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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.2047-2057

2014

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Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3747-3750

2012

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3627-3630

2013

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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1153-1163

2018

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Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (6), p.2212-2215

2012

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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

Biochemistry (Easton), 2003-01, Vol.42 (3), p.718-727

2003

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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3487-3490

2013

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Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors

Journal of medicinal chemistry, 2005-06, Vol.48 (12), p.3980-3990

2005

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Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2735-2738

2008

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Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1876-1879

2011

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Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1577-1582

2005

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Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3833-3838

2006

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Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (5), p.1692-1695

2008

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Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2289-2292

2007

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Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3367-3370

2006

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Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.125-128

2005

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A stereoselective totally synthetic route to methyl .alpha.-peracetylhikosaminide

Journal of the American Chemical Society, 1989-03, Vol.111 (6), p.2193-2204

1989

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Antitumor Activity of 9(R)-Dihydrotaxane Analogs

Journal of medicinal chemistry, 1995-04, Vol.38 (9), p.1482-1492

1995

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Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2655-2663

1994

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Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses of a mouse androgen and of a carbon-linked disaccharide

Journal of the American Chemical Society, 1985-03, Vol.107 (5), p.1256-1268

1985

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Synthesis of Ring B-Rearranged Taxane Analogs

Journal of organic chemistry, 1994-05, Vol.59 (9), p.2370-2373

1994

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SYNTHESIS AND IN VITRO ANTIBACTERIAL PROPERTIES OF ALKYLSPECTINOMYCIN ANALOGS

The Journal of Antibiotics, 1983, Vol.36(3), pp.339-342

1983

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An approach to the synthesis of carbon-carbon linked disaccharides

Journal of organic chemistry, 1984-11, Vol.49 (23), p.4564-4565

1984

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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase

Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors

Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase

Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety

Inhibitors of HCV NS5B polymerase: synthesis and structure–activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives

Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core

A stereoselective totally synthetic route to methyl .alpha.-peracetylhikosaminide

Antitumor Activity of 9(R)-Dihydrotaxane Analogs

Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol

Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses of a mouse androgen and of a carbon-linked disaccharide

Synthesis of Ring B-Rearranged Taxane Analogs

SYNTHESIS AND IN VITRO ANTIBACTERIAL PROPERTIES OF ALKYLSPECTINOMYCIN ANALOGS

An approach to the synthesis of carbon-carbon linked disaccharides

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