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Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2181-2184

2009

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Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors

Journal of the American Chemical Society, 2002-09, Vol.124 (35), p.10260-10261

2002

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Fermentative production of self-toxic fungal secondary metabolites

Journal of industrial microbiology & biotechnology, 2010-04, Vol.37 (4), p.335-340

2010

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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

Molecular cancer therapeutics, 2007-11, Vol.6 (11), p.3028-3038

2007

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Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179

Journal of organic chemistry, 2010-03, Vol.75 (5), p.1643-1651

2010

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07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

Journal of natural products (Washington, D.C.), 2004-09, Vol.67 (9), p.1565-1567

2004

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The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144

Journal of natural products (Washington, D.C.), 2009-11, Vol.72 (11), p.1944-1948

2009

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Namenamicin, a New Enediyne Antitumor Antibiotic from the Marine Ascidian Polysyncraton lithostrotum

Journal of the American Chemical Society, 1996-11, Vol.118 (44), p.10898-10899

1996

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Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

Pharmaceutical biology, 2011-03, Vol.49 (3), p.296-301

2011

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Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Journal of organic chemistry, 2009-08, Vol.74 (16), p.5902-5908

2009

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Tawicyclamides A and B, new cyclic peptides from the Ascidian Lissoclinum patella: studies on the solution- and solid-state conformations

Journal of organic chemistry, 1992-08, Vol.57 (17), p.4616-4624

1992

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FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730-2739

2003

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FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMSn, the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730-2739

2003

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Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of Their derivatives

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (17), p.2341-2344

2002

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In Support of the Original Medermycin/Lactoquinomycin A Structure

Organic letters, 2002-12, Vol.4 (26), p.4659-4662

2002

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Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids from a Cystodytes sp. Ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II

Journal of medicinal chemistry, 1994-10, Vol.37 (22), p.3819-3827

1994

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Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

Tetrahedron letters, 1999-03, Vol.40 (13), p.2489-2492

1999

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FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMS n , the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730-2739

2003

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Patellamide E: a New Cyclic Peptide from the Ascidian Lissoclinum patella

Journal of natural products (Washington, D.C.), 1992-03, Vol.55 (3), p.376-379

1992

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Biosynthesis of Ganefromycin: Results from Blocked Mutants and Bioconversion Experiments

Journal of natural products (Washington, D.C.), 1998-02, Vol.61 (2), p.217-226

1998

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Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCξ

Journal of organic chemistry, 2009, Vol.74 (16), p.5902-5908

2009

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FTMS structure elucidation of natural products: Application to muraymycin antibiotics using ESI Multi-CHEF SORI-CID FTMSn, the top-down/bottom-up approach,and HPLC ESI capillay-skimmer

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730

2003

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Natural Products: Drug Discovery and Therapeutic Medicine Edited by L. Zhang (SynerZ Pharmaceuticals Inc.) and A. L. Demain (Health and Drew University). Humana Press, Totowa, NJ. 2005. xiv + 382 pp. 71/4 × 10 in. $135.00. ISBN 1-588-29-383-1

Journal of Natural Products, 2005, Vol.68 (11), p.1713-1714

McDonald, Leonard A

2005

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Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta

Journal of organic chemistry, 2009-08, Vol.74 (16), p.5902

2009

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Natural Products: Drug Discovery and Therapeutic Medicine Edited by L. Zhang (SynerZ Pharmaceuticals Inc.) and A. L. Demain (Health and Drew University). Humana Press, Totowa, NJ. 2005. xiv + 382 pp. 7 1 / 4 × 10 in. $135.00. ISBN 1-588-29-383-1

Journal of Natural Products, 2005, Vol.68 (11), p.1713-1714

McDonald, Leonard A.

2005

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Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors

Fermentative production of self-toxic fungal secondary metabolites

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179

07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144

Namenamicin, a New Enediyne Antitumor Antibiotic from the Marine Ascidian Polysyncraton lithostrotum

Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Tawicyclamides A and B, new cyclic peptides from the Ascidian Lissoclinum patella: studies on the solution- and solid-state conformations

FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS

FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMSn, the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of Their derivatives

In Support of the Original Medermycin/Lactoquinomycin A Structure

Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids from a Cystodytes sp. Ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II

Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMS n , the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Patellamide E: a New Cyclic Peptide from the Ascidian Lissoclinum patella

Biosynthesis of Ganefromycin: Results from Blocked Mutants and Bioconversion Experiments

Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCξ

FTMS structure elucidation of natural products: Application to muraymycin antibiotics using ESI Multi-CHEF SORI-CID FTMSn, the top-down/bottom-up approach,and HPLC ESI capillay-skimmer

Natural Products: Drug Discovery and Therapeutic Medicine Edited by L. Zhang (SynerZ Pharmaceuticals Inc.) and A. L. Demain (Health and Drew University). Humana Press, Totowa, NJ. 2005. xiv + 382 pp. 71/4 × 10 in. $135.00. ISBN 1-588-29-383-1

Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta

Natural Products: Drug Discovery and Therapeutic Medicine Edited by L. Zhang (SynerZ Pharmaceuticals Inc.) and A. L. Demain (Health and Drew University). Humana Press, Totowa, NJ. 2005. xiv + 382 pp. 7 1 / 4 × 10 in. $135.00. ISBN 1-588-29-383-1

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