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Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

Science (American Association for the Advancement of Science), 2017-06, Vol.356 (6343), p.1144-1150

2017

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The History of Flow Chemistry at Eli Lilly and Company

Chimia, 2023-05, Vol.77 (5), p.319

2023

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Flow Chemistry, Continuous Processing, and Continuous Manufacturing: A Pharmaceutical Perspective

Journal of flow chemistry, 2017-07, Vol.7 (3-4), p.137-145

May, Scott A.

2017

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The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations

Organic process research & development, 2018-09, Vol.22 (9), p.1143-1166

2018

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Perpetrator Risk Markers for Intimate Terrorism and Situational Couple Violence: A Meta-Analysis

Trauma, Violence, & Abuse, 2020-12, Vol.21 (5), p.922-931

2020

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API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing

Organic process research & development, 2021-06, Vol.25 (6), p.1284-1351

2021

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Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

Organic process research & development, 2016-11, Vol.20 (11), p.1870-1898

2016

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Development of Pd/C-Catalyzed Cyanation of Aryl Halides

Journal of organic chemistry, 2011-01, Vol.76 (2), p.665-668

2011

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Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

Organic process research & development, 2012-05, Vol.16 (5), p.1017-1038

2012

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Design and Comparison of Tubular and Pipes-in-Series Continuous Reactors for Direct Asymmetric Reductive Amination

Organic process research & development, 2016-07, Vol.20 (7), p.1305-1320

2016

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Continuous Platform To Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

Organic process research & development, 2018-08, Vol.22 (8), p.971-977

2018

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Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor

Organic process research & development, 2016-05, Vol.20 (5), p.901-910

2016

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Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

Organic letters, 2012-02, Vol.14 (4), p.1038-1041

2012

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Continuous Liquid Vapor Reactions Part 1: Design and Characterization of a Reactor for Asymmetric Hydroformylation

Organic process research & development, 2016-05, Vol.20 (5), p.888-900

2016

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Scalable Synthesis of Enantiopure Bis-3,4-diazaphospholane Ligands for Asymmetric Catalysis

Journal of organic chemistry, 2016-12, Vol.81 (23), p.11965-11970

2016

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Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle

Organic process research & development, 2016-02, Vol.20 (2), p.215-226

2016

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Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Organic process research & development, 2012-05, Vol.16 (5), p.982-1002

2012

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Development of an Alternate Synthesis for a Key JAK2 Inhibitor Intermediate via Sequential C–H Bond Functionalization

Organic process research & development, 2013-02, Vol.17 (2), p.273-281

2013

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An Efficient Synthesis of 4-Chloro-2-pyrrolino[2,3-d]pyrimidin-6-one and Its 7-Substituted Analogues

Synthesis (Stuttgart), 2012-08, Vol.44 (15), p.2396-2400

2012

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Development of a Stepwise Reductive Deoxygenation Process by Ru-Catalysed Homogeneous Ketone Reduction and Pd-Catalysed Hydrogenolysis in the Presence of Cu Salts

ChemCatChem, 2013-05, Vol.5 (5), p.1205-1210

2013

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A Selective Estrogen Receptor Modulator for the Treatment of Hot Flushes

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.843-846

2006

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Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction

Organic process research & development, 2024-05, Vol.28 (5), p.1734-1751

2024

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Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Organic process research & development, 2012-05, Vol.16 (5), p.982-1002

2012

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The Use of Nafion®-H To Promote Epoxide Cyclizations

Synthesis (Stuttgart), 1998-08, Vol.1998 (8), p.1133-1136

1998

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Synthesis of (2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-2-piperidin-4-yl-1H-imidazol-1-yl}ethyl)dimethylamine

Synthesis (Stuttgart), 2013-06, Vol.45 (11), p.1534-1540

2013

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Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

The History of Flow Chemistry at Eli Lilly and Company

Flow Chemistry, Continuous Processing, and Continuous Manufacturing: A Pharmaceutical Perspective

The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations

Perpetrator Risk Markers for Intimate Terrorism and Situational Couple Violence: A Meta-Analysis

API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing

Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

Development of Pd/C-Catalyzed Cyanation of Aryl Halides

Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

Design and Comparison of Tubular and Pipes-in-Series Continuous Reactors for Direct Asymmetric Reductive Amination

Continuous Platform To Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor

Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

Continuous Liquid Vapor Reactions Part 1: Design and Characterization of a Reactor for Asymmetric Hydroformylation

Scalable Synthesis of Enantiopure Bis-3,4-diazaphospholane Ligands for Asymmetric Catalysis

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle

Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Development of an Alternate Synthesis for a Key JAK2 Inhibitor Intermediate via Sequential C–H Bond Functionalization

An Efficient Synthesis of 4-Chloro-2-pyrrolino[2,3-d]pyrimidin-6-one and Its 7-Substituted Analogues

Development of a Stepwise Reductive Deoxygenation Process by Ru-Catalysed Homogeneous Ketone Reduction and Pd-Catalysed Hydrogenolysis in the Presence of Cu Salts

A Selective Estrogen Receptor Modulator for the Treatment of Hot Flushes

Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction

Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

The Use of Nafion®-H To Promote Epoxide Cyclizations

Synthesis of (2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-2-piperidin-4-yl-1H-imidazol-1-yl}ethyl)dimethylamine

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