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Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats

PloS one, 2020-07, Vol.15 (7), p.e0236363-e0236363

2020

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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

Chemical and Pharmaceutical Bulletin, 2018/03/01, Vol.66(3), pp.286-294

2018

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Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats

Journal of pharmacological sciences, 2015-03, Vol.127 (3), p.362-369

2015

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5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1- Targeted Transgenic Male Rat Model of Fragile X Syndrome

The international journal of neuropsychopharmacology, 2022-09, Vol.25 (9), p.786-793

2022

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5-H[T.sub.5A] Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome

The international journal of neuropsychopharmacology, 2022-09, Vol.25 (9), p.786

2022

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Effects of

PloS one, 2020-07, Vol.15 (7), p.e0236363

2020

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ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice

Behavioural brain research, 2020-01, Vol.378, p.112315, Article 112315

2020

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Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3

European journal of pharmacology, 2017-09, Vol.810, p.26-35

2017

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Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

Bioorganic & medicinal chemistry, 2014-07, Vol.22 (13), p.3515-3526

2014

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ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia

European neuropsychopharmacology, 2014-10, Vol.24 (10), p.1698-1708

2014

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Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors

Bioorganic & medicinal chemistry, 2019-08, Vol.27 (16), p.3692-3706

2019

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A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

European journal of pharmacology, 2012-06, Vol.685 (1-3), p.59-69

2012

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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

Chemical and Pharmaceutical Bulletin, 2018-03, Vol.66 (3), p.286-294

2018

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Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia

European neuropsychopharmacology, 2018-05, Vol.28 (5), p.620

2018

Volltextzugriff (PDF)

Functional mechanism of ASP5736, a selective serotonin 5-HT5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia

European neuropsychopharmacology, 2018-05, Vol.28 (5), p.620-629

2018

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Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans

Brain research, 2009-10, Vol.1295, p.186-191

2009

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Effects of non-steroidal anti-inflammatory drugs on Ab deposition in Ab1-42 transgenic C. elegans

Brain research, 2009-10, Vol.1295, p.186-191

2009

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Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ 1–42 transgenic C. elegans

Brain research, 2009, Vol.1295, p.186-191

2009

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Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats

Pharmacology, biochemistry and behavior, 2002-10, Vol.73 (3), p.511-519

2002

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Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans

Brain research, 2009-10, Vol.1295, p.186-191

2009

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FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action

The Journal of pharmacology and experimental therapeutics, 1996-12, Vol.279 (3), p.1157

1996

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The Possible Role of Age-Related Increase in the Plasma Glucagon/Insulin Ratio in the Enhanced Hepatic Gluconeogenesis and Hyperglycemia in Genetically Diabetic (C57BL/KsJ-db/db) Mice

Japanese Journal of Pharmacology, 1994, Vol.66 (3), p.281-288

1994

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FK960 ameliorates the memory deficits in rats through a novel mechanism of action

Japanese Journal of Pharmacology, 1997, Vol.73 (suppl.1), p.108-108

1997

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Involvement of Raphe-Hippocampal Serotonergic and Septo-Hippocampal Cholinergic Mechanisms in the Penile Erection Induced by FR121196, a Putative Cognitive Enhancer

Japanese Journal of Pharmacology, 1995, Vol.68 (1), p.85-94

1995

Volltextzugriff (PDF)

Brain somatostatin depletion by cysteamine attenuates the penile erection induced by serotonergic and dopaminergic, but not by cholinergic, activation in rats

Brain research, 1996-08, Vol.729 (1), p.132-136

1996

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Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats

Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats

5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1- Targeted Transgenic Male Rat Model of Fragile X Syndrome

5-H[T.sub.5A] Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome

Effects of

ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice

Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia

Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors

A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

Functional mechanism of ASP5736, a selective serotonin 5-HT 5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia

Functional mechanism of ASP5736, a selective serotonin 5-HT5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia

Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans

Effects of non-steroidal anti-inflammatory drugs on Ab deposition in Ab1-42 transgenic C. elegans

Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ 1–42 transgenic C. elegans

Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats

Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans

FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action

The Possible Role of Age-Related Increase in the Plasma Glucagon/Insulin Ratio in the Enhanced Hepatic Gluconeogenesis and Hyperglycemia in Genetically Diabetic (C57BL/KsJ-db/db) Mice

FK960 ameliorates the memory deficits in rats through a novel mechanism of action

Involvement of Raphe-Hippocampal Serotonergic and Septo-Hippocampal Cholinergic Mechanisms in the Penile Erection Induced by FR121196, a Putative Cognitive Enhancer

Brain somatostatin depletion by cysteamine attenuates the penile erection induced by serotonergic and dopaminergic, but not by cholinergic, activation in rats

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