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Navigating the orphan medicinal product designation: Evidence requirements for gene therapies in Europe

Molecular therapy, 2024-10

2024

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Multiple sclerosis, 1999-04, Vol.5 (2), p.101-104

1999

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Biomarkers for Alzheimer's disease therapeutic trials

Progress in neurobiology, 2011-12, Vol.95 (4), p.579

2011

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Monocyte‐derived cytokines in multiple sclerosis

Clinical and experimental immunology, 2003-02, Vol.131 (2), p.324-334

2003

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Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers

Journal of Proteomics, 2010, Vol.73 (6), p.1117-1132

2010

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IL‐15 mRNA expression is up‐regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS)

Clinical and experimental immunology, 1998-01, Vol.111 (1), p.193-197

1998

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Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis

Journal of neuroimmunology, 1996, Vol.64 (1), p.63-69

1996

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Effect of peppermint and thyme essential oil mist on performance and physiological parameters in broiler chickens

South African Journal of Animal Science, 2019-01, Vol.49 (1), p.29-39

2019

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Interleukin‐12 and Perforin mRNA Expression is Augmented in Blood Mononuclear Cells in Multiple Sclerosis

Scandinavian journal of immunology, 1998-06, Vol.47 (6), p.582-590

1998

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Multiple sclerosis: the proinflammatory cytokines lymphotoxin-α and tumour necrosis factor-α are upregulated in cerebrospinal fluid mononuclear cells

Journal of neuroimmunology, 1996-05, Vol.66 (1), p.115-123

1996

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Optic neuritis and cytokines: no relation to MRI abnormalities and oligoclonal bands

Neurology, 1998-01, Vol.50 (1), p.217-223

1998

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Multiple sclerosis, 1999-02, Vol.5 (2), p.101-104

1999

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Influence of IFN-β1b (Betaferon) on cytokine mRNA profiles in blood mononuclear cells and plasma levels of soluble VCAM-1 in multiple sclerosis

European journal of neurology, 1998-05, Vol.5 (3), p.265-275

1998

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High numbers of perforin mRNA expressing CSF cells in multiple sclerosis patients with gadolinium-enhancing brain MRI lesions

Acta neurologica Scandinavica, 1999-07, Vol.100 (1), p.18-24

1999

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Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA

Stroke (1970), 1998-02, Vol.29 (2), p.462-466

1998

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Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis

Acta neurologica Scandinavica, 1998-08, Vol.98 (2), p.94-101

1998

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Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis

Clinical immunology (Orlando, Fla.), 2003-02, Vol.106 (2), p.127-138

2003

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Soluble CD30 levels in plasma and cerebrospinal fluid in multiple sclerosis, HIV infection and other nervous system diseases

Acta neurologica Scandinavica, 1997-02, Vol.95 (2), p.99-102

1997

Volltextzugriff (PDF)

High levels of IL-10 secreting cells are present in blood in cerebrovascular diseases

European journal of neurology, 1999-07, Vol.6 (4), p.437-442

1999

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γ/δ T Cells in Multiple Sclerosis: Chemokine and Chemokine Receptor Expression

Clinical immunology (Orlando, Fla.), 2002-06, Vol.103 (3), p.309-316

2002

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Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

Journal of autoimmunity, 1999-06, Vol.12 (4), p.297-303

1999

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Autoantigen-induced IL-13 mRNA expression is increased in blood mononuclear cells in myasthenia gravis and multiple sclerosis

European journal of neurology, 1997-09, Vol.4 (5), p.468-475

1997

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Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis

European journal of immunology, 1998-11, Vol.28 (11), p.3587-3593

1998

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Tumor necrosis factor-α, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis

Journal of neuroimmunology, 1996-12, Vol.71 (1), p.191-198

1996

Volltextzugriff (PDF)

Tumor necrosis factor-alpha, lymphotoxin: Interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia

Journal of neuroimmunology, 1996-12, Vol.71 (1-2), p.191

1996

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Navigating the orphan medicinal product designation: Evidence requirements for gene therapies in Europe

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Biomarkers for Alzheimer's disease therapeutic trials

Monocyte‐derived cytokines in multiple sclerosis

Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers

IL‐15 mRNA expression is up‐regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS)

Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis

Effect of peppermint and thyme essential oil mist on performance and physiological parameters in broiler chickens

Interleukin‐12 and Perforin mRNA Expression is Augmented in Blood Mononuclear Cells in Multiple Sclerosis

Multiple sclerosis: the proinflammatory cytokines lymphotoxin-α and tumour necrosis factor-α are upregulated in cerebrospinal fluid mononuclear cells

Optic neuritis and cytokines: no relation to MRI abnormalities and oligoclonal bands

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Influence of IFN-β1b (Betaferon) on cytokine mRNA profiles in blood mononuclear cells and plasma levels of soluble VCAM-1 in multiple sclerosis

High numbers of perforin mRNA expressing CSF cells in multiple sclerosis patients with gadolinium-enhancing brain MRI lesions

Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA

Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis

Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis

Soluble CD30 levels in plasma and cerebrospinal fluid in multiple sclerosis, HIV infection and other nervous system diseases

High levels of IL-10 secreting cells are present in blood in cerebrovascular diseases

γ/δ T Cells in Multiple Sclerosis: Chemokine and Chemokine Receptor Expression

Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

Autoantigen-induced IL-13 mRNA expression is increased in blood mononuclear cells in myasthenia gravis and multiple sclerosis

Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis

Tumor necrosis factor-α, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis

Tumor necrosis factor-alpha, lymphotoxin: Interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia

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