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How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization

Mini reviews in medicinal chemistry, 2016-01, Vol.16 (5), p.358-369

2016

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Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

BMC cancer, 2015-08, Vol.15 (1), p.584-584, Article 584

2015

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Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma

PloS one, 2021-05, Vol.16 (5), p.e0252314-e0252314

2021

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A Fibroblast-Derived Secretome Stimulates the Growth and Invasiveness of 3D Plexiform Neurofibroma Spheroids

Cancers, 2024-07, Vol.16 (14), p.2498

2024

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Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation

Neoplasia (New York, N.Y.), 2018-09, Vol.20 (9), p.951-963

2018

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Ras and Rap1: A tale of two GTPases

Seminars in cancer biology, 2019-02, Vol.54, p.29-39

2019

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Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

Neoplasia (New York, N.Y.), 2013-10, Vol.15 (10), p.1125-IN9

2013

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Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Neoplasia (New York, N.Y.), 2008-12, Vol.10 (12), p.1444-1458

2008

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Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Breast cancer research : BCR, 2017-05, Vol.19 (1), p.56-56, Article 56

2017

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Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers

Cancers, 2023-12, Vol.16 (1), p.89

2023

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Ang II acutely stimulates Na,K‐pump in cells from proximal tubules by increasing its phosphorylation at S938 via a PI3K/AKT pathway

Physiological reports, 2022-11, Vol.10 (21), p.e15508-n/a

2022

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Tyrosyl Phosphorylated PAK1 Regulates Breast Cancer Cell Motility in Response to Prolactin through Filamin A

Molecular endocrinology (Baltimore, Md.), 2013-03, Vol.27 (3), p.455-465

2013

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RNA-Seq of human breast ductal carcinoma in situ models reveals aldehyde dehydrogenase isoform 5A1 as a novel potential target

PloS one, 2012-12, Vol.7 (12), p.e50249-e50249

2012

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Modeling Tumor: Lymphatic Interactions in Lymphatic Metastasis of Triple Negative Breast Cancer

Cancers, 2021-11, Vol.13 (23), p.6044

2021

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Electrical stimulation of Schwann cells on electrospun hyaluronic acid carbon nanotube fibers

PloS one, 2024-08, Vol.19 (8), p.e0308207

2024

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p21-Activated Kinase 1 Coordinates Aberrant Cell Survival and Pericellular Proteolysis in a Three-Dimensional Culture Model for Premalignant Progression of Human Breast Cancer

Neoplasia (New York, N.Y.), 2008-04, Vol.10 (4), p.314,IN1-328,IN1

2008

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At low levels, inorganic mercury interference with antigen signaling is associated with modifications to a panel of novel phosphoserine sites in B cell receptor pathway proteins

Toxicology in vitro, 2023-06, Vol.89, p.105564-105564, Article 105564

2023

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Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening

Experimental neurology, 2018-01, Vol.299 (Pt B), p.289-298

2018

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In Vitro Models for Studying Invasive Transitions of Ductal Carcinoma In Situ

Journal of mammary gland biology and neoplasia, 2019-03, Vol.24 (1), p.1-15

2019

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Spatio-temporal modeling and live-cell imaging of proteolysis in the 4D microenvironment of breast cancer

Cancer and metastasis reviews, 2019-09, Vol.38 (3), p.445-454

2019

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Angiotensin II-dependent phosphorylation at Ser11/Ser18 and Ser938 shifts the E2 conformations of rat kidney Na+/K+-ATPase

Biochemical journal, 2012-04, Vol.443 (1), p.249-258

2012

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Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.821-828

2010

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The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology

Molecular biology of the cell, 2006-05, Vol.17 (5), p.2177-2189

2006

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High RhoA Activity Maintains the Undifferentiated Mesenchymal Cell Phenotype, Whereas RhoA Down-Regulation by Laminin-2 Induces Smooth Muscle Myogenesis

The Journal of cell biology, 2002-03, Vol.156 (5), p.893-903

2002

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The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

The Journal of pharmacology and experimental therapeutics, 2006-01, Vol.316 (1), p.456-465

2006

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How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization

Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma

A Fibroblast-Derived Secretome Stimulates the Growth and Invasiveness of 3D Plexiform Neurofibroma Spheroids

Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation

Ras and Rap1: A tale of two GTPases

Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers

Ang II acutely stimulates Na,K‐pump in cells from proximal tubules by increasing its phosphorylation at S938 via a PI3K/AKT pathway

Tyrosyl Phosphorylated PAK1 Regulates Breast Cancer Cell Motility in Response to Prolactin through Filamin A

RNA-Seq of human breast ductal carcinoma in situ models reveals aldehyde dehydrogenase isoform 5A1 as a novel potential target

Modeling Tumor: Lymphatic Interactions in Lymphatic Metastasis of Triple Negative Breast Cancer

Electrical stimulation of Schwann cells on electrospun hyaluronic acid carbon nanotube fibers

p21-Activated Kinase 1 Coordinates Aberrant Cell Survival and Pericellular Proteolysis in a Three-Dimensional Culture Model for Premalignant Progression of Human Breast Cancer

At low levels, inorganic mercury interference with antigen signaling is associated with modifications to a panel of novel phosphoserine sites in B cell receptor pathway proteins

Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening

In Vitro Models for Studying Invasive Transitions of Ductal Carcinoma In Situ

Spatio-temporal modeling and live-cell imaging of proteolysis in the 4D microenvironment of breast cancer

Angiotensin II-dependent phosphorylation at Ser11/Ser18 and Ser938 shifts the E2 conformations of rat kidney Na+/K+-ATPase

Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors

The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology

High RhoA Activity Maintains the Undifferentiated Mesenchymal Cell Phenotype, Whereas RhoA Down-Regulation by Laminin-2 Induces Smooth Muscle Myogenesis

The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

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