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Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development

Chemistry : a European journal, 2021-01, Vol.27 (5), p.1487-1513

2021

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Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity

Chemical communications (Cambridge, England), 2019-01, Vol.55 (6), p.846-849

2019

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Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3409-3414

2015

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C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway

Cellular physiology and biochemistry, 2019, Vol.53 (3), p.480-495

2019

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Heat Shock Protein Inhibitors: Success Stories

1st ed. 2016., 2016

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Predicting the unpredictable: Recent structure–activity studies on peptide-based macrocycles

Bioorganic chemistry, 2015-06, Vol.60, p.74-97

2015

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Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds

Tetrahedron, 2012-01, Vol.68 (4), p.1029-1051

2012

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Solid phase versus solution phase synthesis of heterocyclic macrocycles

Molecules (Basel, Switzerland), 2013-01, Vol.18 (1), p.1111-1121

2013

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Macrocyclic inhibitors of hsp90

Current topics in medicinal chemistry, 2010-10, Vol.10 (14), p.1380-1402

2010

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Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.728-739

2019

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Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

ACS medicinal chemistry letters, 2010-04, Vol.1 (1), p.4-8

2010

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Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d‑Amino Acids

Organic letters, 2018-02, Vol.20 (3), p.506-509

2018

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Delivering hydrophilic peptide inhibitors of heat shock protein 70 into cancer cells

Bioorganic chemistry, 2022-05, Vol.122, p.105713-105713, Article 105713

2022

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Hsp90 Mediates Membrane Deformation and Exosome Release

Molecular cell, 2018-09, Vol.71 (5), p.689-702.e9

2018

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Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.1923-1928

2013

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Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels

Polymer chemistry, 2020-01, Vol.11 (2), p.425-432

2020

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Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors

Chemistry : a European journal, 2017-02, Vol.23 (9), p.2010-2013

2017

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Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development

Chemistry : a European journal, 2021-01, Vol.27 (5), p.n/a

2021

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Halting metastasis through CXCR4 inhibition

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.20-25

2013

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A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (2), p.661-666

2014

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Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors

Chemistry : a European journal, 2016-12, Vol.22 (51), p.18572-18582

2016

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Synthesis of Second-Generation Sansalvamide A Derivatives: Novel Templates as Potential Antitumor Agents

Journal of organic chemistry, 2007-03, Vol.72 (6), p.1980-2002

2007

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Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery

Journal of medicinal chemistry, 2019-01, Vol.62 (2), p.742-761

2019

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How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?

ChemMedChem, 2017-03, Vol.12 (5), p.353-357

2017

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Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype

Chemical communications (Cambridge, England), 2019-04, Vol.55 (31), p.4515-4518

2019

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Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development

Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach

C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway

Heat Shock Protein Inhibitors: Success Stories

Predicting the unpredictable: Recent structure–activity studies on peptide-based macrocycles

Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds

Solid phase versus solution phase synthesis of heterocyclic macrocycles

Macrocyclic inhibitors of hsp90

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d‑Amino Acids

Delivering hydrophilic peptide inhibitors of heat shock protein 70 into cancer cells

Hsp90 Mediates Membrane Deformation and Exosome Release

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels

Redefining the Phenotype of Heat Shock Protein 90 (Hsp90) Inhibitors

Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development

Halting metastasis through CXCR4 inhibition

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors

Synthesis of Second-Generation Sansalvamide A Derivatives: Novel Templates as Potential Antitumor Agents

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery

How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?

Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype

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