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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

International journal of molecular sciences, 2019-12, Vol.21 (1), p.141

2019

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Assessment of KRASG12C inhibitors for colorectal cancer

Frontiers in oncology, 2024-06, Vol.14, p.1412435

2024

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Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription

Anti-cancer agents in medicinal chemistry, 2024-09, Vol.24

2024

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Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine

Cancer chemotherapy and pharmacology, 2014-08, Vol.74 (2), p.291-302

2014

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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Journal of experimental & clinical cancer research, 2019-08, Vol.38 (1), p.312-312, Article 312

2019

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Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Cancers, 2020-07, Vol.12 (8), p.2022

2020

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Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

MedComm (2020), 2020-09, Vol.1 (2), p.121-128

2020

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Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

Cancers, 2023-01, Vol.15 (3), p.646

2023

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Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition

Cancer prevention research (Philadelphia, Pa.), 2010-10, Vol.3 (10), p.1303-1313

2010

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A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity

Cancer prevention research (Philadelphia, Pa.), 2009-06, Vol.2 (6), p.572-580

2009

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Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma

Cancer chemotherapy and pharmacology, 2007-02, Vol.59 (2), p.183-195

2007

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Establishment of a mammary carcinoma cell line from Syrian hamsters treated with N-methyl-N-nitrosourea

Cancer letters, 2011-12, Vol.312 (1), p.82-90

2011

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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Drug discovery today, 2020-08, Vol.25 (8), p.1521-1527

2020

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Efficacy assessment of a novel pan-RAS inhibitor in KRAS-mutant and wild type colorectal 3D bioprinted organoid tumor tissue

Journal of clinical oncology, 2024-08, Vol.42 (23_suppl), p.91-91

2024

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Assessment of KRAS G12C inhibitors for colorectal cancer

Frontiers in oncology, 2024, Vol.14, p.1412435

2024

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A potent and selective pan-RAS inhibitor, ADT-1004, targeting complex KRAS mutations for pancreatic cancer

Journal of clinical oncology, 2024-08, Vol.42 (23_suppl), p.90-90

2024

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Combinatorial treatment with carboxyamidotriazole- orotate and temozolomide in sc-implanted human LOX IMVI melanoma xenografts

Journal of solid tumors, 2012-10, Vol.2 (5), p.13-13

2012

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From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4462-4477

2021

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Identification of dithiolethiones with better chemopreventive properties than oltipraz

Carcinogenesis (New York), 1998-09, Vol.19 (9), p.1609-1615

1998

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Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2707-2707

2019

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Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2731-2731

2019

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Abstract 345: Novel RAS inhibitor, MCI-062, potently and selectively inhibits the growth of KRAS mutant pancreatic tumor cells by blocking GTP loading of RAS

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.345-345

2019

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A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice

Cancer chemotherapy and pharmacology, 2003-06, Vol.51 (6), p.488-492

2003

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Combinatorial treatment using CTO with paclitaxel or paclitaxel orotate in sc-implanted human OVCAR-5 ovarian tumor model

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.e15515-e15515

2012

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Combinatorial treatment with CTO and temozolomide in sc-implanted human LOX 1MVI melanoma

Journal of clinical oncology, 2012-05, Vol.30 (15_suppl), p.e19006-e19006

2012

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Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

Assessment of KRASG12C inhibitors for colorectal cancer

Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription

Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity

Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma

Establishment of a mammary carcinoma cell line from Syrian hamsters treated with N-methyl-N-nitrosourea

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Efficacy assessment of a novel pan-RAS inhibitor in KRAS-mutant and wild type colorectal 3D bioprinted organoid tumor tissue

Assessment of KRAS G12C inhibitors for colorectal cancer

A potent and selective pan-RAS inhibitor, ADT-1004, targeting complex KRAS mutations for pancreatic cancer

Combinatorial treatment with carboxyamidotriazole- orotate and temozolomide in sc-implanted human LOX IMVI melanoma xenografts

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Identification of dithiolethiones with better chemopreventive properties than oltipraz

Abstract 2707: A novel RAS inhibitor, MCI-062, inhibits colon tumor growth in vivo and activates antitumor immunity

Abstract 2731: A novel PDE10/beta-catenin inhibitor, MCI-048, suppresses lung tumorigenesis to block metastasis

Abstract 345: Novel RAS inhibitor, MCI-062, potently and selectively inhibits the growth of KRAS mutant pancreatic tumor cells by blocking GTP loading of RAS

A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice

Combinatorial treatment using CTO with paclitaxel or paclitaxel orotate in sc-implanted human OVCAR-5 ovarian tumor model

Combinatorial treatment with CTO and temozolomide in sc-implanted human LOX 1MVI melanoma

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