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Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2181-2184

2009

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Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors

Journal of the American Chemical Society, 2002-09, Vol.124 (35), p.10260-10261

2002

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Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria

Journal of the American Chemical Society, 2011-08, Vol.133 (34), p.13311-13313

2011

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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.33-38

2008

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Fermentative production of self-toxic fungal secondary metabolites

Journal of industrial microbiology & biotechnology, 2010-04, Vol.37 (4), p.335-340

2010

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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

Molecular cancer therapeutics, 2007-11, Vol.6 (11), p.3028-3038

2007

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Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179

Journal of organic chemistry, 2010-03, Vol.75 (5), p.1643-1651

2010

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The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144

Journal of natural products (Washington, D.C.), 2009-11, Vol.72 (11), p.1944-1948

2009

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Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

Pharmaceutical biology, 2011-03, Vol.49 (3), p.296-301

2011

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07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

Journal of natural products (Washington, D.C.), 2004-09, Vol.67 (9), p.1565-1567

2004

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Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Journal of organic chemistry, 2009-08, Vol.74 (16), p.5902-5908

2009

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FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730-2739

2003

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Rare 1,2'-binaphthyls Produced by Nodulisporium hinnuleum Smith (ATCC 36102)

Records of natural products, 2011-01, Vol.5 (4), p.252

2011

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Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of Their derivatives

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (17), p.2341-2344

2002

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In Support of the Original Medermycin/Lactoquinomycin A Structure

Organic letters, 2002-12, Vol.4 (26), p.4659-4662

2002

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Namenamicin, a New Enediyne Antitumor Antibiotic from the Marine Ascidian Polysyncraton lithostrotum

Journal of the American Chemical Society, 1996-11, Vol.118 (44), p.10898-10899

1996

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Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids from a Cystodytes sp. Ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II

Journal of medicinal chemistry, 1994-10, Vol.37 (22), p.3819-3827

1994

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Simulations of Si(Li) x-ray detector response

X-ray spectrometry, 2001-07, Vol.30 (4), p.230-241

2001

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FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMS n , the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Analytical chemistry (Washington), 2003-06, Vol.75 (11), p.2730-2739

2003

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Tawicyclamides A and B, new cyclic peptides from the Ascidian Lissoclinum patella: studies on the solution- and solid-state conformations

Journal of organic chemistry, 1992-08, Vol.57 (17), p.4616-4624

1992

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Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

Tetrahedron letters, 1999-03, Vol.40 (13), p.2489-2492

1999

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Patellamide E: a New Cyclic Peptide from the Ascidian Lissoclinum patella

Journal of natural products (Washington, D.C.), 1992-03, Vol.55 (3), p.376-379

1992

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Recombinant strains for the enhanced production of bioengineered rapalogs

Metabolic engineering, 2013-01, Vol.15, p.167-173

2013

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Biosynthesis of Ganefromycin: Results from Blocked Mutants and Bioconversion Experiments

Journal of natural products (Washington, D.C.), 1998-02, Vol.61 (2), p.217-226

1998

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Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

Structures of the Muraymycins, Novel Peptidoglycan Biosynthesis Inhibitors

Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Fermentative production of self-toxic fungal secondary metabolites

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179

The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144

Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery-Building chiral technology toolboxes

07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

Fibrosterol Sulfates from the Philippine Sponge Lissodendoryx (Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS

Rare 1,2'-binaphthyls Produced by Nodulisporium hinnuleum Smith (ATCC 36102)

Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of Their derivatives

In Support of the Original Medermycin/Lactoquinomycin A Structure

Namenamicin, a New Enediyne Antitumor Antibiotic from the Marine Ascidian Polysyncraton lithostrotum

Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids from a Cystodytes sp. Ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II

Simulations of Si(Li) x-ray detector response

FTMS Structure Elucidation of Natural Products: Application to Muraymycin Antibiotics Using ESI Multi-CHEF SORI-CID FTMS n , the Top-Down/Bottom-Up Approach, and HPLC ESI Capillary-Skimmer CID FTMS

Tawicyclamides A and B, new cyclic peptides from the Ascidian Lissoclinum patella: studies on the solution- and solid-state conformations

Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus

Patellamide E: a New Cyclic Peptide from the Ascidian Lissoclinum patella

Recombinant strains for the enhanced production of bioengineered rapalogs

Biosynthesis of Ganefromycin: Results from Blocked Mutants and Bioconversion Experiments

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