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Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

Biochemistry (Easton), 2018-05, Vol.57 (17), p.2478-2487

2018

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Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6478), p.694-699

2020

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Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof

Emerging topics in life sciences, 2020-12, Vol.4 (3), p.307-329

2020

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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Molecular cell, 2018-10, Vol.72 (1), p.19-36.e8

2018

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A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

The EMBO journal, 2018-03, Vol.37 (5), p.n/a

2018

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A multi-step nucleation process determines the kinetics of prion-like domain phase separation

Nature communications, 2021-07, Vol.12 (1), p.4513-4513, Article 4513

2021

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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

Nucleic acids research, 2021-03, Vol.49 (5), p.2931-2945

2021

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Dwelling at membranes promotes decisive signaling

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6431), p.1036-1037

2019

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Protein Network Structure Enables Switching between Liquid and Gel States

Journal of the American Chemical Society, 2020-01, Vol.142 (2), p.874-883

2020

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A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

Nature structural & molecular biology, 2017-08, Vol.24 (8), p.666-671

2017

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Prostasin Is Required for Matriptase Activation in Intestinal Epithelial Cells to Regulate Closure of the Paracellular Pathway

The Journal of biological chemistry, 2013-04, Vol.288 (15), p.10328-10337

2013

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Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains

Nature chemistry, 2022-02, Vol.14 (2), p.196-207

2022

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Proteolytic Activation of the Protease-activated Receptor (PAR)-2 by the Glycosylphosphatidylinositol-anchored Serine Protease Testisin

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3529-3541

2015

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G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Cell, 2020-04, Vol.181 (2), p.325-345.e28

2020

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Challenges of Decoding Transcription Factor Dynamics in Terms of Gene Regulation

Cells (Basel, Switzerland), 2018-09, Vol.7 (9), p.132

2018

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Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation

Journal of the American Chemical Society, 2016-11, Vol.138 (47), p.15323-15335

2016

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Assaying Homodimers of NF-κB in Live Single Cells

Frontiers in immunology, 2019-11, Vol.10, p.2609-2609

2019

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Co-encapsulating the fusogenic peptide INF7 and molecular imaging probes in liposomes increases intracellular signal and probe retention

PloS one, 2015-03, Vol.10 (3), p.e0120982-e0120982

2015

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Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET

Journal of the American Chemical Society, 2020-09, Vol.142 (37), p.15697-15710

2020

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Small-angle X-ray scattering experiments of monodisperse intrinsically disordered protein samples close to the solubility limit

Methods in enzymology, 2021-01, Vol.646, p.185-222

2021

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Integrative analysis suggests cell type–specific decoding of NF-κB dynamics

Science signaling, 2020-02, Vol.13 (620)

2020

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Walking Along a Protein Phase Diagram to Determine Coexistence Points by Static Light Scattering

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2141, p.715

2020

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Biomolecular Condensates as Novel Antiviral Targets

Journal of molecular biology, 2024-02, Vol.436 (4), p.168380-168380, Article 168380

2024

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Structural biases in disordered proteins are prevalent in the cell

Nature structural & molecular biology, 2024-02, Vol.31 (2), p.283-292

2024

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Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (28), p.e2201423119-e2201423119

2022

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Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

A multi-step nucleation process determines the kinetics of prion-like domain phase separation

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

Dwelling at membranes promotes decisive signaling

Protein Network Structure Enables Switching between Liquid and Gel States

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

Prostasin Is Required for Matriptase Activation in Intestinal Epithelial Cells to Regulate Closure of the Paracellular Pathway

Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains

Proteolytic Activation of the Protease-activated Receptor (PAR)-2 by the Glycosylphosphatidylinositol-anchored Serine Protease Testisin

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Challenges of Decoding Transcription Factor Dynamics in Terms of Gene Regulation

Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation

Assaying Homodimers of NF-κB in Live Single Cells

Co-encapsulating the fusogenic peptide INF7 and molecular imaging probes in liposomes increases intracellular signal and probe retention

Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET

Small-angle X-ray scattering experiments of monodisperse intrinsically disordered protein samples close to the solubility limit

Integrative analysis suggests cell type–specific decoding of NF-κB dynamics

Walking Along a Protein Phase Diagram to Determine Coexistence Points by Static Light Scattering

Biomolecular Condensates as Novel Antiviral Targets

Structural biases in disordered proteins are prevalent in the cell

Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases

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