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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Nature communications, 2015-04, Vol.6 (1), p.6769-6769, Article 6769

2015

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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3741-3752

2019

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Recent Advances in Kinase Drug Discovery Part I: The Editors’ Take

International journal of molecular sciences, 2021-07, Vol.22 (14), p.7560

2021

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Structure-based discovery of cyclin-dependent protein kinase inhibitors

Essays in biochemistry, 2017-11, Vol.61 (5), p.439-452

2017

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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3768-3782

2013

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A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

Chembiochem : a European journal of chemical biology, 2012-09, Vol.13 (14), p.2128-2136

2012

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Molecular oncology, 2018-03, Vol.12 (3), p.287-304

2018

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Nature communications, 2020-10, Vol.11 (1), p.5047-5047, Article 5047

2020

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Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2474-2478

2012

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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

ACS chemical biology, 2012-04, Vol.7 (4), p.698-706

2012

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Exiting the tunnel of uncertainty: crystal soak to validated hit

Acta crystallographica. Section D, Biological crystallography., 2022-11, Vol.78 (11), p.1294-1302

2022

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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Cell chemical biology, 2019-01, Vol.26 (1), p.121-130.e5

2019

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Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

ACS chemical biology, 2013-11, Vol.8 (11), p.2360-2365

2013

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Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4491-4502

2023

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Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7863-7875

2017

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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1746-1767

2017

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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

ACS chemical biology, 2014-05, Vol.9 (5), p.1160-1171

2014

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Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

Journal of proteome research, 2023-08, Vol.22 (8), p.2629-2640

2023

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Conformational study into N-alkyl-N′-aryl ureas to inform drug discovery

Bioorganic & medicinal chemistry, 2023-08, Vol.91, p.117387-117387, Article 117387

2023

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Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2

Molecules (Basel, Switzerland), 2015-01, Vol.20 (1), p.1643-1660

2015

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Digital Inclusion for Access to Information: A Study on Banking and Financial Institutions in India

SAGE open, 2017-09, Vol.7 (3)

2017

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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12324-12341

2023

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Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

MedChemComm, 2012-06, Vol.3 (6), p.699-709

2012

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Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11322-11339

2022

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Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions

Journal of medicinal chemistry, 2022-11, Vol.65 (22), p.15416-15432

2022

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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Recent Advances in Kinase Drug Discovery Part I: The Editors’ Take

Structure-based discovery of cyclin-dependent protein kinase inhibitors

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

Exiting the tunnel of uncertainty: crystal soak to validated hit

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

Conformational study into N-alkyl-N′-aryl ureas to inform drug discovery

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2

Digital Inclusion for Access to Information: A Study on Banking and Financial Institutions in India

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions

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