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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Nature (London), 2010-08, Vol.466 (7309), p.935-940

2010

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Demystifying Functional Parameters for Irreversible Enzyme Inhibitors

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.14693-14696

2024

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Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.2

2024

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Interaction between chloride and both macro- and micronutrients in annual canarygrass

Canadian journal of plant science, 2022-06, Vol.102 (3), p.731-743

2022

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Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

ACS medicinal chemistry letters, 2022-12, Vol.13 (12), p.1856-1863

2022

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Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines

PloS one, 2015-04, Vol.10 (4), p.e0121793-e0121793

2015

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Cancer research (Chicago, Ill.), 2006-12, Vol.66 (23), p.11100-11105

2006

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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Communications chemistry, 2024-02, Vol.7 (1), p.38-38, Article 38

2024

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Discovery of Novel Insulin-Like Growth Factor‑1 Receptor Inhibitors with Unique Time-Dependent Binding Kinetics

ACS medicinal chemistry letters, 2013-07, Vol.4 (7), p.627-631

2013

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An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation

Archives of biochemistry and biophysics, 2007-08, Vol.464 (1), p.130-137

2007

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Unexpected Structural Diversity in DNA Recombination: The Restriction Endonuclease Connection

Molecular cell, 2000-06, Vol.5 (6), p.1025-1034

2000

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Fluorescence Polarization Method To Characterize Macrolide-Ribosome Interactions

Antimicrobial Agents and Chemotherapy, 2005-08, Vol.49 (8), p.3367-3372

2005

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Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors: Miniperspective

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.2-16

2024

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Abstract 1426: Sox-based sensor phosphopeptides for continuous, homogeneous and quantitative monitoring of protein phosphatase activity

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1426-1426

2023

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Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.510-515

2010

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Switching from Cut-and-Paste to Replicative Tn7 Transposition

Science (American Association for the Advancement of Science), 1996-04, Vol.272 (5260), p.401-404

1996

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Abstract 1666: A novel sox-based continuous and homogeneous assay for the discovery of inhibitors of inactive and active AKT

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1666-1666

2024

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Abstract 1676: A continuous kinetic assay to quantitate specific protein kinase activity in unfractionated cell lysates

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1676-1676

2024

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Abstract 2061: A proven activity-based workflow for the identification and characterization of time-dependent kinase inhibitors using a continuous assay format

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.2061-2061

2024

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Abstract A06: Biophysical and biochemical characterization of KRAS G12C inhibition through the SMARTTM platform

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.A06-A06

2020

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Abstract 2766: Automation of linear range determination: Enzymatic progress curve applications

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2766-2766

2023

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Abstract B37: Development of inhibitors of the activated form of KRAS G12C

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B37-B37

2020

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Response of oat grain yield and quality to nitrogen fertilizer and fungicides

Agronomy journal, 2020-03, Vol.112 (2), p.1021-1034

2020

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Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4511-4516

2013

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Abstract B43: Reversible linkage of two distinct small molecule inhibitors of MYC generates a more potent and selective dimeric inhibitor that is active in cancer cell lines over-expressing MYC

Molecular cancer research, 2015-10, Vol.13 (10_Supplement), p.B43-B43

2015

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Demystifying Functional Parameters for Irreversible Enzyme Inhibitors

Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors

Interaction between chloride and both macro- and micronutrients in annual canarygrass

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448)

Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Discovery of Novel Insulin-Like Growth Factor‑1 Receptor Inhibitors with Unique Time-Dependent Binding Kinetics

An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation

Unexpected Structural Diversity in DNA Recombination: The Restriction Endonuclease Connection

Fluorescence Polarization Method To Characterize Macrolide-Ribosome Interactions

Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors: Miniperspective

Abstract 1426: Sox-based sensor phosphopeptides for continuous, homogeneous and quantitative monitoring of protein phosphatase activity

Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR

Switching from Cut-and-Paste to Replicative Tn7 Transposition

Abstract 1666: A novel sox-based continuous and homogeneous assay for the discovery of inhibitors of inactive and active AKT

Abstract 1676: A continuous kinetic assay to quantitate specific protein kinase activity in unfractionated cell lysates

Abstract 2061: A proven activity-based workflow for the identification and characterization of time-dependent kinase inhibitors using a continuous assay format

Abstract A06: Biophysical and biochemical characterization of KRAS G12C inhibition through the SMARTTM platform

Abstract 2766: Automation of linear range determination: Enzymatic progress curve applications

Abstract B37: Development of inhibitors of the activated form of KRAS G12C

Response of oat grain yield and quality to nitrogen fertilizer and fungicides

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics

Abstract B43: Reversible linkage of two distinct small molecule inhibitors of MYC generates a more potent and selective dimeric inhibitor that is active in cancer cell lines over-expressing MYC

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