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Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research

Drug metabolism and disposition, 1999-10, Vol.27 (10), p.1117

1999

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Metabolic stability for drug discovery and development: Pharmacokinetic and biochemical challenges

Clinical pharmacokinetics, 2003-01, Vol.42 (6), p.515-528

2003

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Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis

Molecular pharmacology, 2001-04, Vol.59 (4), p.909-919

2001

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Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002-11, Vol.780 (2), p.205-215

2002

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Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s

Drug metabolism and disposition, 2001-01, Vol.29 (1), p.30

2001

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In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery

Combinatorial chemistry & high throughput screening, 2001-05, Vol.4 (3), p.245-263

2001

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Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans

Pharmaceutical research, 2006, Vol.23 (1), p.56-69

2006

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Molecular epidemiology of Plasmodium falciparum antifolate resistance in Vietnam: genotyping for resistance variants of dihydropteroate synthase and dihydrofolate reductase

International journal of antimicrobial agents, 1999-08, Vol.12 (3), p.203-211

1999

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Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6

European journal of clinical pharmacology, 1995-03, Vol.48 (1), p.35-38

1995

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Characterisation of praziquantel metabolism by rat liver microsomes using cytochrome P450 inhibitors

Biochemical pharmacology, 1994-11, Vol.48 (9), p.1779-1783

1994

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Genetic polymorphism of CYP2D6 and CYP2C19 in East- and Southern African populations including psychiatric patients

European journal of clinical pharmacology, 2001-04, Vol.57 (1), p.11-17

2001

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Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants

Brain Research Bulletin, 1997, Vol.44 (5), p.561-571

1997

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Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1218-1229

2004

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Low CYP1A2 activity in rural Shona children of Zimbabwe

Clinical pharmacology and therapeutics, 1995-01, Vol.57 (1), p.25-31

1995

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The effect of chloroquine on the pharmacokinetics and metabolism of praziquantel in rats and in humans

Biopharmaceutics & drug disposition, 1994-01, Vol.15 (1), p.33-43

1994

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Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.399-407

2002

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Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

European journal of clinical pharmacology, 2003-09, Vol.59 (5-6), p.429-442

2003

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Effects of phenobarbital and 3-methylcholanthrene pretreatment of the pharmacokinetics of praziquantel in rats

European journal of drug metabolism and pharmacokinetics, 1993-07, Vol.18 (3), p.261-264

1993

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Combining pharmacophore and protein modeling to predict CYP450 inhibitors and substrates

Methods in Enzymology, 2002, Vol.357, p.133-144

2002

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Exploration of Enzyme−Ligand Interactions in CYP2D6 & 3A4 Homology Models and Crystal Structures Using a Novel Computational Approach

Journal of chemical information and modeling, 2007-05, Vol.47 (3), p.1234-1247

2007

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Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors

Journal of medicinal chemistry, 2004-02, Vol.47 (4), p.907-914

2004

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Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Clinica chimica acta, 1997-09, Vol.265 (2), p.145-155

1997

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Lack of effect of chloroquine on the debrisoquine (CYP2D6) and S‐mephenytoin (CYP2C19) hydroxylation phenotypes

British journal of clinical pharmacology, 1996-04, Vol.41 (4), p.344-346

1996

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Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors

Journal of computer-aided molecular design, 2002-07, Vol.16 (7), p.443-458

2002

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The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant: Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations

Biochemical pharmacology, 2002-11, Vol.64 (9), p.1387-1398

2002

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Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research

Metabolic stability for drug discovery and development: Pharmacokinetic and biochemical challenges

Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis

Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions

Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s

In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery

Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans

Molecular epidemiology of Plasmodium falciparum antifolate resistance in Vietnam: genotyping for resistance variants of dihydropteroate synthase and dihydrofolate reductase

Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6

Characterisation of praziquantel metabolism by rat liver microsomes using cytochrome P450 inhibitors

Genetic polymorphism of CYP2D6 and CYP2C19 in East- and Southern African populations including psychiatric patients

Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques

Low CYP1A2 activity in rural Shona children of Zimbabwe

The effect of chloroquine on the pharmacokinetics and metabolism of praziquantel in rats and in humans

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

Effects of phenobarbital and 3-methylcholanthrene pretreatment of the pharmacokinetics of praziquantel in rats

Combining pharmacophore and protein modeling to predict CYP450 inhibitors and substrates

Exploration of Enzyme−Ligand Interactions in CYP2D6 & 3A4 Homology Models and Crystal Structures Using a Novel Computational Approach

Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors

Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A

Lack of effect of chloroquine on the debrisoquine (CYP2D6) and S‐mephenytoin (CYP2C19) hydroxylation phenotypes

Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors

The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant: Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations

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