015

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Cholesterol and breast cancer pathophysiology

Trends in endocrinology and metabolism, 2014-12, Vol.25 (12), p.649-655

2014

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Eosinophilia in cancer and its regulation by sex hormones

Trends in endocrinology and metabolism, 2023-01, Vol.34 (1), p.5-20

2023

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The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer

Current opinion in pharmacology, 2010-12, Vol.10 (6), p.620-628

2010

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Copper signaling axis as a target for prostate cancer therapeutics

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (20), p.5819-5831

2014

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ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Cell reports (Cambridge), 2016-04, Vol.15 (2), p.323-335

2016

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The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Bone (New York, N.Y.), 2013-03, Vol.53 (1), p.42-50

2013

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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Nature communications, 2018-04, Vol.9 (1), p.1677-13, Article 1677

2018

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The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer

Cancer cell, 2011-10, Vol.20 (4), p.500-510

2011

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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Angewandte Chemie (International ed.), 2015-08, Vol.54 (33), p.9659-9662

International ed. in English, 2015

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Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Communications biology, 2018-01, Vol.1 (1), p.100-100, Article 100

2018

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Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer

Essays in biochemistry, 2021-12, Vol.65 (6), p.985-1001

2021

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Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer

Endocrine-related cancer, 2017-07, Vol.24 (7), p.339-349

2017

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CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

Cancer research (Chicago, Ill.), 2017-04, Vol.77 (7), p.1662-1673

2017

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Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma

The Journal of clinical investigation, 2021-12, Vol.131 (23)

2021

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CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Nature communications, 2019-06, Vol.10 (1), p.2450-2450, Article 2450

2019

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Next-Generation Endocrine Therapies for Breast Cancer

Journal of clinical oncology, 2021-04, Vol.39 (12), p.1383-1388

2021

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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Cell metabolism, 2017-10, Vol.26 (4), p.648-659.e8

2017

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Bazedoxifene Exhibits Antiestrogenic Activity in Animal Models of Tamoxifen-Resistant Breast Cancer: Implications for Treatment of Advanced Disease

Clinical cancer research, 2013-05, Vol.19 (9), p.2420-2431

2013

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Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Estrogen Receptor Signaling in the Immune System

Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer

Cholesterol and breast cancer pathophysiology

Eosinophilia in cancer and its regulation by sex hormones

The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer

Copper signaling axis as a target for prostate cancer therapeutics

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer

Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer

CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Next-Generation Endocrine Therapies for Breast Cancer

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Bazedoxifene Exhibits Antiestrogenic Activity in Animal Models of Tamoxifen-Resistant Breast Cancer: Implications for Treatment of Advanced Disease

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