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Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10106-10115

2018

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Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

Biochimica et biophysica acta. Molecular basis of disease, 2020-01, Vol.1866 (1), p.165560-165560, Article 165560

2020

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An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

Kidney international, 2011-07, Vol.80 (1), p.68-78

2011

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Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

ChemMedChem, 2009-04, Vol.4 (4), p.680-686

2009

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Molecular recognition of ligands in dipeptidyl peptidase IV

Current topics in medicinal chemistry, 2007-03, Vol.7 (6), p.609

2007

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Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Frontiers in pharmacology, 2022-01, Vol.12, p.699535-699535

2022

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Asymmetric Synthesis of (S)-3-Amino-4-methoxy-butan-1-ol by Way of Reductive Amination

Organic process research & development, 2011-03, Vol.15 (2), p.353-359

2011

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A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Nature (London), 2024-01, Vol.625 (7995), p.572-577

2024

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Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Nature (London), 2024-01, Vol.625 (7996), p.E27-E27

2024

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A Real-World Perspective on Molecular Design

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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A novel antibiotic class targeting the lipopolysaccharide transporter

Nature (London), 2024-01, Vol.625 (7995), p.566-571

2024

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A Flavo-Thiazolio-Cyclophane as a Functional Model for Pyruvate Oxidase

Angewandte Chemie (International ed.), 1996-07, Vol.35 (12), p.1341-1344

1996

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ROCK: the Roche medicinal chemistry knowledge application – design, use and impact

Drug discovery today, 2011-08, Vol.16 (15), p.691-696

2011

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A Real-World Perspective on Molecular Design: Miniperspective

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Aryl- and heteroaryl-substituted aminobenzo[ a]quinolizines as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1106-1108

2010

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Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4627-4632

2013

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1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (11), p.2966-2970

2007

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Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase

Journal of the American Chemical Society, 1999-03, Vol.121 (8), p.1756-1757

1999

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Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3446-3449

2005

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Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

ChemMedChem, 2006-01, Vol.1 (1), p.45-48

2006

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Ein Flavo-Thiazolio-Cyclophan als funktionsfähiges Modell für die Pyruvat-Oxidase

Angewandte Chemie, 1996-06, Vol.108 (12), p.1434-1437

1996

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Catalytic Cyclophanes. Part XI. A flavo-thiazolio-cyclophane as a biomimetic catalyst for the preparative-scale electro-oxidation of aromatic aldehydes to methyl esters

Helvetica chimica acta, 1997-08, Vol.80 (5), p.1555-1588

1997

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Bacillus subtilis chorismate mutase is partially diffusion‐controlled

European journal of biochemistry, 1999-04, Vol.261 (1), p.25-32

1999

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Ein Flavo‐Thiazolio‐Cyclophan als funktionsfähiges Modell für die Pyruvat‐Oxidase

Angewandte Chemie, 1996-06, Vol.108 (12), p.1434-1437

1996

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Cyclophane receptors with covalently bound coenzymes: Synthesis and biomimetic catalysis

Mattei, Patrizio

1997

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Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs

Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

Molecular recognition of ligands in dipeptidyl peptidase IV

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Asymmetric Synthesis of (S)-3-Amino-4-methoxy-butan-1-ol by Way of Reductive Amination

A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter

A Real-World Perspective on Molecular Design

A novel antibiotic class targeting the lipopolysaccharide transporter

A Flavo-Thiazolio-Cyclophane as a Functional Model for Pyruvate Oxidase

ROCK: the Roche medicinal chemistry knowledge application – design, use and impact

A Real-World Perspective on Molecular Design: Miniperspective

Aryl- and heteroaryl-substituted aminobenzo[ a]quinolizines as dipeptidyl peptidase IV inhibitors

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

Heavy Atom Isotope Effects Reveal a Highly Polarized Transition State for Chorismate Mutase

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Ein Flavo-Thiazolio-Cyclophan als funktionsfähiges Modell für die Pyruvat-Oxidase

Catalytic Cyclophanes. Part XI. A flavo-thiazolio-cyclophane as a biomimetic catalyst for the preparative-scale electro-oxidation of aromatic aldehydes to methyl esters

Bacillus subtilis chorismate mutase is partially diffusion‐controlled

Ein Flavo‐Thiazolio‐Cyclophan als funktionsfähiges Modell für die Pyruvat‐Oxidase

Cyclophane receptors with covalently bound coenzymes: Synthesis and biomimetic catalysis

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