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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients

Communications medicine, 2023-10, Vol.3 (1), p.154-154, Article 154

2023

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Electrophysiologic characterization of a novel hERG channel activator

Biochemical pharmacology, 2009-04, Vol.77 (8), p.1383-1390

2009

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The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block

Journal of cardiovascular pharmacology, 2004-03, Vol.43 (3), p.369-379

2004

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In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY)

International journal of pharmaceutics, 2023-04, Vol.636, p.122842-122842, Article 122842

2023

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Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Toxicologic pathology, 2006-01, Vol.34 (1), p.81-90

2006

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The [ 3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K +] o

Journal of pharmacological and toxicological methods, 2004-11, Vol.50 (3), p.187-199

2004

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Discovery of A‑910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor

Journal of medicinal chemistry, 2024-10, Vol.67 (19), p.17000-17032

2024

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Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors

Current drug safety, 2011-11, Vol.6 (5), p.277-284

2011

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Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Journal of pharmacological and toxicological methods, 2020-05, Vol.103, p.106871, Article 106871

2020

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Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1584-1597

2007

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BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

Science advances, 2024-10, Vol.10 (40), p.eado7120

2024

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BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

Science advances, 2024-10, Vol.10 (40), p.eado7120

2024

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Mibefradil block of cloned T-type calcium channels

The Journal of pharmacology and experimental therapeutics, 2000-10, Vol.295 (1), p.302

2000

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Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Journal of medicinal chemistry, 2007-06, Vol.50 (13), p.2990-3003

2007

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Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers

Life sciences (1973), 2012-04, Vol.90 (15-16), p.607-611

2012

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Functional consequences of methionine oxidation of hERG potassium channels

Biochemical pharmacology, 2007-09, Vol.74 (5), p.702-711

2007

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A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Biochemical pharmacology, 2010-10, Vol.80 (7), p.1000-1006

2010

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Block of hERG channel by ziprasidone: Biophysical properties and molecular determinants

Biochemical pharmacology, 2006-01, Vol.71 (3), p.278-286

2006

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In vitro studies on a class of quinoline containing histamine H3 antagonists

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3295-3300

2010

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In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience

Journal of cardiovascular pharmacology, 2006-11, Vol.48 (5), p.199-206

2006

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Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels

Inflammation research, 2011-07, Vol.60 (7), p.683-693

2011

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Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

Inflammation research, 2011-07, Vol.60 (7), p.683-693

2011

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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Electrophysiologic characterization of a novel hERG channel activator

The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block

In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY)

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

The [ 3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K +] o

Discovery of A‑910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor

Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Mibefradil block of cloned T-type calcium channels

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers

Functional consequences of methionine oxidation of hERG potassium channels

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Block of hERG channel by ziprasidone: Biophysical properties and molecular determinants

In vitro studies on a class of quinoline containing histamine H3 antagonists

1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience

Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels

Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

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