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Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor

Chemical and Pharmaceutical Bulletin, 2018/03/01, Vol.66(3), pp.251-262

2018

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Abstract 2586: ASP8273 selectively inhibits mutant EGFR signal pathway and induces tumor shrinkage in EGFR mutated tumor models

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2586-2586

2015

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Abstract B188: Preclinical antitumor activity of ASP8273, a mutant-selective irreversible EGFR inhibitor in an AXL-overexpressing NSCLC model

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.B188-B188

2015

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Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice

Biological psychiatry (1969), 2007-07, Vol.62 (2), p.148-157

2007

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Radiosynthesis, biodistribution and imaging of [11 C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model

Nuclear medicine and biology, 2013-02, Vol.40 (2), p.221-226

2013

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Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

Journal of Pharmacological Sciences, 2007, Vol.103(3), pp.329-332

2007

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Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Neuroreport, 2006-09, Vol.17 (13), p.1453-1457

2006

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Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression

Molecular cancer therapeutics, 2019-08, Vol.18 (8), p.1366-1373

2019

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Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

The Journal of nuclear medicine (1978), 2008-07, Vol.49 (7), p.1183

2008

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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (8), p.1683-1692

2019

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Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma

Leukemia research, 2020-01, Vol.88, p.106286, Article 106286

2020

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Quantitation of cardiac sympathetic innervation in rabbits using 11C-hydroxyephedrine PET: relation to 123I-MIBG uptake

European journal of nuclear medicine and molecular imaging, 2006-08, Vol.33 (8), p.871-878

2006

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Abstract 1728: ASP8273, a novel mutant-selective irreversible EGFR inhibitor, inhibits growth of non-small cell lung cancer (NSCLC) cells with EGFR activating and T790M resistance mutations

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1728-1728

2014

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Brain Adenosine A^sub 2A^ Receptor Occupancy by a Novel A^sub 1^/A^sub 2A^ Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

The Journal of nuclear medicine (1978), 2008-07, Vol.49 (7), p.1183

2008

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Brain Adenosine A 2A Receptor Occupancy by a Novel A 1 /A 2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

Journal of Nuclear Medicine, 2008-07, Vol.49 (7), p.1183-1188

2008

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Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain

Nuclear medicine and biology, 2005-11, Vol.32 (8), p.837-844

2005

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Original Article: Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice

Biological psychiatry (1969), 2007-07, Vol.62 (2), p.148-157

2007

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Imidoyl Radicals as Synthons of Unstable Acyl Radicals

Journal of organic chemistry, 2001-03, Vol.66 (6), p.2183-2185

2001

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Synthesis and evaluation of [ 11C]FR194921 as a nonxanthine-type PET tracer for adenosine A 1 receptors in the brain

Nuclear medicine and biology, 2005, Vol.32 (8), p.837-844

2005

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Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides: A New Synthetic Method for Preparation of Selenoimidates

Journal of organic chemistry, 2000-08, Vol.65 (16), p.5022-5025

2000

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Synthesis and evaluation of [11C]RU40555, a selective glucocorticoid receptor antagonist

Journal of labelled compounds & radiopharmaceuticals, 2005-08, Vol.48 (9), p.657-668

2005

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A new synthesis of isoselenoureas by imidoylation of amines with selenium and isocyanides

Tetrahedron, 1997-09, Vol.53 (36), p.12159-12166

1997

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Selenium-Assisted One-Pot Synthesis of Carbodiimides from Isocyanides and Primary Amines

Synlett, 1999, Vol.1999 (1), p.75-76

Fujiwara, Shin-ichi

1999

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Imidoyl Radicals as Synthons of Unstable Acyl Radicals

ChemInform, 2001-07, Vol.32 (29), p.52-52

2001

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ChemInform Abstract: Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides: A New Synthetic Method for Preparation of Selenoimidates

ChemInform, 2000-11, Vol.31 (48), p.no-no

2000

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Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor

Abstract 2586: ASP8273 selectively inhibits mutant EGFR signal pathway and induces tumor shrinkage in EGFR mutated tumor models

Abstract B188: Preclinical antitumor activity of ASP8273, a mutant-selective irreversible EGFR inhibitor in an AXL-overexpressing NSCLC model

Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice

Radiosynthesis, biodistribution and imaging of [11 C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model

Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression

Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma

Quantitation of cardiac sympathetic innervation in rabbits using 11C-hydroxyephedrine PET: relation to 123I-MIBG uptake

Abstract 1728: ASP8273, a novel mutant-selective irreversible EGFR inhibitor, inhibits growth of non-small cell lung cancer (NSCLC) cells with EGFR activating and T790M resistance mutations

Brain Adenosine A^sub 2A^ Receptor Occupancy by a Novel A^sub 1^/A^sub 2A^ Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

Brain Adenosine A 2A Receptor Occupancy by a Novel A 1 /A 2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect

Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain

Original Article: Neural Circuits Containing Pallidotegmental GABAergic Neurons are Involved in the Prepulse Inhibition of the Startle Reflex in Mice

Imidoyl Radicals as Synthons of Unstable Acyl Radicals

Synthesis and evaluation of [ 11C]FR194921 as a nonxanthine-type PET tracer for adenosine A 1 receptors in the brain

Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides: A New Synthetic Method for Preparation of Selenoimidates

Synthesis and evaluation of [11C]RU40555, a selective glucocorticoid receptor antagonist

A new synthesis of isoselenoureas by imidoylation of amines with selenium and isocyanides

Selenium-Assisted One-Pot Synthesis of Carbodiimides from Isocyanides and Primary Amines

Imidoyl Radicals as Synthons of Unstable Acyl Radicals

ChemInform Abstract: Imidoylation of Acidic Hydrocarbons with Selenium and Isocyanides: A New Synthetic Method for Preparation of Selenoimidates

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