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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

Acta neuropathologica, 2013-01, Vol.125 (1), p.133-144

2013

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CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease

Brain (London, England : 1878), 2015-08, Vol.138 (Pt 8), p.2383-2398

2015

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Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals

Current biology, 2018-01, Vol.28 (2), p.196-210.e4

2018

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Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

Nature communications, 2016-06, Vol.7 (1), p.11919-11919, Article 11919

2016

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Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes

Molecular neurodegeneration, 2014-12, Vol.9 (1), p.60-60, Article 60

2014

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Cholesterol and ApoE in Alzheimer’s disease

Oléagineux corps gras lipides, 2018-07, Vol.25 (4), p.D407

2018

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Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

Communications biology, 2023-02, Vol.6 (1), p.210-210, Article 210

2023

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Homodimerization of amyloid precursor protein at the plasma membrane: a homoFRET study by time-resolved fluorescence anisotropy imaging

PloS one, 2012-09, Vol.7 (9), p.e44434-e44434

2012

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Different Interactions between MT7 Toxin and the Human Muscarinic M1 Receptor in Its Free and N-Methylscopolamine-Occupied States

Molecular pharmacology, 2008-12, Vol.74 (6), p.1554-1563

2008

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Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

The FASEB journal, 2011-04, Vol.25 (4), p.1295-1305

2011

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Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides

Molecular neurobiology, 2022-11, Vol.59 (11), p.7056-7073

2022

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Triplication of Synaptojanin 1 in Alzheimer’s Disease Pathology in Down Syndrome

Current Alzheimer research, 2022-10, Vol.19 (12), p.795-807

2022

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Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

The European journal of neuroscience, 2015-05, Vol.41 (10), p.1345-1355

2015

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Identification of Various Allosteric Interaction Sites on M1 Muscarinic Receptor Using 125I-Met35-Oxidized Muscarinic Toxin 7

Molecular pharmacology, 2006-05, Vol.69 (5), p.1641-1651

2006

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Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

Cell reports (Cambridge), 2018-06, Vol.23 (10), p.2967-2975

2018

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Muscarinic toxins

Toxicon (Oxford), 2011-11, Vol.58 (6-7), p.455-463

2011

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Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C diseaseResearch in context

EBioMedicine, 2023-06, Vol.92, p.104628

2023

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Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2010-08, Vol.1801 (8), p.846-852

2010

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Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor

The Journal of biological chemistry, 2011-09, Vol.286 (36), p.31661-31675

2011

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Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease

EBioMedicine, 2023-06, Vol.92, p.104628-104628, Article 104628

2023

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Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes

Biochimica et biophysica acta, 2010-08, Vol.1801 (8), p.839-845

2010

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Polyoxomolybdates Functionalized with Phosphonocarboxylates

Inorganic chemistry, 2003-02, Vol.42 (4), p.1158-1162

2003

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Different Interactions between MT7 Toxin and the Human Muscarinic M 1 Receptor in Its Free and N -Methylscopolamine-Occupied States

Molecular pharmacology, 2008-12, Vol.74 (6), p.1554-1563

2008

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Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data

The Journal of biological chemistry, 2011-09, Vol.286 (36), p.31661-31675

2011

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

Acta neuropathologica, 2013-01, Vol.125 (1), p.133-144

2013

Volltextzugriff (PDF)

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease

Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals

Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes

Cholesterol and ApoE in Alzheimer’s disease

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

Homodimerization of amyloid precursor protein at the plasma membrane: a homoFRET study by time-resolved fluorescence anisotropy imaging

Different Interactions between MT7 Toxin and the Human Muscarinic M1 Receptor in Its Free and N-Methylscopolamine-Occupied States

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides

Triplication of Synaptojanin 1 in Alzheimer’s Disease Pathology in Down Syndrome

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

Identification of Various Allosteric Interaction Sites on M1 Muscarinic Receptor Using 125I-Met35-Oxidized Muscarinic Toxin 7

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

Muscarinic toxins

Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C diseaseResearch in context

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor

Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease

Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes

Polyoxomolybdates Functionalized with Phosphonocarboxylates

Different Interactions between MT7 Toxin and the Human Muscarinic M 1 Receptor in Its Free and N -Methylscopolamine-Occupied States

Structural Model of Ligand-G Protein-coupled Receptor (GPCR) Complex Based on Experimental Double Mutant Cycle Data

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

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