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RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Molecular and Cellular Biology, 2006-05, Vol.26 (10), p.3853-3863

2006

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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

The Journal of pharmacology and experimental therapeutics, 2022-03, Vol.380 (3), p.210

2022

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The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7421-7425

2010

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Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10251-10284

2022

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Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.16213-16241

2021

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Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2143-2147

2018

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Catalytic Mapping of the Vibriobactin Biosynthetic Enzyme VibF

Biochemistry (Easton), 2002-01, Vol.41 (1), p.244-250

2002

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Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7334-7349

2011

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The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

Nature structural & molecular biology, 2002-07, Vol.9 (7), p.522-526

2002

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Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009

Proceedings of the National Academy of Sciences - PNAS, 2002-06, Vol.99 (13), p.8962-8967

2002

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Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (8), p.1968-1973

2014

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Carrier Protein Recognition in Siderophore-Producing Nonribosomal Peptide Synthetases

Biochemistry (Easton), 2002-07, Vol.41 (26), p.8429-8437

2002

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The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (6), p.1466-1471

2014

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Reconstitution and Characterization of the Vibrio cholerae Vibriobactin Synthetase from VibB, VibE, VibF, and VibH

Biochemistry (Easton), 2000-12, Vol.39 (50), p.15522-15530

2000

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Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

Archives of biochemistry and biophysics, 2009-04, Vol.484 (1), p.1-7

2009

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Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Nature (London), 2017-10, Vol.550 (7677), p.481-486

2017

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Heterocycle Formation in Vibriobactin Biosynthesis: Alternative Substrate Utilization and Identification of a Condensed Intermediate

Biochemistry (Easton), 2001-09, Vol.40 (35), p.10655-10663

2001

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Real-time bioluminescence imaging of polycythemia vera development in mice

Biochimica et biophysica acta, 2009-11, Vol.1792 (11), p.1073-1079

2009

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Discovery of 1-Amino-5 H -pyrido[4,3- b ]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7334-7349

2011

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Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

Current Opinion in Chemical Biology, 2001-10, Vol.5 (5), p.525-534

2001

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Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.5650-5650

2022

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RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306

Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction

Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Catalytic Mapping of the Vibriobactin Biosynthetic Enzyme VibF

Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009

Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms

Carrier Protein Recognition in Siderophore-Producing Nonribosomal Peptide Synthetases

The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization

Reconstitution and Characterization of the Vibrio cholerae Vibriobactin Synthetase from VibB, VibE, VibF, and VibH

Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Heterocycle Formation in Vibriobactin Biosynthesis: Alternative Substrate Utilization and Identification of a Condensed Intermediate

Real-time bioluminescence imaging of polycythemia vera development in mice

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Discovery of 1-Amino-5 H -pyrido[4,3- b ]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells

Discovery of a 5 H -Benzo[4,5]cyclohepta[1,2- b ]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer

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