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Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Journal of hepatology, 2013-09, Vol.59 (3), p.621-625

2013

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Polycystic Liver Disease: Advances in Understanding and Treatment

Annual review of pathology, 2022-01, Vol.17 (1), p.251-269

2022

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Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins

Hepatology (Baltimore, Md.), 2022-05, Vol.75 (5), p.1110-1122

2022

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Therapeutic Targets in Polycystic Liver Disease

Current drug targets, 2017-01, Vol.18 (8), p.950-957

2017

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Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Hepatology (Baltimore, Md.), 2018-06, Vol.67 (6), p.2462-2464

2018

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Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Hepatology (Baltimore, Md.), 2018-03, Vol.67 (3), p.1088-1108

2018

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Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

American journal of physiology: Gastrointestinal and liver physiology, 2013-06, Vol.304 (11), p.G1013-G1024

2013

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Concurrent Targeting of Vasopressin Receptor 2 and Somatostatin Receptors in Autosomal Dominant Polycystic Kidney Disease: A Promising Approach for Autosomal Dominant Polycystic Kidney Disease Treatment?

Clinical journal of the American Society of Nephrology, 2023-02, Vol.18 (2), p.154-156

2023

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Cholangiocyte primary cilia in liver health and disease

Developmental dynamics, 2008-08, Vol.237 (8), p.2007-2012

2008

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Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

The American journal of pathology, 2018-04, Vol.188 (4), p.981-994

2018

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Characterization of PKD Protein-Positive Exosome-Like Vesicles

Journal of the American Society of Nephrology, 2009-02, Vol.20 (2), p.278-288

2009

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Octreotide Inhibits Hepatic Cystogenesis in a Rodent Model of Polycystic Liver Disease by Reducing Cholangiocyte Adenosine 3′,5′-Cyclic Monophosphate

Gastroenterology (New York, N.Y. 1943), 2007-03, Vol.132 (3), p.1104-1116

2007

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Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

American journal of physiology: Gastrointestinal and liver physiology, 2010-10, Vol.299 (4), p.G990-G999

2010

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Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling

Hepatology (Baltimore, Md.), 2024-08

2024

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Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (48), p.19138-19143

2007

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HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis

The American journal of pathology, 2014-03, Vol.184 (3), p.600-608

2014

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Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

Hepatology (Baltimore, Md.), 2013-07, Vol.58 (1), p.409-421

2013

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TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Hepatology (Baltimore, Md.), 2017-10, Vol.66 (4), p.1197-1218

2017

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The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Hepatology (Baltimore, Md.), 2009-01, Vol.49 (1), p.160-174

2009

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TGR5 in the Cholangiociliopathies

Digestive diseases (Basel), 2015-01, Vol.33 (3), p.420-425

2015

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Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Gastroenterology (New York, N.Y. 1943), 2006-09, Vol.131 (3), p.911-920

2006

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Polycystic Liver Disease: The Benefits of Targeting cAMP

Clinical gastroenterology and hepatology, 2016-07, Vol.14 (7), p.1031-1034

2016

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Polycystic liver diseases: advanced insights into the molecular mechanisms

Nature reviews. Gastroenterology & hepatology, 2014-12, Vol.11 (12), p.750-761

2014

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Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement: A Randomized Clinical Trial

Clinical journal of the American Society of Nephrology, 2020-09, Vol.15 (9), p.1267-1278

2020

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Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Gastroenterology (New York, N.Y. 1943), 2010-07, Vol.139 (1), p.304-314.e2

2010

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Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Polycystic Liver Disease: Advances in Understanding and Treatment

Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins

Therapeutic Targets in Polycystic Liver Disease

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

Concurrent Targeting of Vasopressin Receptor 2 and Somatostatin Receptors in Autosomal Dominant Polycystic Kidney Disease: A Promising Approach for Autosomal Dominant Polycystic Kidney Disease Treatment?

Cholangiocyte primary cilia in liver health and disease

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Characterization of PKD Protein-Positive Exosome-Like Vesicles

Octreotide Inhibits Hepatic Cystogenesis in a Rodent Model of Polycystic Liver Disease by Reducing Cholangiocyte Adenosine 3′,5′-Cyclic Monophosphate

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis

Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

TGR5 in the Cholangiociliopathies

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Polycystic Liver Disease: The Benefits of Targeting cAMP

Polycystic liver diseases: advanced insights into the molecular mechanisms

Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement: A Randomized Clinical Trial

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

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