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Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

Cancer research (Chicago, Ill.), 2017-03, Vol.77 (5), p.1108-1118

2017

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Antitumor efficacy of combined CTLA4/PD-1 blockade without intestinal inflammation is achieved by elimination of FcγR interactions

Journal for immunotherapy of cancer, 2020-10, Vol.8 (2), p.e001584

2020

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Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy

Infection and Immunity, 2002-11, Vol.70 (11), p.6284-6293

2002

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A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

The Journal of immunology (1950), 1999-02, Vol.162 (3), p.1723-1729

1999

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IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

Cancer cell, 2011-12, Vol.20 (6), p.781-796

2011

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

The Journal of experimental medicine, 1999-10, Vol.190 (7), p.995-1004

1999

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The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice

The Journal of pharmacology and experimental therapeutics, 2016-03, Vol.356 (3), p.574-586

2016

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Abstract 4521: Evaluation of the relationship between serum exposure, receptor (GITR) availability and tumor suppression following administration of the anti-GITR antibody DX400 in mouse syngeneic tumor models

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4521-4521

2015

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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

The Journal of experimental medicine, 1996-06, Vol.183 (6), p.2669-2674

1996

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CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro

European journal of immunology, 1998-11, Vol.28 (11), p.3435-3447

1998

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

International immunology, 1993-11, Vol.5 (11), p.1461-1471

1993

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Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

Immunity (Cambridge, Mass.), 1997-05, Vol.6 (5), p.551-557

1997

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Experimental Leishmania major infection in mice: role of IL‐10

Parasite immunology, 1999-04, Vol.21 (4), p.211-218

1999

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A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE

The Journal of immunology (1950), 1992-06, Vol.148 (12), p.3783-3788

1992

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Leishmania major infection in interleukin‐4 and interferon‐γ depleted mice

Parasite immunology, 1999-08, Vol.21 (8), p.423-431

1999

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CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro

European journal of immunology, 1998-11, Vol.28 (11), p.3435-3447

1998

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CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activitiesin vitro

European journal of immunology, 1998-11, Vol.28 (11), p.3435-3447

1998

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Immunity (Cambridge, Mass.), 1994-10, Vol.1 (7), p.553-562

1994

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RB hi CD4 + T cells

Immunity (Cambridge, Mass.), 1994, Vol.1 (7), p.553-562

1994

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Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy

Antitumor efficacy of combined CTLA4/PD-1 blockade without intestinal inflammation is achieved by elimination of FcγR interactions

Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy

Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

The Role of Anti-Drug Antibodies in the Pharmacokinetics, Disposition, Target Engagement, and Efficacy of a GITR Agonist Monoclonal Antibody in Mice

Abstract 4521: Evaluation of the relationship between serum exposure, receptor (GITR) availability and tumor suppression following administration of the anti-GITR antibody DX400 in mouse syngeneic tumor models

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

Experimental Leishmania major infection in mice: role of IL‐10

A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE

Leishmania major infection in interleukin‐4 and interferon‐γ depleted mice

CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro

CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activitiesin vitro

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RB hi CD4 + T cells

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