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Geometrically and Conformationally Restrained Cinnamoyl Compounds as Inhibitors of HIV-1 Integrase: Synthesis, Biological Evaluation, and Molecular Modeling

Journal of medicinal chemistry, 1998-10, Vol.41 (21), p.3948-3960

1998

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5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3H)-ones: Novel Potent and Selective Dihydro-alkoxy-benzyl-oxopyrimidine Derivatives

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.619-627

1999

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Derivatives of the New Ring System Indolo[1,2-c]benzo[1,2,3]triazine with Potent Antitumor and Antimicrobial Activity

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2561-2568

1999

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Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides

Journal of medicinal chemistry, 1992-03, Vol.35 (5), p.917-924

1992

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1,2,5-Benzothiadiazepine and Pyrrolo[2,1-d]-[1,2,5]Benzothiadiazepine Derivatives with Specific Anti-Human Immunodeficiency Virus Type 1 Activity

Antiviral chemistry & chemotherapy, 1998-03, Vol.9 (2), p.127-137

1998

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Synthesis and Biological Evaluation of 5H-Indolo [3,2-b][1,5]Benzothiazepine Derivatives, Designed as Conformationally Constrained Analogues of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor L-737,126

Antiviral Chemistry and Chemotherapy, 1998-03, Vol.9 (2), p.139-148

1998

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3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs): A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1

Antiviral chemistry & chemotherapy, 1993-12, Vol.4 (6), p.361-368

1993

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Structure—Activity Relationship Studies on New DABOs: Effect of Substitutions at Pyrimidine C-5 and C-6 Positions on Anti-HIV-1 Activity

Antiviral chemistry & chemotherapy, 2001-01, Vol.12 (1), p.37-50

2001

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Antimicrobial and antineoplastic activities of new 4-diazopyrazole derivatives

European journal of medicinal chemistry, 1998-06, Vol.33 (5), p.375-382

1998

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6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1745-1749

2004

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Anti-HIV-1 integrase drugs: how far from the shelf?

Current pharmaceutical design, 2000-03, Vol.6 (5), p.569-584

2000

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Native oligodeoxynucleotides specifically active against human immunodeficiency virus type 1 in vitro: a G-quartet-driven effect?

Antimicrobial Agents and Chemotherapy, 1996-09, Vol.40 (9), p.2034-2038

1996

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Structure-Activity Relationship Studies on Potential Non-Nucleoside DABO-Like Inhibitors of HIV-1 Reverse Transcriptase

Antiviral chemistry & chemotherapy, 2000-03, Vol.11 (2), p.117-133

2000

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Synthesis and antimicrobial activity of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles

Bioorganic & medicinal chemistry, 2000-12, Vol.8 (12), p.2719-2728

2000

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Potent and selective inhibitors of human immunodeficiency virus protease structurally related to L-694,746

Antiviral chemistry & chemotherapy, 1998-07, Vol.9 (4), p.303-309

1998

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Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogs of trichostatin A

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2845-2849

1990

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1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues

European journal of medicinal chemistry, 2001-12, Vol.36 (11), p.935-949

2001

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Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP + in PC12 pheochromocytoma cells: Binding and biological studies

Neuroscience letters, 1988-12, Vol.94 (3), p.349-354

1988

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Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors

The New microbiologica, 1994-10, Vol.17 (4), p.269

1994

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Modulatory effect of N-acetyl-L-cysteine on the HIV-1 multiplication in chronically and acutely infected cell lines

Antiviral research, 1993-09, Vol.22 (1), p.31-43

1993

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8-Aza Derivatives of 3-Deazapurine Nucleosides. Synthesis and in vitro Evaluation of Antiviral and Antitumor Activity

Antiviral chemistry & chemotherapy, 1993-12, Vol.4 (6), p.341-352

1993

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Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4t): A potent and selective inhibitor of human immunodeficiency virus

Biochemical pharmacology, 1988-12, Vol.37 (23), p.4419-4422

1988

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Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells

Biochemical pharmacology, 1990-05, Vol.39 (10), p.1523-1528

1990

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Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents

Farmaco (Società chimica italiana : 1989), 1997-11, Vol.52 (11), p.667

1997

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Enhancement of the anti-HIV-1 activity of ddAdo by coformycin, EHNA and deaza-EHNA derivatives

The New microbiologica, 1995-10, Vol.18 (4), p.359

1995

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Geometrically and Conformationally Restrained Cinnamoyl Compounds as Inhibitors of HIV-1 Integrase: Synthesis, Biological Evaluation, and Molecular Modeling

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3H)-ones: Novel Potent and Selective Dihydro-alkoxy-benzyl-oxopyrimidine Derivatives

Derivatives of the New Ring System Indolo[1,2-c]benzo[1,2,3]triazine with Potent Antitumor and Antimicrobial Activity

Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides

1,2,5-Benzothiadiazepine and Pyrrolo[2,1-d]-[1,2,5]Benzothiadiazepine Derivatives with Specific Anti-Human Immunodeficiency Virus Type 1 Activity

Synthesis and Biological Evaluation of 5H-Indolo [3,2-b][1,5]Benzothiazepine Derivatives, Designed as Conformationally Constrained Analogues of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor L-737,126

3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs): A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1

Structure—Activity Relationship Studies on New DABOs: Effect of Substitutions at Pyrimidine C-5 and C-6 Positions on Anti-HIV-1 Activity

Antimicrobial and antineoplastic activities of new 4-diazopyrazole derivatives

6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays

Anti-HIV-1 integrase drugs: how far from the shelf?

Native oligodeoxynucleotides specifically active against human immunodeficiency virus type 1 in vitro: a G-quartet-driven effect?

Structure-Activity Relationship Studies on Potential Non-Nucleoside DABO-Like Inhibitors of HIV-1 Reverse Transcriptase

Synthesis and antimicrobial activity of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles

Potent and selective inhibitors of human immunodeficiency virus protease structurally related to L-694,746

Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogs of trichostatin A

1,5-Benzodiazepines. Part XII. Synthesis and biological evaluation of tricyclic and tetracyclic 1,5-benzodiazepine derivatives as nevirapine analogues

Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP + in PC12 pheochromocytoma cells: Binding and biological studies

Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors

Modulatory effect of N-acetyl-L-cysteine on the HIV-1 multiplication in chronically and acutely infected cell lines

8-Aza Derivatives of 3-Deazapurine Nucleosides. Synthesis and in vitro Evaluation of Antiviral and Antitumor Activity

Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4t): A potent and selective inhibitor of human immunodeficiency virus

Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells

Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents

Enhancement of the anti-HIV-1 activity of ddAdo by coformycin, EHNA and deaza-EHNA derivatives

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