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培養細胞を用いた老化研究—細胞が教えてくれたこと：細胞表面糖質の機能，働く胃粘膜細胞，細胞内シグナル，新規アダプター分子の発見，老化形質発現の可逆性，そしてそれ以上のもの

YAKUGAKU ZASSHI, 2023/09/01, Vol.143(9), pp.729-744

松岡, 耕二

2023

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Cultured Cells in the Aging Research, Exhibiting Cell Surface Component Functions, Intracellular Signaling, a Novel Adaptor Molecule, Aging Phenotype Expression and Various Aspects of the Cellular Physiology

YAKUGAKU ZASSHI, 2023/09/01, Vol.143(9), pp.729-744

Matuoka, Koozi

2023

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C3G, a Guanine Nucleotide-Releasing Protein Expressed Ubiquitously, Binds to the Src Homology 3 Domains of CRK and GRB2/ASH Proteins

Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (8), p.3443-3447

1994

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Nuclear Factor Y (NF-Y) and Cellular Senescence

Experimental Cell Research, 1999-12, Vol.253 (2), p.365-371

1999

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A Novel Ligand for an SH3 Domain of the Adaptor Protein Nck Bears an SH2 Domain and Nuclear Signaling Motifs

Biochemical and biophysical research communications, 1997-10, Vol.239 (2), p.488-492

1997

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Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins

The Journal of biological chemistry, 1996-06, Vol.271 (24), p.14468-14472

1996

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A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts

Archives of gerontology and geriatrics, 2003-05, Vol.36 (3), p.203-219

2003

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Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2

Science (American Association for the Advancement of Science), 1988-02, Vol.239 (4840), p.640-643

1988

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Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver

Journal of medicinal food, 2005-06, Vol.8 (2), p.184-189

2005

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Transcriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y

Ageing research reviews, 2002-09, Vol.1 (4), p.639-651

2002

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Splicing Isoforms of Rat Ash/Grb2

The Journal of biological chemistry, 1995-06, Vol.270 (23), p.13733-13739

1995

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Cloning of ASH, a Ubiquitous Protein Composed of One Src Homology Region (SH) 2 and Two SH3 Domains, from Human and Rat cDNA Libraries

Proceedings of the National Academy of Sciences - PNAS, 1992-10, Vol.89 (19), p.9015-9019

1992

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Diethylnitrosamine- and partial hepatectomy-induced decrease in ?2u-globulin mRNA level in the rat liver

Journal of cancer research and clinical oncology, 1993-10, Vol.119 (10), p.572-575

1993

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Cultured rabbit gastric epithelial cells producing prostaglandin I2

Gastroenterology (New York, N.Y. 1943), 1983-03, Vol.84 (3), p.498-505

1983

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Association of Ash/Grb-2 with dynamin through the Src homology 3 domain

The Journal of biological chemistry, 1994-02, Vol.269 (8), p.5489-5492

1994

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Possible role of subunit A of nuclearfactor Y (NF-YA) in normal human diploidfibroblasts during senescence

Biogerontology (Dordrecht), 2000-09, Vol.1 (3), p.261-271

2000

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Thyme (Thymus vulgaris L.) Leaves and Its Contituents Increase the Activities of Xenobiotic-Metabolizing Enzymes in Mouse Liver

Journal of Medicinal Food, 2005, 8(2), , pp.184-189

2005

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Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells

The Journal of biological chemistry, 1994-12, Vol.269 (49), p.31310-31314

1994

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Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents

Biogerontology (Dordrecht), 2002-01, Vol.3 (6), p.365-372

2002

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Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110α and WRN during fibroblast aging in vitro

Biochimica et biophysica acta, 1998-02, Vol.1401 (2), p.211-215

1998

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A decrease in hyaluronic acid synthesis by aging human fibroblasts leading to heparan sulfate enrichment and growth reduction

Aging clinical and experimental research, 1989-09, Vol.1 (1), p.47-54

1989

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Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells

The Journal of biological chemistry, 1994-01, Vol.269 (2), p.1143-1148

1994

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Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling

Genes to cells : devoted to molecular & cellular mechanisms, 2003-01, Vol.8 (1), p.29-40

2003

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Growth-regulating Factors on the Surface Membrane of Senescent Cells

TISSUE CULTURE RESEARCH COMMUNICATIONS, 1985/12/20, Vol.4(2), pp.128-134

1985

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Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

The Journal of biological chemistry, 1993-05, Vol.268 (15), p.11167-11171

1993

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培養細胞を用いた老化研究—細胞が教えてくれたこと：細胞表面糖質の機能，働く胃粘膜細胞，細胞内シグナル，新規アダプター分子の発見，老化形質発現の可逆性，そしてそれ以上のもの

Cultured Cells in the Aging Research, Exhibiting Cell Surface Component Functions, Intracellular Signaling, a Novel Adaptor Molecule, Aging Phenotype Expression and Various Aspects of the Cellular Physiology

C3G, a Guanine Nucleotide-Releasing Protein Expressed Ubiquitously, Binds to the Src Homology 3 Domains of CRK and GRB2/ASH Proteins

Nuclear Factor Y (NF-Y) and Cellular Senescence

A Novel Ligand for an SH3 Domain of the Adaptor Protein Nck Bears an SH2 Domain and Nuclear Signaling Motifs

Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins

A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts

Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2

Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver

Transcriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y

Splicing Isoforms of Rat Ash/Grb2

Cloning of ASH, a Ubiquitous Protein Composed of One Src Homology Region (SH) 2 and Two SH3 Domains, from Human and Rat cDNA Libraries

Diethylnitrosamine- and partial hepatectomy-induced decrease in ?2u-globulin mRNA level in the rat liver

Cultured rabbit gastric epithelial cells producing prostaglandin I2

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain

Possible role of subunit A of nuclearfactor Y (NF-YA) in normal human diploidfibroblasts during senescence

Thyme (Thymus vulgaris L.) Leaves and Its Contituents Increase the Activities of Xenobiotic-Metabolizing Enzymes in Mouse Liver

Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells

Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents

Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110α and WRN during fibroblast aging in vitro

A decrease in hyaluronic acid synthesis by aging human fibroblasts leading to heparan sulfate enrichment and growth reduction

Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells

Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling

Growth-regulating Factors on the Surface Membrane of Senescent Cells

Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2

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