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Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

Nature communications, 2020-10, Vol.11 (1), p.5415-5415, Article 5415

2020

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Development of a Novel Antibody-Drug Conjugate for the Potential Treatment of Ovarian, Lung, and Renal Cell Carcinoma Expressing TIM-1

Molecular cancer therapeutics, 2016-12, Vol.15 (12), p.2946-2954

2016

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Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy

Cancer Immunology, Immunotherapy, 2020-10, Vol.69 (10), p.2125-2137

2020

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Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy

Cancer Immunology, Immunotherapy, 2019-02, Vol.68 (2), p.233-245

2019

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Complement activation is critical for placental ischemia-induced hypertension in the rat

Molecular immunology, 2013-11, Vol.56 (1-2), p.91-97

2013

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Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine

Cellular & molecular immunology, 2015-11, Vol.12 (6), p.719-728

2015

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A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells

The Journal of immunology (1950), 2020-10, Vol.205 (7), p.1867-1877

2020

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CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways

Immuno, 2023-09, Vol.3 (3), p.273-288

2023

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Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass

Circulation (New York, N.Y.), 2004-09, Vol.110 (11), p.274-279

2004

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Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2000-09, Vol.20 (9), p.2106

2000

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Beneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery : Is there a gender difference?

Circulation (New York, N.Y.), 2007-09, Vol.116 (11), p.I83-I88

2007

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The Partly Folded Back Solution Structure Arrangement of the 30 SCR Domains in Human Complement Receptor Type 1 (CR1) Permits Access to its C3b and C4b Ligands

Journal of molecular biology, 2008-01, Vol.375 (1), p.102-118

2008

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CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy

The Journal of immunology (1950), 2017-12, Vol.199 (12), p.4110-4123

2017

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Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice

Cancer Immunology, Immunotherapy, 2022-01, Vol.71 (1), p.97-109

2022

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Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

Journal for immunotherapy of cancer, 2015-08, Vol.3 (1), p.37-37, Article 37

2015

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Soluble CR1 Therapy Improves Complement Regulation in C3 Glomerulopathy

Journal of the American Society of Nephrology, 2013-11, Vol.24 (11), p.1820-1829

2013

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Co-administration of a CpG adjuvant (VaxImmuneTM, CPG 7909) with CETP vaccines increased immunogenicity in rabbits and mice

Human vaccines, 2009-02, Vol.5 (2), p.79-84

2009

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Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

Science (American Association for the Advancement of Science), 1990-07, Vol.249 (4965), p.146-151

1990

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Abstract 4866: Development and characterization of novel CD40 antibody agonists for cancer immunotherapy

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4866-4866

2016

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Preclinical evaluation of the neuroprotective effect of soluble complement receptor Type 1 in a nonhuman primate model of reperfused stroke

Journal of neurosurgery, 2006-10, Vol.105 (4), p.595-601

2006

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Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology

Glycobiology (Oxford), 2004-10, Vol.14 (10), p.883-893

2004

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Synthesis and Complement Inhibitory Activity of B/C/D-Ring Analogues of the Fungal Metabolite 6,7-Diformyl-3‘,4‘,4a‘,5‘,6‘,7‘,8‘,8a‘-octahydro-4,6‘,7‘-trihydroxy- 2‘,5‘,5‘,8a‘-tetramethylspiro[1‘(2‘H)-naphthalene-2(3H)-benzofuran]

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2697-2705

2003

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A critical role of CD40 and CD70 signaling in cDC1s in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells

The Journal of immunology (1950), 2020-08, Vol.205 (7), p.1867-1877

2020

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Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers

Bone marrow transplantation (Basingstoke), 2015-07, Vol.50 (7), p.924-930

2015

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Abstract P5-04-03: Conversion of non-T cell-inflamed triple-negative breast cancer by in situ immunomodulation of induced intratumoral cross-presenting dendritic cells

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4_Supplement), p.P5-P5-04-03

2020

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Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

Development of a Novel Antibody-Drug Conjugate for the Potential Treatment of Ovarian, Lung, and Renal Cell Carcinoma Expressing TIM-1

Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy

Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy

Complement activation is critical for placental ischemia-induced hypertension in the rat

Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine

A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells

CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways

Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass

Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

Beneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery : Is there a gender difference?

The Partly Folded Back Solution Structure Arrangement of the 30 SCR Domains in Human Complement Receptor Type 1 (CR1) Permits Access to its C3b and C4b Ligands

CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy

Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

Soluble CR1 Therapy Improves Complement Regulation in C3 Glomerulopathy

Co-administration of a CpG adjuvant (VaxImmuneTM, CPG 7909) with CETP vaccines increased immunogenicity in rabbits and mice

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

Abstract 4866: Development and characterization of novel CD40 antibody agonists for cancer immunotherapy

Preclinical evaluation of the neuroprotective effect of soluble complement receptor Type 1 in a nonhuman primate model of reperfused stroke

Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology

Synthesis and Complement Inhibitory Activity of B/C/D-Ring Analogues of the Fungal Metabolite 6,7-Diformyl-3‘,4‘,4a‘,5‘,6‘,7‘,8‘,8a‘-octahydro-4,6‘,7‘-trihydroxy- 2‘,5‘,5‘,8a‘-tetramethylspiro[1‘(2‘H)-naphthalene-2(3H)-benzofuran]

A critical role of CD40 and CD70 signaling in cDC1s in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells

Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers

Abstract P5-04-03: Conversion of non-T cell-inflamed triple-negative breast cancer by in situ immunomodulation of induced intratumoral cross-presenting dendritic cells

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