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In vitro and in vivo SAR of pyrido[3,4- d]pyramid-4-ylamine based mGluR1 antagonists

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2190-2194

2009

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Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.650-654

2015

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SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4471-4475

2009

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SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4471

2009

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived α₂δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3767-3770

2011

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Part 3: Design and synthesis of proline-derived α₂δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3771-3773

2011

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Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4409-4424

2006

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A Novel Series of Potent and Selective PDE5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3581-3594

2006

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Part 1: N-Alkylated glycines as potent α₂δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3764-3766

2011

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Design, synthesis and biological activity of β-carboline-based type-5 phosphodiesterase inhibitors

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (8), p.1425-1428

2003

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Scope of the chromium(II)-mediated synthesis of E-alkenylstannanes from aldehydes and Bu3SnCHBr2

Tetrahedron, 1995-03, Vol.51 (12), p.3713-3724

1995

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Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1284-1287

2008

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2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1702-1706

2009

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Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1284-1287

2008

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Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.486-490

2007

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Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4- d]pyrimidin-4-ylamines

Tetrahedron letters, 2007-06, Vol.48 (24), p.4293-4296

2007

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Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.905-910

2006

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The Discovery of Small Molecule Inhibitors of Neutral Endopeptidase. Structure-Activity Studies on Functionalized Glutaramides

Chemical biology & drug design, 2006-01, Vol.67 (1), p.74-77

2006

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Part 3: Design and synthesis of proline-derived α 2δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3771-3773

2011

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Chemoselectivity in the chromium(II)-mediated synthesis of E-alkenylstannanes from aldehydes and Bu3SnCHBr2

Tetrahedron letters, 1994-04, Vol.35 (14), p.2231-2234

1994

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived α 2δ ligands

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3767-3770

2011

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived alpha sub(2[delta] ligands)

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3767-3770

2011

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Part 3: Design and synthesis of proline-derived alpha sub(2[delta] ligands)

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3771-3773

2011

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Part 1: N-Alkylated glycines as potent alpha sub(2[delta] ligands)

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3764-3766

2011

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Discovery and Optimization of Selective Na v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.650-654

2015

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In vitro and in vivo SAR of pyrido[3,4- d]pyramid-4-ylamine based mGluR1 antagonists

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

Part 2: Design, synthesis and evaluation of hydroxyproline-derived α₂δ ligands

Part 3: Design and synthesis of proline-derived α₂δ ligands

Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides

A Novel Series of Potent and Selective PDE5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability

Part 1: N-Alkylated glycines as potent α₂δ ligands

Design, synthesis and biological activity of β-carboline-based type-5 phosphodiesterase inhibitors

Scope of the chromium(II)-mediated synthesis of E-alkenylstannanes from aldehydes and Bu3SnCHBr2

Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease

2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology

Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease

Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain

Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4- d]pyrimidin-4-ylamines

Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1

The Discovery of Small Molecule Inhibitors of Neutral Endopeptidase. Structure-Activity Studies on Functionalized Glutaramides

Part 3: Design and synthesis of proline-derived α 2δ ligands

Chemoselectivity in the chromium(II)-mediated synthesis of E-alkenylstannanes from aldehydes and Bu3SnCHBr2

Part 2: Design, synthesis and evaluation of hydroxyproline-derived α 2δ ligands

Part 2: Design, synthesis and evaluation of hydroxyproline-derived alpha sub(2[delta] ligands)

Part 3: Design and synthesis of proline-derived alpha sub(2[delta] ligands)

Part 1: N-Alkylated glycines as potent alpha sub(2[delta] ligands)

Discovery and Optimization of Selective Na v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

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