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Assessing the potential of glucokinase activators in diabetes therapy

Nature reviews. Drug discovery, 2009-05, Vol.8 (5), p.399-416

Matschinsky, Franz M

2009

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Metabolic Signaling in Fuel-Induced Insulin Secretion

Cell metabolism, 2013-08, Vol.18 (2), p.162-185

2013

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The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

Frontiers in physiology, 2019-03, Vol.10, p.148-148

2019

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GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?

Trends in pharmacological sciences (Regular ed.), 2013-02, Vol.34 (2), p.90-99

Matschinsky, Franz M

2013

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Ethanol metabolism: The good, the bad, and the ugly

Medical hypotheses, 2020-07, Vol.140, p.109638-109638, Article 109638

2020

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Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis

Frontiers in physiology, 2021-04, Vol.12, p.658997-658997

2021

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Allosteric and substrate site effects of relevant amino acids on structural stability and flexibility of glutamate dehydrogenase-1 (GDH-1)

Biophysical journal, 2023-02, Vol.122 (3), p.203a-203a

2023

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Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice

PloS one, 2014-02, Vol.9 (2), p.e86815

2014

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Integration of Eukaryotic Energy Metabolism: The Intramitochondrial and Cytosolic Energy States ([ATP] f /[ADP] f [Pi])

International journal of molecular sciences, 2022-05, Vol.23 (10), p.5550

2022

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Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics

Diabetes (New York, N.Y.), 2002-12, Vol.51 Suppl 3, p.S394-S404

Matschinsky, Franz M

2002

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α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals

The Journal of clinical investigation, 2022-06, Vol.132 (11)

2022

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Metabolic homeostasis: oxidative phosphorylation and the metabolic requirements of higher plants and animals

Journal of applied physiology (1985), 2018-10, Vol.125 (4), p.1183-1192

2018

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Translation of Ludwig Boltzmann’s Paper “On the Relationship between the Second Fundamental Theorem of the Mechanical Theory of Heat and Probability Calculations Regarding the Conditions for Thermal Equilibrium” Sitzungberichte der Kaiserlichen Akademie der Wissenschaften. Mathematisch-Naturwissen Classe. Abt. II, LXXVI 1877, pp 373-435 (Wien. Ber. 1877, 76:373-435). Reprinted in Wiss. Abhandlungen, Vol. II, reprint 42, p. 164-223, Barth, Leipzig, 1909

Entropy (Basel, Switzerland), 2015-04, Vol.17 (4), p.1971-2009

2015

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Oxygen dependence of glucose sensing: role in glucose homeostasis and related pathology

Journal of applied physiology (1985), 2019-06, Vol.126 (6), p.1746-1755

2019

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Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain

Frontiers in physiology, 2020-10, Vol.11, p.584891-584891

2020

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Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome

Medical hypotheses, 2019-11, Vol.132, p.109375-109375, Article 109375

2019

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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Nature communications, 2017-02, Vol.8 (1), p.14295-14295, Article 14295

2017

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Reply to "Letter to the Editor: Two of the significant omissions from a 'general' model of respiratory energy transduction"

Journal of applied physiology (1985), 2019-04, Vol.126 (4), p.1172-1172

2019

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Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic β-cells

Journal of applied physiology (1985), 2018-08, Vol.125 (2), p.419-428

2018

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The microRNA-21–PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.12030-12035

2011

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Glucokinase activators for diabetes therapy: May 2010 status report

Diabetes care, 2011-05, Vol.34 Suppl 2 (5), p.S236-S243

2011

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The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

Diabetes (New York, N.Y.), 2006-01, Vol.55 (1), p.1-12

2006

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Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Diabetes (New York, N.Y.), 2017-07, Vol.66 (7), p.1901-1913

2017

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Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.3938-3951

2013

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Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (37), p.18684-18690

2019

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Assessing the potential of glucokinase activators in diabetes therapy

Metabolic Signaling in Fuel-Induced Insulin Secretion

The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?

Ethanol metabolism: The good, the bad, and the ugly

Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis

Allosteric and substrate site effects of relevant amino acids on structural stability and flexibility of glutamate dehydrogenase-1 (GDH-1)

Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice

Integration of Eukaryotic Energy Metabolism: The Intramitochondrial and Cytosolic Energy States ([ATP] f /[ADP] f [Pi])

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics

α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals

Metabolic homeostasis: oxidative phosphorylation and the metabolic requirements of higher plants and animals

Oxygen dependence of glucose sensing: role in glucose homeostasis and related pathology

Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain

Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Reply to "Letter to the Editor: Two of the significant omissions from a 'general' model of respiratory energy transduction"

Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic β-cells

The microRNA-21–PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death

Glucokinase activators for diabetes therapy: May 2010 status report

The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by γ-Hydroxybutyrate and Glycine

Allosteric modulation of β-cell M 3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice

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