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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition

The Journal of pharmacology and experimental therapeutics, 2015-12, Vol.355 (3), p.397-409

2015

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Treatment window for hypothermia in brain injury

Journal of neurosurgery, 2001-12, Vol.95 (6), p.979-983

2001

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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity

The Journal of pharmacology and experimental therapeutics, 2021-04, Vol.377 (1), p.11-19

2021

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Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats

Stroke (1970), 1998-01, Vol.29 (1), p.152-158

1998

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Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106912, Article 106912

2020

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Abuse liability assessment for biologic drugs – All molecules are not created equal

Regulatory toxicology and pharmacology, 2018-02, Vol.92, p.165-172

2018

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Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.224-229

2014

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Comparison of methods for analysis of functional observation battery (FOB) data

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.89-94

2010

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The Safety Pharmacology Society salary survey

Journal of pharmacological and toxicological methods, 2017-11, Vol.88 (Pt 1), p.85-91

2017

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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

1, 2015

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Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds

Journal of pharmacological and toxicological methods, 2005-07, Vol.52 (1), p.159-167

2005

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Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats

Brain research, 1992-03, Vol.575 (2), p.238-246

1992

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Injury severity and sensitivity to treatment after controlled cortical impact in rats

Journal of neurotrauma, 2001-02, Vol.18 (2), p.175-186

2001

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Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats

Stroke (1970), 1994-01, Vol.25 (1), p.153-159

1994

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An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.246-246

2017

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Assessment of seizure liability of Org 306039, a 5-HT sub(2c) agonist, using hippocampal brain slice and rodent EEG telemetry

Journal of pharmacological and toxicological methods, 2014-02, Vol.70 (3), p.224-229

2014

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Overview of the joint PhRMA-FDA dialogue session on abuse potential assessment

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.223-224

2009

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EEG in monkey but not rat indentifies seizure potential of a pharmaceutical development candidate

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.e41-e42

2010

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Behavioral Recovery Patterns in Rats Receiving the NMDA Receptor Antagonist MDL 100,453 Immediately Post-Stroke

Pharmacology, biochemistry and behavior, 1997-03, Vol.56 (3), p.391-397

1997

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MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models

Life sciences (1973), 1998, Vol.63 (4), p.241-253

1998

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Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and wistar rats

Stroke (1970), 1993-02, Vol.24 (2), p.286-293

1993

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Nonclinical Assessment of Abuse Potential for New Pharmaceuticals in a Regulatory Space

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals, 2015

2015

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Chapter 1 - Nonclinical Assessment of Abuse Potential for New Pharmaceuticals in a Regulatory Space

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals, 2015, p.1-7

2015

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Glutamate antagonist MK-801 attenuates incomplete but not complete infarction in thrombotic distal middle cerebral artery occlusion in Wistar rats

Brain research, 1994-04, Vol.642 (1), p.117-122

1994

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Ibotenic acid lesions in the amygdaloid central nucleus but not in the lateral subthalamic area prevent the acquisition of differential Pavlovian conditioning of bradycardia in rabbits

Brain research, 1992-05, Vol.580 (1), p.155-163

1992

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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition

Treatment window for hypothermia in brain injury

Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity

Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats

Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery

Abuse liability assessment for biologic drugs – All molecules are not created equal

Assessment of seizure liability of Org 306039, a 5-HT2c agonist, using hippocampal brain slice and rodent EEG telemetry

Comparison of methods for analysis of functional observation battery (FOB) data

The Safety Pharmacology Society salary survey

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

Validation of a motor activity system by a robotically controlled vehicle and using standard reference compounds

Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats

Injury severity and sensitivity to treatment after controlled cortical impact in rats

Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats

An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)

Assessment of seizure liability of Org 306039, a 5-HT sub(2c) agonist, using hippocampal brain slice and rodent EEG telemetry

Overview of the joint PhRMA-FDA dialogue session on abuse potential assessment

EEG in monkey but not rat indentifies seizure potential of a pharmaceutical development candidate

Behavioral Recovery Patterns in Rats Receiving the NMDA Receptor Antagonist MDL 100,453 Immediately Post-Stroke

MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models

Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and wistar rats

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals in a Regulatory Space

Chapter 1 - Nonclinical Assessment of Abuse Potential for New Pharmaceuticals in a Regulatory Space

Glutamate antagonist MK-801 attenuates incomplete but not complete infarction in thrombotic distal middle cerebral artery occlusion in Wistar rats

Ibotenic acid lesions in the amygdaloid central nucleus but not in the lateral subthalamic area prevent the acquisition of differential Pavlovian conditioning of bradycardia in rabbits

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