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Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

International journal of molecular sciences, 2018-11, Vol.19 (11), p.3480

2018

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DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (3), p.816-825

2019

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Ligands stimulating antitumour immunity as the next G-quadruplex challenge

Molecular cancer, 2022-09, Vol.21 (1), p.1-180, Article 180

2022

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DNA Topoisomerase I differentially modulates R-loops across the human genome

Genome Biology, 2018-07, Vol.19 (1), p.100-100, Article 100

2018

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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Cell reports (Cambridge), 2019-09, Vol.28 (12), p.3167-3181.e6

2019

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In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

The Journal of pathology, 2012-07, Vol.227 (3), p.275-285

2012

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Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

PloS one, 2016-01, Vol.11 (1), p.e0147053

2016

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Characterization of novel antisense HIF-1α transcripts in human cancers

Cell cycle (Georgetown, Tex.), 2011-09, Vol.10 (18), p.3189-3197

2011

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Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

Cancer research (Chicago, Ill.), 2012-10, Vol.72 (20), p.5363-5373

2012

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TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

Cell reports (Cambridge), 2024-05, Vol.43 (5), p.114214, Article 114214

2024

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Comparison of Raltegravir and Elvitegravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants

Biochemistry (Easton), 2008-09, Vol.47 (36), p.9345-9354

2008

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Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Biochimica et biophysica acta. General subjects, 2017-05, Vol.1861 (5), p.1271-1280

2017

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Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

PloS one, 2014-12, Vol.9 (12), p.e114904

2014

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Type I DNA Topoisomerases

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2169-2192

2017

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Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7873-7877

2009

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Immunofluorescence microscopy of G-quadruplexes and R-loops

Methods in enzymology, 2024, Vol.695, p.103-118

2024

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Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?

British journal of cancer, 2024-08

2024

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Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

British journal of cancer, 2022-10, Vol.127 (7), p.1214-1225

2022

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Abstract 510: Topoisomerase IIβ silencing increases R loops at specific genomic loci associated with an increase of γH2AX and cell cycle progression delay in human cancer cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.510-510

2017

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RNA G‑Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9448-9461

2017

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Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

Nucleic acids research, 2013-12, Vol.41 (22), p.10110-10123

2013

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The day‐to‐day experiences of caring for children with Osteogenesis Imperfecta: A qualitative descriptive study

Journal of clinical nursing, 2020-08, Vol.29 (15-16), p.2999-3011

2020

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Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G‑Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12055-12067

2022

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Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity

Biochimica et biophysica acta, 2010-12, Vol.1806 (2), p.240-250

2010

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The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells

Molecular cancer therapeutics, 2014-01, Vol.13 (1), p.239-248

2014

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Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

Ligands stimulating antitumour immunity as the next G-quadruplex challenge

DNA Topoisomerase I differentially modulates R-loops across the human genome

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

Characterization of novel antisense HIF-1α transcripts in human cancers

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

Comparison of Raltegravir and Elvitegravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening

Type I DNA Topoisomerases

Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent

Immunofluorescence microscopy of G-quadruplexes and R-loops

Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?

Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway

Abstract 510: Topoisomerase IIβ silencing increases R loops at specific genomic loci associated with an increase of γH2AX and cell cycle progression delay in human cancer cells

RNA G‑Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

The day‐to‐day experiences of caring for children with Osteogenesis Imperfecta: A qualitative descriptive study

Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G‑Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity

The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells

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