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Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore Models

Journal of medicinal chemistry, 2002-03, Vol.45 (7), p.1402-1411

2002

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Structure-Based Design of Cyclooxygenase-2 Selectivity into Ketoprofen

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.533-537

2002

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Differential binding mode of diverse cyclooxygenase inhibitors

Journal of molecular graphics & modelling, 2002-03, Vol.20 (5), p.359-371

2002

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Rational modification of human synovial fluid phospholipase A2 inhibitors

Journal of medicinal chemistry, 1994-02, Vol.37 (3), p.337-341

1994

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Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs

Journal of clinical pharmacology, 1996-06, Vol.36 (6), p.505-512

1996

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Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase

Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (19), p.2779-2784

1999

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PHOTOCHEMICAL AND PHOTOBIOLOGICAL PROPERTIES OF KETOPROFEN ASSOCIATED WITH THE BENZOPHENONE CHROMOPHORE

Photochemistry and photobiology, 1994-08, Vol.60 (2), p.96-101

1994

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Comparison of the Efficacy and Tolerability of Dexketoprofen and Ketoprofen in the Treatment of Primary Dysmenorrhea

Journal of clinical pharmacology, 1998-12, Vol.38 (S1), p.65S-73S

1998

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Synthetic applications of 2-cyano-1,2,3,6-tetrahydropyridines. Improved synthesis of the fundamental tetracyclic framework of dasycarpidone

Journal of organic chemistry, 1982-06, Vol.47 (12), p.2435-2440

1982

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Mercuric acetate cyclization of 4-(pyrrolylmethyl)- and 4-(indolylmethyl)piperidines to bridged polycyclic systems

Journal of organic chemistry, 1983-12, Vol.48 (25), p.4836-4841

1983

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Preclinical and clinical development of dexketoprofen

Drugs (New York, N.Y.), 1996, Vol.52 Suppl 5 (Supplement 5), p.24-46

1996

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Mechanisms involved in the attenuation of intestinal toxicity induced by S(+)ketoprofen in refed rat

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A1283-A1283

2000

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Resolution of rac-ketoprofen esters by enzymatic reactions in organic media

Chirality (New York, N.Y.), 1993, Vol.5 (5), p.320-328

1993

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Evaluation of ketoprofen (R, S and [formula omitted]) phototoxicity by a battery of in vitro assays

Journal of photochemistry and photobiology. B, Biology, 1995-12, Vol.31 (3), p.133-138

1995

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Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues

Journal of medicinal chemistry, 2000-06, Vol.43 (11), p.2280-2284

2000

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Synthesis of Alkyl Chain-Modified Ether Lipids and Evaluation of Their in Vitro Cytotoxicity

Journal of medicinal chemistry, 1995-03, Vol.38 (7), p.1216-1228

1995

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Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen

Chirality (New York, N.Y.), 1993, Vol.5 (8), p.589-595

1993

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Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain

Journal of clinical pharmacology, 1998-12, Vol.38 (S1), p.46S

1998

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Analgesic, Antiinflammatory, and Antipyretic Effects of S(+)‐Ketoprofen In Vivo

Journal of clinical pharmacology, 1998-12, Vol.38 (S1), p.3S-10S

1998

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Pharmacokinetics of ketoprofen enantiomers in monkeys following single and multiple oral administration

Chirality (New York, N.Y.), 1994, Vol.6 (7), p.537-542

1994

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Synthesis and .beta.-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols

Journal of medicinal chemistry, 1988-11, Vol.31 (11), p.2122-2126

1988

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Derivation of Pharmacophore and CoMFA Models for Leukotriene D 4 Receptor Antagonists of the Quinolinyl(bridged)aryl Series

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.392-400

2000

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Stereoselective metabolic pathways of ketoprofen in the rat: Incorporation into triacylglycerols and enantiomeric inversion

Chirality (New York, N.Y.), 1996, Vol.8 (2), p.163-172

1996

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Clinical Comparison of Dexketoprofen Trometamol and Dipyrone in Postoperative Dental Pain

Journal of clinical pharmacology, 1998-12, Vol.38 (S1), p.55S-64S

1998

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4-Alkoxybenzonitriles from O-alkyl-4-nitrobenzaldoximes: an elimination-aromatic substitution reaction

Journal of organic chemistry, 1983-09, Vol.48 (18), p.3105-3106

1983

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Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore Models

Structure-Based Design of Cyclooxygenase-2 Selectivity into Ketoprofen

Differential binding mode of diverse cyclooxygenase inhibitors

Rational modification of human synovial fluid phospholipase A2 inhibitors

Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs

Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase

PHOTOCHEMICAL AND PHOTOBIOLOGICAL PROPERTIES OF KETOPROFEN ASSOCIATED WITH THE BENZOPHENONE CHROMOPHORE

Comparison of the Efficacy and Tolerability of Dexketoprofen and Ketoprofen in the Treatment of Primary Dysmenorrhea

Synthetic applications of 2-cyano-1,2,3,6-tetrahydropyridines. Improved synthesis of the fundamental tetracyclic framework of dasycarpidone

Mercuric acetate cyclization of 4-(pyrrolylmethyl)- and 4-(indolylmethyl)piperidines to bridged polycyclic systems

Preclinical and clinical development of dexketoprofen

Mechanisms involved in the attenuation of intestinal toxicity induced by S(+)ketoprofen in refed rat

Resolution of rac-ketoprofen esters by enzymatic reactions in organic media

Evaluation of ketoprofen (R, S and [formula omitted]) phototoxicity by a battery of in vitro assays

Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues

Synthesis of Alkyl Chain-Modified Ether Lipids and Evaluation of Their in Vitro Cytotoxicity

Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen

Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain

Analgesic, Antiinflammatory, and Antipyretic Effects of S(+)‐Ketoprofen In Vivo

Pharmacokinetics of ketoprofen enantiomers in monkeys following single and multiple oral administration

Synthesis and .beta.-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols

Derivation of Pharmacophore and CoMFA Models for Leukotriene D 4 Receptor Antagonists of the Quinolinyl(bridged)aryl Series

Stereoselective metabolic pathways of ketoprofen in the rat: Incorporation into triacylglycerols and enantiomeric inversion

Clinical Comparison of Dexketoprofen Trometamol and Dipyrone in Postoperative Dental Pain

4-Alkoxybenzonitriles from O-alkyl-4-nitrobenzaldoximes: an elimination-aromatic substitution reaction

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