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p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis

PloS one, 2013-10, Vol.8 (10), p.e77670-e77670

2013

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Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish

Journal of pediatric gastroenterology and nutrition, 2016-11, Vol.63 (5), p.524-530

2016

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Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

PloS one, 2016-03, Vol.11 (3), p.e0151521-e0151521

2016

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Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV

Clinical and translational science, 2021-09, Vol.14 (5), p.1935-1944

2021

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The microRNA-30 Family Is Required for Vertebrate Hepatobiliary Development

Gastroenterology (New York, N.Y. 1943), 2009-03, Vol.136 (3), p.1081-1090

2009

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Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

Development (Cambridge), 2004-11, Vol.131 (22), p.5753-5766

2004

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Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition

Hepatology (Baltimore, Md.), 2014-11, Vol.60 (5), p.1581-1592

2014

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CCBE1 mutation in two siblings, one manifesting lymphedema-cholestasis syndrome, and the other, fetal hydrops

PloS one, 2013-09, Vol.8 (9), p.e75770-e75770

2013

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Disruption of planar cell polarity activity leads to developmental biliary defects

Developmental biology, 2011-03, Vol.351 (2), p.229-241

2011

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Safety and pharmacokinetics of islatravir subdermal implant for HIV-1 pre-exposure prophylaxis: a randomized, placebo-controlled phase 1 trial

Nature medicine, 2021-10, Vol.27 (10), p.1712-1717

2021

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Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6

Development (Cambridge), 2005-12, Vol.132 (23), p.5295-5306

2005

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Considerations for Cell and Gene Therapy Programs Entering the Clinical Space

Clinical pharmacology and therapeutics, 2023-09, Vol.114 (3), p.569-577

2023

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Safety and Pharmacokinetics of Islatravir in Individuals with Severe Renal Insufficiency

Antimicrobial agents and chemotherapy, 2022-12, Vol.66 (12), p.e0093122

2022

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A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection

Journal of acquired immune deficiency syndromes (1999), 2023-04, Vol.92 (4), p.310

2023

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Safety and Pharmacokinetics of Once-Daily Multiple-Dose Administration of Islatravir in Adults Without HIV

Journal of acquired immune deficiency syndromes (1999), 2021-11, Vol.88 (3), p.314

2021

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Evidence From Human and Zebrafish That GPC1 Is a Biliary Atresia Susceptibility Gene

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.1107-1115.e3

2013

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Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma

Journal of pharmaceutical and biomedical analysis, 2022-04, Vol.212, p.114639-114639, Article 114639

2022

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Population Pharmacokinetics and Pharmacodynamics of Bezlotoxumab in Adults with Primary and Recurrent Clostridium difficile Infection

Antimicrobial agents and chemotherapy, 2019-02, Vol.63 (2)

2019

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Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial

The lancet HIV, 2020-03, Vol.7 (3), p.e164-e172

2020

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761 Zebrafish Studies Show That Add3, Not Xpnpep1, Is a Biliary Atresia Risk Gene

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-926-S-926

2014

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A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV

Clinical drug investigation, 2021-07, Vol.41 (7), p.629-638

2021

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DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia

Hepatology (Baltimore, Md.), 2011-03, Vol.53 (3), p.905-914

2011

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Lack of a Clinically Meaningful Drug Interaction Between the HIV‐1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate

Clinical pharmacology in drug development, 2021-12, Vol.10 (12), p.1432-1441

2021

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Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish

Developmental dynamics, 2008-01, Vol.237 (1), p.124-131

2008

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p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis

Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish

Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

Safety, tolerability, and pharmacokinetics of single‐ and multiple‐dose administration of islatravir (MK‐8591) in adults without HIV

The microRNA-30 Family Is Required for Vertebrate Hepatobiliary Development

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition

CCBE1 mutation in two siblings, one manifesting lymphedema-cholestasis syndrome, and the other, fetal hydrops

Disruption of planar cell polarity activity leads to developmental biliary defects

Safety and pharmacokinetics of islatravir subdermal implant for HIV-1 pre-exposure prophylaxis: a randomized, placebo-controlled phase 1 trial

Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6

Considerations for Cell and Gene Therapy Programs Entering the Clinical Space

Safety and Pharmacokinetics of Islatravir in Individuals with Severe Renal Insufficiency

A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection

Safety and Pharmacokinetics of Once-Daily Multiple-Dose Administration of Islatravir in Adults Without HIV

Evidence From Human and Zebrafish That GPC1 Is a Biliary Atresia Susceptibility Gene

Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma

Population Pharmacokinetics and Pharmacodynamics of Bezlotoxumab in Adults with Primary and Recurrent Clostridium difficile Infection

Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial

761 Zebrafish Studies Show That Add3, Not Xpnpep1, Is a Biliary Atresia Risk Gene

Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV

DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia

Lack of a Clinically Meaningful Drug Interaction Between the HIV‐1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate

Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish

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