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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The Journal of neuroscience, 2011-11, Vol.31 (46), p.16507-16516

2011

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8076-8100

2021

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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.3786-3797

2022

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115194, Article 115194

2020

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Jackson's Local Flaps in Head and Neck Reconstruction

3, 2022

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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3260-3268

2015

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GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6463-6466

2013

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GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6459-6462

2013

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Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

Journal of medicinal chemistry, 2005-06, Vol.48 (13), p.4200-4203

2005

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A general method for the preparation of 2,3,5-trisubstituted-furo[3,2- b]pyridines

Tetrahedron letters, 2003-01, Vol.44 (4), p.725-728

2003

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Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.167-170

2004

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Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4973-4973

2017

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Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3231-3231

2017

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Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4337-4341

2015

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Substituted furo[3,2- b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.167-170

2004

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Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4337-4341

2015

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Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Novel Potent 5-HT 1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N -[3-(1-Methyl-4-piperidinyl)-1 H -pyrrolo[3,2- b ]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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The future of ACS membership

Chemical & engineering news, 2021-07, p.34-34

Brian Mathes, chair, ACS Committee on Membership Affairs

2021

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug–Drug Interaction Risk Profile

Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)

Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Jackson's Local Flaps in Head and Neck Reconstruction

Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Two Prodrugs of Potent and Selective GluR5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain

A general method for the preparation of 2,3,5-trisubstituted-furo[3,2- b]pyridines

Ethyl (3S,4aR,6S,8aR)-6-(4-Ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso- quinoline-3-carboxylic Ester: A Prodrug of a GluR5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine

Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT1F receptor agonists

Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores

Substituted furo[3,2- b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain : 2005 American Chemical Society Award for Computers in Chemical and Pharmaceutical Research

Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Novel Potent 5-HT 1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N -[3-(1-Methyl-4-piperidinyl)-1 H -pyrrolo[3,2- b ]pyridin-5-yl]amides

The future of ACS membership

Ethyl (3S, 4aR, 6S, 8aR)-6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroisoquinoline-3-c arboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

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