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Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

mBio, 2017-05, Vol.8 (3)

2017

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Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

BMC cancer, 2019-06, Vol.19 (1), p.540-540, Article 540

2019

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A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

PloS one, 2016-10, Vol.11 (10), p.e0164632-e0164632

2016

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Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP

Human vaccines & immunotherapeutics, 2021-08, Vol.17 (8), p.2748-2761

2021

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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

Journal of leukocyte biology, 2003-06, Vol.73 (6), p.781-792

2003

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Using CATA and Machine Learning to Operationalize Old Constructs in New Ways: An Illustration Using U.S. Governors’ COVID-19 Press Briefings

Organizational research methods, 2023-10, Vol.26 (4), p.705-750

2023

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IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences

Blood, 2003-12, Vol.102 (13), p.4487-4492

2003

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Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

Gastroenterology (New York, N.Y. 1943), 2021-10, Vol.161 (4), p.1288-1302.e13

2021

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Human-robot collaboration: A multilevel and integrated leadership framework

The Leadership quarterly, 2022-02, Vol.33 (1), p.101594, Article 101594

2022

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Negative regulation of TLR9-mediated IFN-α induction by a small-molecule, synthetic TLR7 ligand

Journal of leukocyte biology, 2007-09, Vol.82 (3), p.497-508

2007

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Cross-neutralizing protection of vaginal and oral mucosa from HPV challenge by vaccination in a mouse model

Vaccine, 2023-07, Vol.41 (31), p.4480-4487

2023

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Identification of GLA/SE as an effective adjuvant for the induction of robust humoral and cell-mediated immune responses to EBV-gp350 in mice and rabbits

Vaccine, 2016-05, Vol.34 (23), p.2562-2569

2016

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In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant

Cytokine (Philadelphia, Pa.), 2016-07, Vol.83, p.99-109

2016

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Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists

Vaccine, 2021-01, Vol.39 (2), p.292-302

2021

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PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection

Molecular pharmaceutics, 2017-07, Vol.14 (7), p.2285-2293

2017

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Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine

Nanomedicine, 2021-04, Vol.33, p.102359-102359, Article 102359

2021

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Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir

Journal of virology, 2017-05, Vol.91 (9)

2017

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A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model

Vaccine, 2018-06, Vol.36 (28), p.4023-4031

2018

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Development of a robust, higher throughput green fluorescent protein (GFP)-based Epstein-Barr Virus (EBV) micro-neutralization assay

Journal of virological methods, 2017-09, Vol.247, p.15-21

2017

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Feasibility of Freeze-Drying Oil-in-Water Emulsion Adjuvants and Subunit Proteins to Enable Single-Vial Vaccine Drug Products

Journal of pharmaceutical sciences, 2017-06, Vol.106 (6), p.1490-1498

2017

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A minimal human immunostimulatory CpG motif that potently induces IFN‐γ and IFN‐α production

European journal of immunology, 2003-08, Vol.33 (8), p.2114-2122

2003

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Immunostimulatory DNA as a vaccine adjuvant

Expert review of vaccines, 2007-10, Vol.6 (5), p.747-759

2007

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Induction of interferon‐γ from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid‐dendritic‐cell‐produced interferon‐α and tumour necrosis factor‐α

Immunology, 2006-01, Vol.117 (1), p.38-46

2006

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Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes TH1 cytokine expression while downregulating TH2 cytokine expression in PBMCs from human patients with ragweed allergy

Journal of allergy and clinical immunology, 2001-08, Vol.108 (2), p.191-197

2001

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W1708 CpG-Containing Immunostimulatory Sequences (Iss) Exhibit Potent Inhibition of HCV Replication in HCV Replicon Line

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-836-A-836

2008

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Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

Using CATA and Machine Learning to Operationalize Old Constructs in New Ways: An Illustration Using U.S. Governors’ COVID-19 Press Briefings

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences

Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

Human-robot collaboration: A multilevel and integrated leadership framework

Negative regulation of TLR9-mediated IFN-α induction by a small-molecule, synthetic TLR7 ligand

Cross-neutralizing protection of vaginal and oral mucosa from HPV challenge by vaccination in a mouse model

Identification of GLA/SE as an effective adjuvant for the induction of robust humoral and cell-mediated immune responses to EBV-gp350 in mice and rabbits

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant

Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists

PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection

Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine

Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir

A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model

Development of a robust, higher throughput green fluorescent protein (GFP)-based Epstein-Barr Virus (EBV) micro-neutralization assay

Feasibility of Freeze-Drying Oil-in-Water Emulsion Adjuvants and Subunit Proteins to Enable Single-Vial Vaccine Drug Products

A minimal human immunostimulatory CpG motif that potently induces IFN‐γ and IFN‐α production

Immunostimulatory DNA as a vaccine adjuvant

Induction of interferon‐γ from natural killer cells by immunostimulatory CpG DNA is mediated through plasmacytoid‐dendritic‐cell‐produced interferon‐α and tumour necrosis factor‐α

Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes TH1 cytokine expression while downregulating TH2 cytokine expression in PBMCs from human patients with ragweed allergy

W1708 CpG-Containing Immunostimulatory Sequences (Iss) Exhibit Potent Inhibition of HCV Replication in HCV Replicon Line

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