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Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6694-6699

2012

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Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

Journal of neuroimmunology, 2001-03, Vol.114 (1), p.107-113

2001

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CD9 plays a role in Schwann cell migration in vitro

The Journal of neuroscience, 1995-01, Vol.15 (1), p.584-595

1995

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The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6688-6693

2012

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Impairment of the Blood–Nerve and Blood–Brain Barriers in Apolipoprotein E Knockout Mice

Experimental neurology, 2001-05, Vol.169 (1), p.13-22

2001

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Nerve Growth Factor and Its Low-Affinity Receptor Promote Schwann Cell Migration

Proceedings of the National Academy of Sciences - PNAS, 1994-03, Vol.91 (7), p.2795-2799

1994

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Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth

The Journal of neuroscience, 1996-08, Vol.16 (15), p.4673-4683

1996

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Apolipoprotein E suppresses glial cell secretion of TNF α

Journal of neuroimmunology, 1997-06, Vol.76 (1), p.70-74

1997

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Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

The Journal of neuroscience, 1997-08, Vol.17 (16), p.6114-6121

1997

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Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production

Neuroreport, 1998-03, Vol.9 (4), p.615-618

1998

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Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice

Experimental neurology, 1998-09, Vol.153 (1), p.156-163

1998

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Merosin Promotes Neurite Growth and Schwann Cell Migration in Vitro and Nerve Regeneration in Vivo: Evidence Using an Antibody to Merosin, ARM-1

Developmental biology, 1994-07, Vol.164 (1), p.133-146

1994

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Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology

Experimental neurology, 1995-12, Vol.136 (2), p.251-257

1995

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Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates

Development (Cambridge), 1995-05, Vol.121 (5), p.1301-1309

1995

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Identification of a Synaptic Vesicle-Specific Membrane Protein with a Wide Distribution in Neuronal and Neurosecretory Tissue

The Journal of cell biology, 1981-10, Vol.91 (1), p.257-269

1981

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Neurite Outgrowth Is Enhanced by Anti-Idiotypic Monoclonal Antibodies to the Ganglioside GM1

Experimental neurology, 1997-05, Vol.145 (1), p.278-287

1997

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Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies

Journal of immunological methods, 1987-06, Vol.100 (1), p.73-82

1987

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Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins

Glycobiology (Oxford), 1996-09, Vol.6 (6), p.581-589

1996

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Generating monoclonal antibodies to neuronal antigens

Journal of neuroscience methods, 1996-10, Vol.68 (2), p.235-245

1996

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The production of a monoclonal antibody that blocks the action of a neurite outgrowth-promoting factor

Cold Spring Harbor Symposia on Quantitative Biology, 1983-01, Vol.48 Pt 2, p.625-631

1983

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Immunopurification and characterization of a neuronal heparan sulfate proteoglycan

The Journal of neuroscience, 1985-07, Vol.5 (7), p.1842-1850

1985

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An in Vitro Neurite-Promoting Antigen Functions in Axonal Regeneration in vivo

Science (American Association for the Advancement of Science), 1987-09, Vol.237 (4822), p.1605-1608

1987

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Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve

Brain research, 1987-11, Vol.425 (2), p.360-363

1987

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Neuregulins as potential drugs for neurological disorders

Cold Spring Harbor Symposia on Quantitative Biology, 1996, Vol.61, p.459

1996

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Development and application of an efficient procedure for converting mouse IgM into small, active fragments

Journal of immunological methods, 1982-01, Vol.50 (3), p.239-253

1982

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Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

CD9 plays a role in Schwann cell migration in vitro

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Impairment of the Blood–Nerve and Blood–Brain Barriers in Apolipoprotein E Knockout Mice

Nerve Growth Factor and Its Low-Affinity Receptor Promote Schwann Cell Migration

Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth

Apolipoprotein E suppresses glial cell secretion of TNF α

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production

Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice

Merosin Promotes Neurite Growth and Schwann Cell Migration in Vitro and Nerve Regeneration in Vivo: Evidence Using an Antibody to Merosin, ARM-1

Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology

Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates

Identification of a Synaptic Vesicle-Specific Membrane Protein with a Wide Distribution in Neuronal and Neurosecretory Tissue

Neurite Outgrowth Is Enhanced by Anti-Idiotypic Monoclonal Antibodies to the Ganglioside GM1

Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies

Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins

Generating monoclonal antibodies to neuronal antigens

The production of a monoclonal antibody that blocks the action of a neurite outgrowth-promoting factor

Immunopurification and characterization of a neuronal heparan sulfate proteoglycan

An in Vitro Neurite-Promoting Antigen Functions in Axonal Regeneration in vivo

Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve

Neuregulins as potential drugs for neurological disorders

Development and application of an efficient procedure for converting mouse IgM into small, active fragments

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